Search Results (403)

Wild edible fruit plants are integral to the cultural, nutritional, medicinal, and economic practices of Indigenous Isan communities in Roi Et Province, northeastern Thailand, a region characterized by plateau and lowland topography and a tropical monsoon climate. This study aimed to document the diversity, traditional uses, phenology, and conservation status of these species to inform sustainable management and conservation efforts. Field surveys and ethnobotanical interviews with 200 informants (100 men, 100 women; random ages) were conducted across 20 local communities to identify species diversity and usage patterns, while phenological observations and conservation assessments were performed to understand reproductive cycles and species vulnerability between January and December 2023. A total of 68 species from 32 families were recorded, with peak flowering in March–April and fruiting in May–June. Analyses of Species Use Value (0.19–0.48) and Relative Frequency of Citation (0.15–0.44) identified key species with significant roles in food security and traditional medicine. Uvaria rufa had the highest SUV (0.48) and RFC (0.44). Informant consensus on medicinal applications was strong for ailments such as gastrointestinal and lymphatic disorders. Economically important species were also identified, with some contributing notable income through local trade. Conservation proposed one species as Critically Endangered and several others as Vulnerable. The results highlight the need for integrated conservation strategies, including community-based initiatives and recognition of Other Effective area-based Conservation Measures (OECMs), to ensure the preservation of biodiversity, traditional knowledge, and local livelihoods. Full article

Malignant mediastinal tumors are a group representing some of the most demanding oncological challenges for early, multi-level, and successful management. The timely identification of any suspicious clinical symptomatology is urgent in achieving an accurate, staged histological diagnosis, in order to follow up with an equally detailed medical therapeutic plan (interventional or not) and determine the principal goals regarding efficient overall treatment in these patients. We report a case of a 24-year-old male patient with an incident-free prior medical history. An initial chest X-ray was performed after the patient reported short-term, consistent moderate chest pain symptomatology, early work fatigue, and shortness of breath. The following imaging procedures (chest CT, PET-CT) indicated the presence of an anterior mediastinal mass (meas. ~11 cm × 10 cm × 13 cm, SUV: 8.7), applying additional pressure upon both right heart chambers. The Alpha-Fetoprotein (aFP) blood levels had exceeded at least 50 times their normal range. Two consecutive diagnostic attempts with non-specific histological results, a negative-for-malignancy fine-needle aspiration biopsy (FNA-biopsy), and an additional tumor biopsy, performed via mini anterior (R) thoracotomy with “suspicious” cellular gatherings, were performed elsewhere. After admission to our department, an (R) Video-Assisted Thoracic Surgery (VATS) was performed, along with multiple tumor biopsies and moderate pleural effusion drainage. The tumor’s measurements had increased to DMax: 16 cm × 9 cm × 13 cm, with a severe degree of atelectasis of the Right Lower Lobe parenchyma (RLL) and a pressure-displacement effect upon the Superior Vena Cava (SVC) and the (R) heart sinus, based on data from the preoperative chest MRA. The histological report indicated elements of a combined, non-seminomatous germ-cell mediastinal tumor, posthuberal-type teratoma, and embryonal carcinoma. The imminent chemotherapeutic plan included a “BEP” (Bleomycin^®/Cisplatin^®/Etoposide^®) scheme, which needed to be modified to a “VIP” (Cisplatin^®/Etoposide^®/Ifosfamide^®) scheme, due to an acute pulmonary embolism incident. While the aFP blood levels declined, even reaching normal measurements, the tumor’s size continued to increase significantly (DMax: 28 cm × 25 cm × 13 cm), with severe localized pressure effects, rapid weight loss, and a progressively worsening clinical status. Thus, an emergency surgical intervention took place via median sternotomy, extended with a complementary “T-Shaped” mini anterior (R) thoracotomy. A large, approx. 4 Kg mediastinal tumor was extracted, with additional RML and RUL “en-bloc” segmentectomy and partial mediastinal pleura decortication. The following histological results, apart from verifying the already-known posthuberal-type teratoma, indicated additional scattered small lesions of combined high-grade rabdomyosarcoma, chondrosarcoma, and osteosarcoma, as well as numerous high-grade glioblastoma cellular gatherings. No visible findings of the previously discovered non-seminomatous germ-cell and embryonal carcinoma elements were found. The patient’s postoperative status progressively improved, allowing therapeutic management to continue with six “TIP” (Cisplatin^®/Paclitaxel^®/Ifosfamide^®) sessions, currently under his regular “follow-up” from the oncological team. This report underlines the importance of early, accurate histological identification, combined with any necessary surgical intervention, diagnostic or therapeutic, as well as the appliance of any subsequent multimodality management plan. The diversity of mediastinal tumors, especially for young patients, leaves no place for complacency. Such rare examples may manifest, with equivalent, unpredictable evolution, obliging clinical physicians to stay constantly alert and not take anything for granted. Full article

Background: Hypometabolism of the thalamus has been reported in epilepsy patients. This study aimed to investigate the prognostic value of thalamic metabolic activity in children with epilepsy. Methods: A total of 200 children with epilepsy and 237 children without epilepsy (sex- and age-matched control group) underwent 18F-FDG PET/CT in this study. Localization of the interictal hypometabolic epileptic focus was performed visually. Bilateral thalamic metabolic activity was evaluated qualitatively (thalamic FDG uptake in relation to the cerebral cortex) and semi-quantitatively (SUV max, normalized SUV (ratio to ipsilateral cerebellum), and absolute asymmetric index (AAI). Results: A total of 133 patients (66.5%) with epilepsy showed cerebral cortical hypometabolism in the interictal 18F-FDG PET study; there were 76 patients on the right side, 55 patients on the left side, and two patients on both sides. Of these 133 patients, 45 also had visually observed asymmetric hypometabolism in the thalamus. Semi-quantitatively, asymmetry was more prominent in epileptic patients. AAI was a more sensitive variable than other variables. Average AAIs were 3.89% and 7.36% in the control and epilepsy patients, respectively. Metabolic activity in the thalami was significantly reduced in epileptic patients compared to the control group. Associated hypometabolism of the ipsilateral thalamus was observed in 66.5% of epileptic patients with a focal cortical defect semi-quantitatively. Overall, 61 out of 200 patients showed thalamus hypometabolism. Some 51 out of 61 patients (83.6%) with thalamus hypometabolism showed refractory disease; however, the refractory disease was noted in 90 out of 139 (64.7%) patients without thalamus hypometabolism. Brain surgery was performed in 86 epileptic patients (43%). Some 35 out of 86 patients had thalamus hypometabolism. Recurrence of epilepsy was observed more in patients with thalamus hypometabolism (48% vs. 25%), with p ≤ 0.01. Conclusion: This study suggests that patients with thalamus metabolic abnormalities may be more medically resistant to therapy and less responsive to surgical treatments. Therefore, the thalamus metabolic abnormality could be used as a prognostic sign in pediatric epilepsy. Recent studies have also suggested that incorporating thalamic metabolic data into clinical workflows may improve the stratification of treatment-resistant epilepsy in children. Full article

This study presents a data-driven, multi-objective optimization framework for user-centric product form design, integrating affective response modeling with coupled constraint satisfaction. Initially, morphological analysis and aesthetic evaluation are employed to extract critical design elements, while cluster analysis segments users based on preference data. Dominance-based rough set theory is then applied to derive group-specific affective patterns, which are subsequently modeled using Genetic Algorithm-optimized Backpropagation Neural Networks (GA-BPNN). The framework leverages Non-dominated Sorting Genetic Algorithm II (NSGA-II) to generate Pareto-optimal solutions, balancing aesthetic preferences and engineering constraints across user groups. A case study on SUV form design validates the proposed methodology, demonstrating its efficacy in delivering optimal, user-group-targeted design solutions while accommodating individual variability and constraint interdependencies. The results highlight the framework’s potential as a generalizable approach for emotion-aware, constraint-compliant product design. Full article

This study investigates the use of a custom-built 10 GHz continuous wave micro-Doppler radar system to analyze external vibrations of idling vehicles under various conditions. Scenarios included different gear engagements with one occupant and parked gear with up to four occupants. Motivated by security concerns, such as the threat posed by idling vehicles with multiple occupants, the research explores how micro-Doppler signatures can indicate vehicle readiness to move. Experiments focused on a mid-size SUV, with similar trends seen in other vehicles. Radar data were compared to in situ accelerometer measurements, confirming that the radar system can detect subtle frequency changes, especially during gear shifts. The system’s sensitivity enables it to distinguish variations tied to gear state and passenger load. Extracted features like frequency and magnitude show strong potential for use in machine learning models, offering a non-invasive, remote sensing method for reliably identifying vehicle operational states and occupancy levels in security or monitoring contexts. Spectrogram and PSD analyses reveal consistent tonal vibrations around 30 Hz, tied to engine activity, with harmonics at 60 Hz and 90 Hz. Gear shifts produce impulse signatures primarily below 20 Hz, and transient data show distinct peaks at 50, 80, and 100 Hz. Key features at 23 Hz and 45 Hz effectively indicate engine and gear states. Radar and accelerometer data align well, supporting the potential for remote sensing and machine learning-based classification. Full article

Background/Objectives: The SENTIREC-endo study identified a safe sentinel lymph node mapping algorithm combined with PET-positive node dissection, matching radical pelvic and paraaortic lymphadenectomy in high-risk endometrial cancer. The present study evaluated the diagnostic accuracy of FDG-PET/CT for lymph node metastases in the same population based on location, size, and Standardised Uptake Value (SUV), in addition to assessing interrater agreement across three Danish centres. Methods: This prospective multicentre study included women with high-risk endometrial cancer from the Danish SENTIREC study database (2017–2023). All patients underwent preoperative FDG-PET/CT. Diagnostic accuracy was evaluated against a pathology-confirmed reference standard. Interrater agreement was evaluated between trained specialists in Nuclear Medicine. Results: Among 227 patients, 52 patients (23%) had lymph node metastases. FDG-PET/CT identified lymph node metastases with 56% sensitivity (95% CI: 42–68) and 91% specificity (95% CI: 86–94). Positive and negative predictive values were 64% and 87%, respectively. Specificity for paraaortic nodes was high (97%), though sensitivity remained limited (56%). Lymph node size and SUVmax had moderate diagnostic value (AUC-ROC ~0.7). Interrater proportion of agreement was 95% and Cohen’s Kappa κ = 0.84 (95% CI: 0.73–0.94), the latter of which was ‘almost perfect’. Conclusions: FDG-PET/CT had limited sensitivity in lymph node staging in high-risk EC, and the diagnostic accuracy of FDG-PET/CT remains complementary to the sentinel node procedure. Due to its high specificity and strong interrater reliability, FDG-PET/CT is recommended for clinical implementation in combination with the sensitive sentinel node biopsy for the targeted dissection of PET-positive lymph nodes, particularly in paraaortic regions. Full article

With the increasing environmental pollution and resource consumption caused by automobiles, a lightweight design of automobiles is the best solution at present. In this paper, the load-bearing frame of pure electric SUVs is taken as the research object. The finite element analysis method is used to analyze the strength, stiffness and modal performance of the load-bearing frame, and the material selection of the frame is optimized according to the analysis results to achieve a lightweight design. First, a three-dimensional model of the pure electric SUV frame is established using SolidWorks software 2019 and then imported into ANSYS 2024 R1 Workbench for meshing and material property definition. Then, through finite element static analysis, the various force conditions of the frame under three typical working conditions of full-load bending, full-load braking and full-load turning are simulated; the stress distribution and deformation of the frame under different working conditions are confirmed; and the strength and stiffness performance of the frame are evaluated. After the above analysis, a modal analysis of the frame is carried out, and the natural frequency and vibration mode of the frame are finally obtained. According to the analysis results, the material replacement method is selected to optimize the lightweight design of the frame. The results show that the weight of the frame is significantly reduced after material optimization, while still meeting the strength, stiffness and modal performance requirements. This article provides a certain reference value for the lightweight design of pure electric SUV frames in the future. Full article

The Bignoniaceae family encompasses numerous species of ecological, medicinal, and cultural significance, yet its ethnobotanical value remains underexplored in many regions of Thailand. This study investigates the diversity, phenology, cultural relevance, and traditional uses of Bignoniaceae species in Maha Sarakham Province, Northeastern Thailand. Through semi-structured interviews with 260 local informants across 13 districts—alongside field observations and herbarium voucher collections—we documented 27 species across 21 genera. These integrated methods enabled the identification of key culturally significant species and provided insights into their traditional uses. Phenological data revealed clear seasonal patterns in flowering and fruiting, aligned with the regional climatic cycle. Quantitative ethnobotanical indices—including Species Use Value (SUV), Genera Use Value (GUV), Relative Frequency of Citation (RFC), Cultural Importance Index (CI), and Cultural Food Significance Index (CFSI)—were employed to evaluate species significance. Results indicate that species such as Dolichandrone serrulata, D. spathacea, and Oroxylum indicum hold high cultural and practical value, particularly in traditional medicine, spiritual practices, and local landscaping. These findings underscore the critical role of Bignoniaceae in sustaining biocultural diversity and emphasize the urgency of preserving traditional botanical knowledge amid environmental and socio-economic change. Moreover, the insights contribute to broader efforts in cultural heritage preservation and biodiversity conservation across tropical and subtropical regions. Full article

The transition to passenger car electrification is a crucial step in China’s strategic efforts to achieve carbon peak and carbon neutrality. However, previous research has not considered the variances in vehicle models. Hence, this study aims to fill this gap by comparing the carbon emission reduction and economic feasibility of battery electric vehicles (BEVs) in the Chinese market, taking into account different powertrains, vehicle segments, classes, and driving ranges. Next, the study identifies the most cost-effective BEV within each market segment, employing life-cycle assessment and life cycle cost analysis methods. Moreover, at different levels of technological development, we construct three low-carbon measures, including electricity decarbonization (ED), energy efficiency improvement (EEI), and vehicle lightweight (LW), to quantify the emission mitigation potentials from different carbon reduction pathways. The findings indicate that BEVs achieve an average carbon reduction of about 31.85% compared to internal combustion engine vehicles (ICEVs), demonstrating a significant advantage in carbon reduction. However, BEVs are not economically competitive. The total life cycle cost of BEVs is 1.04–1.68 times higher than that of ICEVs, with infrastructure costs accounting for 18.8–57.8% of the vehicle’ s life cycle costs. In terms of cost-effectiveness, different models yield different results, with sedans generally outperforming sport utility vehicles (SUVs). Among sedans, both A-class and B-class sedans have already reached a point of cost-effectiveness, with the BEV400 emerging as the optimal choice. In low-carbon emission reduction scenarios, BEVs could achieve carbon reduction potentials of up to 45.3%, 14.9%, and 9.0% in the ED, EEI, and LW scenarios, respectively. Thus, electricity decarbonization exhibits the highest potential for mitigating carbon emissions, followed by energy efficiency improvement and vehicle lightweight. There are obvious differences in the stages of impact among different measures. The ED measure primarily impacts the waste treatment process (WTP) stage, followed by the vehicle cycle, while the EEI measure only affects the WTP stage. The LW measure has a complex impact on emission reductions, as the carbon reductions achieved in the WTP stage are partially offset by the increased carbon emissions in the vehicle cycle. Full article

Background/Objectives: Diagnosis of Persistent Spinal Pain Syndrome Type 2 (PSPS-T2) currently lacks objective biomarkers. Therefore, this retrospective study aimed to investigate differences in glucose metabolism in the axial musculoskeletal system in PSPS-T2 patients by means of [¹⁸F]FDG PET-CT imaging. Methods: Nine PSPS-T2 patients (five females, four males; mean age of 53 ± 4.82 years) and nine age- and gender-matched healthy controls (five females, four males; mean age of 53 ± 3.91 years) were included. For each participant, 24 regions of interest (ROIs) were manually drawn, including areas of the vertebral endplates, the intervertebral discs, and the psoas muscles. For each ROI, the mean standardized uptake values (SUVs) were assessed. Group differences were evaluated using repeated measures ANOVA with Bonferroni-adjusted post-hoc pairwise comparisons. Additionally, Pearson correlation analyses examined associations between SUV_mean values and the Numerical Rating Scale (NRS) pain scores. Results: Results demonstrated significantly higher SUV_mean values in healthy controls compared to PSPS-T2 patients, particularly at the superior endplates of L4 and S1, the intervertebral discs at L4-L5 and L5-S1, and the posterior endplates of L4 and L5. Although PSPS-T2 patients exhibited higher SUV_mean values than controls in the psoas muscle, these differences were not statistically significant. Additionally, no significant correlations were found between SUV_mean values and NRS pain scores, suggesting that metabolic activity alone does not directly reflect pain severity. Conclusions: Despite the limited sample size of this pilot study, the metabolic fingerprint of the axial musculoskeletal system was shown to be distinctly different in PSPS-T2 patients compared to healthy controls. This could lead to an improved understanding of PSPS-T2 pathophysiology and might open new doors for better diagnosis and treatment strategies. Full article

The transportation sector in South Asia largely depends on internal combustion engine (ICE) vehicles, which are responsible for a large share of greenhouse gas (GHG) emissions, air pollution, and the increase in fuel prices. Although hybrid electric vehicles (HEVs), plug-in hybrid electric vehicles (PHEVs), and fully electric vehicles (EVs) constitute promising alternatives, the rate of their implementation is low due to factors such as the high initial investment, the absence of the required infrastructure, and the reliance on fossil fuel-based electricity. This study is the first of its kind to examine Bangladesh’s drivetrain options in a comprehensive way, with in-depth real-world emission testing and economic analysis as the main tools of investigation into the environmental and economic feasibility of different technologies used in the vehicles available in Bangladesh, including lifecycle costs and infrastructure constraints. The study findings have shown that hybrid and plug-in hybrid vehicles are the best options, since they have moderate emissions and cost efficiency, respectively. Fully electric vehicles, however, face two main challenges: the overall lack of charging infrastructure and the overall high purchase prices. Among the evaluated technologies, PHEVs exhibited the lowest environmental and economic burden. The Toyota Prius PHEV emitted 98% less NOx compared to the diesel-powered Pajero Sport and maintained the lowest per-kilometer cost at BDT 6.39. In contrast, diesel SUVs emitted 178 ppm NOx and cost 22.62 BDT/km, reinforcing the transitional advantage of plug-in hybrid technology in Bangladesh’s context. Full article

The integration of intelligent voice-control systems represents a critical pathway for enhancing driver comfort and reducing cognitive distraction in modern vehicles. Currently, voice assistants capable of accessing real-time vehicular data (e.g., engine parameters) or controlling actuators (e.g., door locks) remain exclusive to premium brands. While aftermarket solutions like Amazon’s Echo Auto provide multimedia functionality, they lack access to critical vehicle systems. To address this gap, we develop a novel architecture leveraging the OBD-II port to enable voice-controlled telematics and actuation in mass-production vehicles. Our system interfaces with a Toyota Hilux (2020) and Mazda CX-3 SUV (2021), utilizing an MCP2515 CAN controller for engine control unit (ECU) communication, an Arduino Nano for data processing, and an ESP01 Wi-Fi module for cloud transmission. The Blynk IoT platform orchestrates data flow and provides user interfaces, while a Voiceflow-programmed Alexa skill enables natural language commands (e.g., “unlock doors”) via Alexa Auto. Experimental validation confirms the successful real-time monitoring of engine variables (coolant temperature, air–fuel ratio, ignition timing) and secure door-lock control. This work demonstrates that high-end vehicle capabilities—previously restricted to luxury segments—can be effectively implemented in series-production automobiles through standardized OBD-II protocols and IoT integration, establishing a scalable framework for next-generation in-vehicle assistants. Full article

Psoriasis involves complex epigenetic alterations, but detailed studies on histone methyltransferases and their role in disease progression are limited. We conducted a comprehensive analysis of nearly 300 transcriptomes, focusing mainly on differential expression of protein isoform-coding transcripts within the SET domain family of histone methyltransferases. Consistent with previous findings, EZH2 transcripts showed increased expression in lesional skin, indicating altered H3K27 methylation that may enhance gene silencing, promoting keratinocyte proliferation and inflammatory responses. In the SET2 family, ASH1L exhibited reversed expression patterns between non-lesional and lesional skin, while NSD1 and NSD2 were upregulated, and SETD2 downregulated in lesions, suggesting disrupted H3K36 methylation that may affect immune responses and keratinocyte proliferation. Among H3K9 methyltransferases, SUV39 members, SUV39H2 was upregulated in lesions, whereas EHMT1 transcripts increased in non-lesional skin, and SETDB2 decreased in lesions. Additionally, PRDM family members such as PRDM2, MECOM (PRDM3), PRDM6, and PRDM8 showed altered expression in lesional skin. The H4K20 methylating SUV4-20 subfamily member, a SUV420H1 transcript, and SETD8 belonging to the other SET domain-containing family of methyltransferases were significantly increased in non-lesional skin and in lesions, respectively. Overall, aberrant expression and isoform variability of histone methyltransferases likely contribute to psoriasis pathogenesis by dysregulating proliferation, differentiation, and immune responses. Full article

Background/Objectives: Pulmonary lymphangitic carcinomatosis (PLC) is a rare, aggressive manifestation of metastatic cancer characterized by lymphatic infiltration of the lungs, typically indicating advanced disease and poor prognosis. Methods: This comprehensive narrative review evaluates the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging in assessing PLC. Results: Current evidence demonstrates that [18F]FDG PET/CT achieves high diagnostic accuracy, with sensitivity and specificity ranging from 86 to 97% and 84 to 100%, respectively, particularly when employing semiquantitative metrics such as peritumoral standardized uptake value (SUVmax) thresholds (e.g., ≥2.1). PET/CT surpasses high-resolution computed tomography (HRCT) in distinguishing PLC from mimics like pulmonary sarcoidosis by identifying distinct metabolic patterns: bronchovascular hypermetabolism in PLC versus subpleural nodular uptake in sarcoidosis. Prognostically, metabolic tumor burden (e.g., SUVmax × involved lobes) and novel cPLC classifications (localized to the ipsilateral or contralateral lung) independently predict progression-free survival. However, challenges persist, including non-specific tracer uptake in inflammatory conditions and variability in SUV measurements due to technical factors. Emerging digital PET/CT systems, with enhanced spatial resolution, may improve the detection of focal PLC and reduce false negatives. While [18F]FDG PET/CT is invaluable for whole-body staging, therapeutic monitoring and biopsy guidance, the standardization of protocols and multicenter validation of prognostic models are critical for clinical integration. Future research should explore novel tracers (e.g., PSMA for prostate cancer-related PLC) and machine learning approaches to refine diagnostic and prognostic accuracy. Conclusions: This review underscores the role and the transformative potential of [18F]FDG PET/CT in PLC management while advocating for rigorous standardization to maximize its clinical utility. Full article

Desert highways, with open terrain and minimal wind barriers, expose high-speed vehicles to significant stability risks from combined crosswinds and sand accumulation. This study uses numerical simulation to assess the effects of varying wind direction angles and sand thicknesses on vehicle stability across different models. Five dynamic indicators—lateral displacement, yaw angle, aerodynamic sideslip angle, lateral acceleration, and roll angle—are analyzed. The results show that a 120° wind angle causes the most pronounced parameter changes, while stability is lowest at 150°, where critical thresholds are reached within 0.75 s and danger thresholds by 2.25 s. Rapid wind speed variations further degrade stability. Compared to small SUVs, mid-size SUVs perform worse under identical conditions. A comprehensive stability evaluation function is proposed to quantify the combined impact of wind angle and surface friction, providing a new approach for safety assessment on sand-covered desert roads. Full article