You are currently viewing a new version of our website. To view the old version click .

4 Results Found

  • Article
  • Open Access
3 Citations
1,767 Views
17 Pages

A Bioconjugate Vaccine Against Extra-Intestinal Pathogenic Escherichia coli (ExPEC)

  • Linhui Hao,
  • Wenhua Huang,
  • Yan Guo,
  • Xiankai Liu,
  • Jun Wu,
  • Li Zhu,
  • Chao Pan and
  • Hengliang Wang

28 March 2025

Background: Extra-intestinal pathogenic Escherichia coli (ExPEC) represents a major global public health challenge due to its ability to cause diverse clinical infections, including urinary tract infections, bacteremia, neonatal meningitis, and sepsi...

  • Review
  • Open Access
2 Citations
2,421 Views
15 Pages

Recent Advances in Bioconjugate Vaccine Development

  • Brendan W. Wren,
  • Catherine L. Hall,
  • Vanessa S. Terra,
  • Mark A. Harrison,
  • Elizabeth Atkins,
  • Fauzy Nasher and
  • Ian J. Passmore

28 June 2025

Glycoconjugate vaccines, consisting of a protein component covalently linked to a glycan antigen, have led to a significant reduction in the global occurrence of bacterial meningitis and pneumonia. They provide robust, lasting immunity in all age gro...

  • Article
  • Open Access
7 Citations
3,256 Views
14 Pages

Genetic Engineering of Klebsiella pneumoniae ATCC 25955 for Bioconjugate Vaccine Applications

  • Yan Liu,
  • Shulei Li,
  • Yan Guo,
  • Xin Li,
  • Li Zhu,
  • Hengliang Wang,
  • Jun Wu and
  • Chao Pan

Vaccination is considered the most effective means to fight against the multidrug-resistant strains of Klebsiella pneumoniae. In recent years, a potential protein glycan coupling technology has been extensively used in the production of bioconjugated...

  • Article
  • Open Access
1,082 Views
19 Pages

7 March 2025

The rapid proliferation of the Internet of Things (IoT) poses significant challenges for utility optimization in sharding blockchain systems. In this paper, we propose a Committee Scheduling Algorithm (CSA), which employs an iterative optimization fr...