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Search Results (4,924)

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21 pages, 2047 KiB  
Article
Sustainable Management of Fruit By-Products Through Design Thinking: Development of an Innovative Food Product
by Sylwia Sady, Alfred Błaszczyk, Bogdan Pachołek, Anna Muzykiewicz-Szymańska, Anna Nowak, Justyna Syguła-Cholewińska, Tomasz Sawoszczuk, Stanisław Popek, Małgorzata Krzywonos, Agnieszka Piekara and Dominika Jakubowska
Sustainability 2025, 17(15), 7164; https://doi.org/10.3390/su17157164 (registering DOI) - 7 Aug 2025
Abstract
Sustainable development and the circular economy have become key challenges in the modern food sector, calling for innovative solutions that reduce waste and promote the efficient use of resources. The aim of this study was to develop a functional food product by utilizing [...] Read more.
Sustainable development and the circular economy have become key challenges in the modern food sector, calling for innovative solutions that reduce waste and promote the efficient use of resources. The aim of this study was to develop a functional food product by utilizing by-products from chokeberry processing, thereby contributing to circularity in food systems. The integration of design thinking with fermentation of chokeberry pomace is presented in this study as an approach to developing value-added food ingredients. Qualitative consumer research (focus group interviews, n = 36) identified preferences and expectations regarding functional foods containing by-products. Conducted by an interdisciplinary team, the project followed five stages, involving both qualitative and quantitative research. Liquid surface fermentation was performed using Aspergillus niger, selected for its proven ability to enhance the antioxidant capacity and polyphenol content of plant matrices. The optimal process was 2-day fermentation under controlled pH conditions with glucose supplementation, which significantly enhanced the quality and nutritional value of the final product. Antioxidant activity (ABTS, FRAP, CUPRAC assays), total polyphenols, anthocyanins, and proanthocyanidins were determined, showing significant increases compared to non-fermented controls. The outcome was the development of a dried, fermented chokeberry pomace product that meets consumer expectations and fulfils sustainability goals through waste reduction and innovative reuse of fruit processing by-products. Full article
(This article belongs to the Special Issue Innovative Technologies in Food Engineering Towards Sustainability)
32 pages, 5466 KiB  
Article
Comprehensive Energy and Economic Analysis of Selected Variants of a Large-Scale Photovoltaic Power Plant in a Temperate Climate
by Dennis Thom, Artur Bugała, Dorota Bugała and Wojciech Czekała
Energies 2025, 18(15), 4198; https://doi.org/10.3390/en18154198 - 7 Aug 2025
Abstract
In recent years, solar energy has emerged as one of the most advanced renewable energy sources, with its production capacity steadily growing. To maximize output and efficiency, choosing the right configuration for a specific location for these installations is crucial. This study uniquely [...] Read more.
In recent years, solar energy has emerged as one of the most advanced renewable energy sources, with its production capacity steadily growing. To maximize output and efficiency, choosing the right configuration for a specific location for these installations is crucial. This study uniquely integrates detailed multi-variant fixed-tilt PV system simulations with comprehensive economic evaluation under temperate climate conditions, addressing site-specific spatial constraints and grid integration considerations that have rarely been combined in previous works. In this paper, an energy and economic efficiency analysis for a photovoltaic power plant, located in central Poland, designed in eight variants (10°, 15°, 20°, 25°, 30° PV module inclination angle for a south orientation and 10°, 20°, 30° for an east–west orientation) for a limited building area of approximately 300,000 m2 was conducted. In PVSyst computer simulations, PVGIS-SARAH2 solar radiation data were used together with the most common data for describing the Polish local solar climate, called Typical Meteorological Year data (TMY). The most energy-efficient variants were found to be 20° S and 30° S, configurations with the highest surface production coefficient (249.49 and 272.68 kWh/m2) and unit production efficiency values (1123 and 1132 kWh/kW, respectively). These findings highlight potential efficiency gains of up to approximately 9% in surface production coefficient and financial returns exceeding 450% ROI, demonstrating significant economic benefits. In economic terms, the 15° S variant achieved the highest values of financial parameters, such as the return on investment (ROI) (453.2%), the value of the average annual share of profits in total revenues (56.93%), the shortest expected payback period (8.7 years), the value of the levelized cost of energy production (LCOE) (0.1 EUR/kWh), and one of the lowest costs of building 1 MWp of a photovoltaic farm (664,272.7 EUR/MWp). Among the tested variants of photovoltaic farms with an east–west geographical orientation, the most advantageous choice is the 10° EW arrangement. The results provide valuable insights for policymakers and investors aiming to optimize photovoltaic deployment in temperate climates, supporting the broader transition to renewable energy and alignment with national energy policy goals. Full article
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24 pages, 5480 KiB  
Article
Liposomal Co-Delivery of Acteoside, CBD, and Naringenin: A Synergistic Strategy Against Gliomas
by Jagoda Szkudlarek, Ludwika Piwowarczyk, Violetta Krajka-Kuźniak, Aleksandra Majchrzak-Celińska, Szymon Tomczak, Mikołaj Baranowski, Rafał Pietrzyk, Aneta Woźniak-Braszak and Anna Jelińska
Pharmaceutics 2025, 17(8), 1026; https://doi.org/10.3390/pharmaceutics17081026 - 7 Aug 2025
Abstract
Background/Objectives: Adult-type diffuse gliomas, including astrocytoma and glioblastoma multiforme (GBM), are brain tumors with a very poor prognosis. While current treatment options for glioma patients are not providing satisfactory outcomes, research indicates that natural compounds could serve as alternative treatments. However, their [...] Read more.
Background/Objectives: Adult-type diffuse gliomas, including astrocytoma and glioblastoma multiforme (GBM), are brain tumors with a very poor prognosis. While current treatment options for glioma patients are not providing satisfactory outcomes, research indicates that natural compounds could serve as alternative treatments. However, their low bioavailability requires nanotechnology solutions, such as liposomes. Methods: In this study, we propose the co-encapsulation of acteoside (ACT) with other natural compounds, cannabidiol (CBD) or naringenin (NG), in a cationic liposomal nanoformulation consisting of DOTAP and POPC lipids, which were prepared using the dry lipid film method. The liposomes were characterized by their physicochemical properties, including particle size, zeta potential, and polydispersity index (PDI), with additional analyses performed using 1H Nuclear Magnetic Resonance (NMR). Furthermore, biological experiments were performed with U-87 MG astrocytoma and U-138 MG GBM cell lines and non-cancerous MRC-5 lung fibroblasts using the MTT assay and evaluating the expression of Bax and Bcl-xL to evaluate their potential as anticancer agents. Conclusions: The IC50 values for the nanoformulations in U-138 MG cells at 48 h were 6 µM for ACT + CBD and 5 µM for ACT + NG. ACT and CBD or NG demonstrated a potential synergistic effect against GBM in a liposomal formulation. Notably, treatment with ACT + CBD (5 µM) and ACT + NG (5 µM) liposomal formulations significantly upregulated Bax protein level in U-138 cells at both 24 and 48 h. In parallel, ACT + CBD (5 µM) also modulated Bcl-xL protein level in both U-138 MG and U-87 MG cell lines at the same time points. The obtained nanoformulations were homogeneous and stable for 21 days, evidenced by a narrow particle size distribution, a low polydispersity index (PDI) < 0.3, and a positive zeta potential. Full article
(This article belongs to the Special Issue PLGA Micro/Nanoparticles in Drug Delivery)
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24 pages, 2085 KiB  
Article
Transcriptomic Characterization of Candidate Genes for Fusarium Resistance in Maize (Zea mays L.)
by Aleksandra Sobiech, Agnieszka Tomkowiak, Tomasz Jamruszka, Tomasz Kosiada, Julia Spychała, Maciej Lenort and Jan Bocianowski
Pathogens 2025, 14(8), 779; https://doi.org/10.3390/pathogens14080779 - 6 Aug 2025
Abstract
Fusarium diseases are among the most dangerous fungal diseases of plants. To date, there are no plant protectants that completely prevent fusariosis. Current breeding trends are therefore focused on increasing genetic resistance. While global modern maize breeding relies on various molecular genetics techniques, [...] Read more.
Fusarium diseases are among the most dangerous fungal diseases of plants. To date, there are no plant protectants that completely prevent fusariosis. Current breeding trends are therefore focused on increasing genetic resistance. While global modern maize breeding relies on various molecular genetics techniques, they are useless without a precise characterization of genomic regions that determine plant physiological responses to fungi. The aim of this study was thus to characterize the expression of candidate genes that were previously reported by our team as harboring markers linked to fusarium resistance in maize. The plant material included one susceptible and four resistant varieties. Biotic stress was induced in adult plants by inoculation with fungal spores under controlled conditions. qRT-PCR was performed. The analysis focused on four genes that encode for GDSL esterase/lipase (LOC100273960), putrescine hydroxycinnamyltransferase (LOC103649226), peroxidase 72 (LOC100282124), and uncharacterized protein (LOC100501166). Their expression showed differences between analyzed time points and varieties, peaking at 6 hpi. The resistant varieties consistently showed higher levels of expression compared to the susceptible variety, indicating their stronger defense responses. Moreover, to better understand the function of these genes, their expression in various organs and tissues was also evaluated using publicly available transcriptomic data. Our results are consistent with literature reports that clearly indicate the involvement of these genes in the resistance response to fusarium. Thus, they further emphasize the high usefulness of the previously selected markers in breeding programs to select fusarium-resistant maize genotypes. Full article
(This article belongs to the Special Issue Current Research on Fusarium: 2nd Edition)
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22 pages, 2670 KiB  
Review
Sodium Chloride in Food
by Sylwia Chudy, Agnieszka Makowska and Ryszard Kowalski
Foods 2025, 14(15), 2741; https://doi.org/10.3390/foods14152741 - 6 Aug 2025
Abstract
Sodium chloride is a chemical compound that has been encountered by people for thousands of years, and plays a significant role in their lives. The aim of this article is to provide a comprehensive review of table salt from the perspective of health, [...] Read more.
Sodium chloride is a chemical compound that has been encountered by people for thousands of years, and plays a significant role in their lives. The aim of this article is to provide a comprehensive review of table salt from the perspective of health, food technology, and cultural heritage. The article discusses salt extraction and production, its composition and consumption, and its effects on the human body. The authors draw attention to new trends, such as the use of micronized salt, microencapsulated salt, and salt with colors and shapes that differ from those of typical table salt. Scientific studies on the presence of undesirable substances and the use of salt additives were reviewed. The role of salt in dairy, meat, and bakery technology was illustrated. Gaps in research on salt were highlighted. In the last part, all types of salt with geographical indications are shown. The paper suggests that producers with a long tradition in the salt sector should apply for the European geographical indications to enhance their national and cultural heritage and promote their region. The review highlights the need for further research on all aspects discussed. Full article
(This article belongs to the Section Food Quality and Safety)
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22 pages, 6319 KiB  
Article
Third Demographic Transition, Religion, Migrations and Economy: A Bibliometric Analysis of the Semantic Context
by Jarosław Kozak, Jakub Isański, Błażej Dyczewski, Adelaide di Maggio and Malika Ouacha
Religions 2025, 16(8), 1015; https://doi.org/10.3390/rel16081015 - 6 Aug 2025
Abstract
This article aims to analyze the role of migration in the process of the third demographic transition (TDT) in the context of key mediating determinants, such as migrants’ religiosity and economic conditions in the countries of origin and settlement. TDT refers to population [...] Read more.
This article aims to analyze the role of migration in the process of the third demographic transition (TDT) in the context of key mediating determinants, such as migrants’ religiosity and economic conditions in the countries of origin and settlement. TDT refers to population changes resulting from migration as a demographic compensatory mechanism in countries with a low total fertility rate (TFR). The study is based on a network analysis of keywords in the scientific literature using the Scopus database and VOSviewer. The results point to three main research approaches to TDT—investigating quantitative population changes, the sociodemographic consequences of migration, and its effect on urbanization—and to the fact that economic and axionormative determinants are under-researched. This article contributes to TDT theory, pointing to the need for that theory to include cultural, economic, and axiological factors as key determinants influencing the permanence of TDT. Full article
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13 pages, 223 KiB  
Article
Preliminary Research on the Efficacy of Selected Herbicides Approved for Use in Sustainable Agriculture Using Spring Cereals as an Example
by Piotr Szulc, Justyna Bauza-Kaszewska, Marek Selwet and Katarzyna Ambroży-Deręgowska
Sustainability 2025, 17(15), 7090; https://doi.org/10.3390/su17157090 - 5 Aug 2025
Abstract
The objective of this study was to evaluate the efficacy of selected herbicides permitted for use in sustainable agriculture, specifically targeting spring rye and spring barley in a no-till farming system. The application of chemical herbicide protection in the cultivation of spring rye [...] Read more.
The objective of this study was to evaluate the efficacy of selected herbicides permitted for use in sustainable agriculture, specifically targeting spring rye and spring barley in a no-till farming system. The application of chemical herbicide protection in the cultivation of spring rye and barley significantly increased the yield and improved the quality parameters of the harvested grain, with the most pronounced effect observed in spring barley. The effectiveness of the herbicide treatment in reducing the number of weeds was 99.4% for spring rye and 82.39% for spring barley. The study demonstrated that the application of chemical herbicide protection had a positive impact on the quality parameters of spring barley grain. Both the thousand-grain weight and protein content were significantly higher in the grain collected from protected plots compared to the control plots. By utilizing herbicides permitted for use in integrated production (IP) in a sustainable manner, we protect the environment while minimizing the impact on crop yields and maintaining the quality of the harvested produce. Full article
12 pages, 1125 KiB  
Article
Algorithmic Trading System with Adaptive State Model of a Binary-Temporal Representation
by Michal Dominik Stasiak
Risks 2025, 13(8), 148; https://doi.org/10.3390/risks13080148 - 4 Aug 2025
Viewed by 80
Abstract
In this paper a new state model is introduced, an adaptative state model in a binary temporal representation (ASMBRT) as well as its application in constructing an algorithmic trading system. The presented model uses the binary temporal representation, which allows for a precise [...] Read more.
In this paper a new state model is introduced, an adaptative state model in a binary temporal representation (ASMBRT) as well as its application in constructing an algorithmic trading system. The presented model uses the binary temporal representation, which allows for a precise analysis of exchange rates without losing any informative value of the data. The basis of the model is the trajectory analysis for the ensuing changes in price quotations and dependencies between the duration of each change. The main advantage of the model is to eliminate the threshold analysis, used in existing state models. This solution allows for a more accurate identification of investor behavior patterns, which translates into a reduction of investment risk. In order to verify obtained results in practice, the paper presents a concept of creating an algorithmic trading system and an analysis of its financial effectiveness for the exchange rate most popular among investors, namely EUR/USD. Full article
(This article belongs to the Special Issue Advances in Risk Models and Actuarial Science)
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16 pages, 1167 KiB  
Article
Upcycling of Sunflower and Sesame Press Cakes as Functional Ingredients in Cookies
by Iwona Jasińska-Kuligowska, Maciej Kuligowski, Mateusz Wyszyński and Marcin Kidoń
Sustainability 2025, 17(15), 7056; https://doi.org/10.3390/su17157056 - 4 Aug 2025
Viewed by 177
Abstract
The aim of the study was to evaluate the use of sunflower and sesame oilseed press cakes, which are by-products of oil extraction, as functional ingredients in cookie production. The quality characteristics of these by-products were assessed, including water activity, pH, total phenolic [...] Read more.
The aim of the study was to evaluate the use of sunflower and sesame oilseed press cakes, which are by-products of oil extraction, as functional ingredients in cookie production. The quality characteristics of these by-products were assessed, including water activity, pH, total phenolic content, and antioxidant activity, and HPLC analysis of the phenolic compounds was performed. Subsequently, cookies were prepared by replacing wheat flour with 30% or 50% press cake. The addition of sunflower press cake significantly increased the total phenolic content (up to 8.6 mg GAE/g dm) and antioxidant activity (up to 75.9%) in the cookies, whereas adding sesame press cake showed a less pronounced effect, reaching 0.91 g GAE/g dm and 8.9% for total phenolic content and antioxidant activity, respectively. HPLC analysis indicated that chlorogenic acid and its derivatives dominated in sunflower-enriched cookies, while sesame samples contained lignans such as sesamol and sesamin. Our study shows that 50% substitution improves the health-promoting properties of cookies and does not differ significantly from the 30% level in consumer sensory evaluations. These findings support the use of sunflower and sesame press cakes as valuable ingredients in food applications. This represents an important step toward developing healthier and more nutritious food products while supporting the principles of the circular economy through the upcycling of valuable raw materials. Full article
(This article belongs to the Special Issue By-Products of the Agri-Food Industry: Use for Food Fortification)
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22 pages, 3994 KiB  
Article
Analysis of Foaming Properties, Foam Stability, and Basic Physicochemical and Application Parameters of Bio-Based Car Shampoos
by Bartosz Woźniak, Agata Wawrzyńczak and Izabela Nowak
Coatings 2025, 15(8), 907; https://doi.org/10.3390/coatings15080907 - 2 Aug 2025
Viewed by 314
Abstract
Environmental protection has become one of the key challenges of our time. This has led to an increase in pro-environmental activities in the field of cosmetics and household chemicals, where manufacturers are increasingly trying to meet the expectations of consumers who are aware [...] Read more.
Environmental protection has become one of the key challenges of our time. This has led to an increase in pro-environmental activities in the field of cosmetics and household chemicals, where manufacturers are increasingly trying to meet the expectations of consumers who are aware of the potential risks associated with the production of cosmetics and household chemistry products. This is one of the most important challenges of today’s industry, given that some of the raw materials still commonly used, such as surfactants, may be toxic to aquatic organisms. Many companies are choosing to use natural raw materials that have satisfactory performance properties but are also environmentally friendly. In addition, modern products are also characterized by reduced consumption of water, resources, and energy in production processes. These measures reduce the carbon footprint and reduce the amount of plastic packaging required. In the present study, seven formulations of environmentally friendly car shampoo concentrates were developed, based entirely on mixtures of bio-based surfactants. The developed formulations were tested for application on the car body surface, allowing the selection of the two best products. For these selected formulations, an in-depth physicochemical analysis was carried out, including pH, density, and viscosity measurements. Comparison of the results with commercial products available on the market was also performed. Additionally, using the multiple light scattering method, the foamability and foam stability were determined for the car shampoos developed. The results obtained indicate the very high application potential of the products under study, which combine high performance and environmental concerns. Full article
(This article belongs to the Section Environmental Aspects in Colloid and Interface Science)
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37 pages, 9057 KiB  
Review
Palaeoclimatic Geoheritage in the Age of Climate Change: Educational Use of the Pleistocene Glacial and Periglacial Geodiversity
by Paweł Wolniewicz and Maria Górska-Zabielska
Geosciences 2025, 15(8), 294; https://doi.org/10.3390/geosciences15080294 - 2 Aug 2025
Viewed by 336
Abstract
The lithological record of past climates and climate changes reveals significant potential in enhancing education and understanding of global climate changes and their impacts on contemporary societies. A relatively young geological record of Pleistocene cooling and glaciations serves as one of the most [...] Read more.
The lithological record of past climates and climate changes reveals significant potential in enhancing education and understanding of global climate changes and their impacts on contemporary societies. A relatively young geological record of Pleistocene cooling and glaciations serves as one of the most useful geo-educational tools. The present study encompasses a comprehensive review of ongoing efforts to assess and communicate the glacial geoheritage of the Pleistocene, with a detailed case study of Poland. A literature review is conducted to evaluate the extent of scientific work on inventorying and communicating the geodiversity of Pleistocene glacial and periglacial environments globally. The study demonstrates a steady increase in the number of scientific contributions focused on the evaluation and promotion of Pleistocene geoheritage, with a notable transition from the description of geosites to the establishment of geoconservation practices and educational strategies. The relative complexity of the palaeoclimatic record and the presence of glacial geodiversity features across extensive areas indicate that effective scientific communication of climate changes requires careful selection of a limited number of geodiversity elements and sediment types. In this context, the use of glacial erratic boulders and rock gardens for promotion of Pleistocene glacial geoheritage is advocated, and the significance of educational initiatives for local communities and the preservation of geocultural heritage is outlined in detail. Full article
(This article belongs to the Special Issue Challenges and Research Trends of Geoheritage and Geoconservation)
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29 pages, 1079 KiB  
Article
Electricity-Related Emissions Factors in Carbon Footprinting—The Case of Poland
by Anna Lewandowska, Katarzyna Joachimiak-Lechman, Jolanta Baran and Joanna Kulczycka
Energies 2025, 18(15), 4092; https://doi.org/10.3390/en18154092 - 1 Aug 2025
Viewed by 187
Abstract
Electricity is a significant factor in the life cycle of many products, so the reliability of greenhouse gas (GHG) emissions data is crucial. The article presents publicly available sources of emission factors representative of Poland. The aim of the study is to assess [...] Read more.
Electricity is a significant factor in the life cycle of many products, so the reliability of greenhouse gas (GHG) emissions data is crucial. The article presents publicly available sources of emission factors representative of Poland. The aim of the study is to assess their strengths and weaknesses in the context of the calculation requirements of carbon footprint analysis in accordance with the GHG Protocol. The article presents the results of carbon footprint calculations for different ranges of emissions in the life cycle of 1 kWh of electricity delivered to a hypothetical organization. Next, a discussion on the quality of the emissions factors has been provided, taking account of data quality indicators. It was concluded that two of the emissions factors that are compared—those based on the national consumption mix and the residual mix for Poland—have been recognized as suitable for use in carbon footprint calculations. Beyond the calculation results, the research highlights the significance of the impact of the selection of emissions factors on the reliability of environmental analysis. The article identifies methodological challenges, including the risk of double counting, limited transparency, methodological inconsistency, and low correlation of data with specific locations and technologies. The insights presented contribute to improving the robustness of carbon footprint calculations. Full article
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42 pages, 9817 KiB  
Article
Simulation Analysis of Onshore and Offshore Wind Farms’ Generation Potential for Polish Climatic Conditions
by Martyna Kubiak, Artur Bugała, Dorota Bugała and Wojciech Czekała
Energies 2025, 18(15), 4087; https://doi.org/10.3390/en18154087 - 1 Aug 2025
Viewed by 152
Abstract
Currently, Poland is witnessing a dynamic development of the offshore wind energy sector, which will be a key component of the national energy mix. While many international studies have addressed wind energy deployment, there is a lack of research that compares the energy [...] Read more.
Currently, Poland is witnessing a dynamic development of the offshore wind energy sector, which will be a key component of the national energy mix. While many international studies have addressed wind energy deployment, there is a lack of research that compares the energy and economic performance of both onshore and offshore wind farms under Polish climatic and spatial conditions, especially in relation to turbine spacing optimization. This study addresses that gap by performing a computer-based simulation analysis of three onshore spacing variants (3D, 4D, 5D) and four offshore variants (5D, 6D, 7D, 9D), located in central Poland (Stęszew, Okonek, Gostyń) and the Baltic Sea, respectively. The efficiency of wind farms was assessed in both energy and economic terms, using WAsP Bundle software and standard profitability evaluation metrics (NPV, MNPV, IRR). The results show that the highest NPV and MNPV values among onshore configurations were obtained for the 3D spacing variant, where the energy yield leads to nearly double the annual revenue compared to the 5D variant. IRR values indicate project profitability, averaging 14.5% for onshore and 11.9% for offshore wind farms. Offshore turbines demonstrated higher capacity factors (36–53%) compared to onshore (28–39%), with 4–7 times higher annual energy output. The study provides new insight into wind farm layout optimization under Polish conditions and supports spatial planning and investment decision making in line with national energy policy goals. Full article
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19 pages, 1584 KiB  
Article
Polymorphic Variants of Selected Genes Regulating Bile Acid Homeostasis in Women with Intrahepatic Cholestasis of Pregnancy
by Krzysztof Piątek, Grażyna Kurzawińska, Marcin Ożarowski, Piotr Józef Olbromski, Adam Kamiński, Maciej Brązert, Tomasz M. Karpiński, Wiesław Markwitz and Agnieszka Seremak-Mrozikiewicz
Int. J. Mol. Sci. 2025, 26(15), 7456; https://doi.org/10.3390/ijms26157456 - 1 Aug 2025
Viewed by 114
Abstract
Intrahepatic cholestasis of pregnancy (ICP) is characterized by the onset of pruritus and elevated serum transaminases and bile acids (BA). The key enzyme in BA synthesis is CYP7A1, and its functions are regulated by various nuclear receptors. The goal of this study is [...] Read more.
Intrahepatic cholestasis of pregnancy (ICP) is characterized by the onset of pruritus and elevated serum transaminases and bile acids (BA). The key enzyme in BA synthesis is CYP7A1, and its functions are regulated by various nuclear receptors. The goal of this study is to evaluate the association between CYP7A1, NR1H1, RXRA, and PPARA gene variants and risk of ICP. Five single nucleotide variants (SNVs), rs3808607 (CYP7A1), rs56163822 (NR1H4), rs1800206 (PPARA), rs749759, and rs11381416 (NR2B1), were genotyped in a group of 96 ICP and 211 controls. The T allele of the CYP7A1 (rs3808607) variant may be a protective factor against ICP risk (OR = 0.697, 95% CI: 0.495–0.981, p = 0.038). Genetic model analysis showed that rs3808607 was associated with decreased risk of ICP under dominant (OR = 0.55, 95% CI: 0.32–3.16, p = 0.032, AIC = 380.9) and log-additive models (OR = 0.71, 95% CI: 0.51–1.00, p = 0.046, AIC = 381.4). The A insertion in the rs11381416 NR2B1 variant was associated with the degree of elevation in the liver function tests TBA (34.3 vs. 18.8 μmol/L, p = 0.002), ALT (397.0 vs. 213.0 IU/L, p = 0.017), and AST (186.0 vs. 114.4 IU/L, p = 0.032) in ICP women. Results indicate an association between the CYP7A1 rs3808607 and the risk of ICP and the association of the rs11381416 of the NR2B1 receptor with higher values of liver function tests in women with ICP. A better understanding of the cooperation of proteins involved in BA metabolism may have important therapeutic implications in ICP and other hepatobiliary diseases. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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11 pages, 2025 KiB  
Article
Remarkable Stability of Uropodina (Acari: Mesostigmata) Communities in Artificial Microhabitats: A Case Study of Bird Nest Boxes in Bory Tucholskie National Park
by Marta Kulczak, Jacek Wendzonka, Karolina Lubińska, Agnieszka Napierała and Jerzy Błoszyk
Diversity 2025, 17(8), 544; https://doi.org/10.3390/d17080544 - 1 Aug 2025
Viewed by 161
Abstract
The presence of nest boxes not only increases the reproductive success of many passerine birds in transformed forest habitats, but they also constitute important artificial microhabitats for many groups of invertebrates. One of such groups which have been often found in this microhabitat [...] Read more.
The presence of nest boxes not only increases the reproductive success of many passerine birds in transformed forest habitats, but they also constitute important artificial microhabitats for many groups of invertebrates. One of such groups which have been often found in this microhabitat is saprophagous mites from the suborder Uropodina (Acari: Mesostigmata). The current study was conducted in October 2023 and 2024 in Bory Tucholskie National Park (BTNP) (northern Poland), where material from 137 tit (Paridae) and nuthatch (Sitta europaea) nest boxes was collected. The aim of this study was to analyse the stability of the communities of Uropodina in nest boxes in the park in two seasons and to determine whether the mite community structure within these nest boxes is similar in each year. The second aim was to analyse the abundance of Uropodina in relation to the composition of the nest box bedding material. This study revealed that the community in the scrutinised nest boxes was formed in both seasons by two species of nidicolous Uropodina species, i.e., Leiodinychus orbicularis (C.L. Koch, 1839) and Chiropturopoda nidiphila (Wiśniewski and Hirschmann, 1993), and that the species composition and the community structure were also very similar in both years. This study revealed that Ch. nidiphila dominated in the nest boxes with moss and grass, whereas L. orbicularis was most abundant in the boxes where the bedding was a mixture of mammalian hair and grass. However, no statistically significant differences in the abundance of these two mite species in both cases were revealed. Full article
(This article belongs to the Special Issue Diversity, Ecology, and Conservation of Mites)
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