Biological Role of Oxidative Stress in Inflammatory Processes

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 634

Special Issue Editor


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Guest Editor
Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Science, Rokietnicka 8, 60-806 Poznan, Poland
Interests: oxidative stress; redox balance; antioxidants; athersoclersois; inflammation
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Special Issue Information

Dear Colleagues,

This Special Issue seeks to present research results and conclusions that describe and explain the biological mechanisms related to oxidative stress and redox balance in inflammatory processes occurring in the body.

Oxidative stress and redox balance have been troubling the scientific community for years, as researchers have been seeking their causes and effects, as well as pharmacological solutions in the mechanisms associated with them. Due to developing research and analytical possibilities, more and more questions regarding, among others, the involvement in this process of triggering factors, transcription factors, receptors, antioxidants, and novel biomarkers may find a solution.

Therefore, we are seeking works that describe not only path mechanisms, but also biologically important compounds, whose impact on the body's redox balance significantly defines the inflammatory processes accompanying cardiovascular diseases, cancer, autoimmune, neurodegenerative diseases, and all disorders that lead to inflammation.

We hope that the set of hypotheses and conclusions collected in this Special Issue will have a significant clinical impact.

Dr. Magdalena Paulina Kasprzak
Guest Editor

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Keywords

  • oxidative stress
  • redox balance
  • antioxidants
  • NRF2
  • microbiota
  • bilirubin
  • Tlr4
  • inflammation

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Published Papers (1 paper)

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Review

12 pages, 1220 KiB  
Review
Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids
by Pedro-Antonio Regidor, Manuela Mayr, Fernando Gonzalez Santos, Beatriz Lazcoz Calvo, Rocio Gutierrez and Jose Miguel Rizo
Biomedicines 2025, 13(8), 1832; https://doi.org/10.3390/biomedicines13081832 - 26 Jul 2025
Viewed by 506
Abstract
Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms. Despite the high prevalence, pathogenesis of UF is not understood and involves cytokines, steroid hormones, and growth factors. [...] Read more.
Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms. Despite the high prevalence, pathogenesis of UF is not understood and involves cytokines, steroid hormones, and growth factors. Additionally, an increased deposition and remodelling of the extracellular matrix is characteristic for UF. Vitamin D seems to play a new role in UF. Interestingly, hypovitaminosis D correlates with a higher prevalence of myomas and the severity of the myomas. Administration of vitamin D in women with insufficiency (serum level <30 ng/mL) restored the vitamin D status and reduced the mild symptoms of myomas. In addition, inflammatory processes may play a role. In the past years, it has become clear that cessation of inflammation is an active process driven by a class of lipid mediator molecules called specialized pro-resolving mediators (SPM). Inadequate resolution of inflammation is related to several chronic inflammatory diseases and several studies have proven the crucial role of SPMs in improving these diseases. In this review, we will give an overview on processes involved in UF growth and will give an overview on the modern view regarding the concept of inflammation and the role of SPMs in resolution of inflammation, especially in chronic inflammatory diseases. Full article
(This article belongs to the Special Issue Biological Role of Oxidative Stress in Inflammatory Processes)
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