Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage t...
Resistance to antibiotics has made diseases that previously healed easily become more difficult to treat. Staphylococcus aureus is an important cause of hospital-acquired infections and multi-drug resistant. NorA efflux pump, present in bacteria S. a...
Among the bacterial resistance mechanisms, active efflux pumps play a role in the extrusion of different molecules, and, thus, contribute to antimicrobial resistance. Staphylococcus aureus is a Gram-positive bacterium that can present resistance to v...
Staphylococcus aureus can exhibit resistance to various antibiotics. Among its resistance mechanisms, the active efflux of antibiotics can be seen as relevant. This study aimed to evaluate the ability of resveratrol to modulate norfloxacin resistance...
Study of the novel RNA virus, Nora virus, which is a persistent, picorna-like virus that replicates in the gut of Drosophila melanogaster offers insight into human innate immunity and other picorna-like viruses. Nora virus infection leads to a locomo...
Drosophila melanogaster Nora virus (DmNV) is a novel picorna-like virus first characterized in 2006. Since then, Nora virus has been detected in several non-Drosophila species, including insects in the Orders Hymenoptera, Lepidoptera, Coleoptera, and...
The expression of the efflux pump systems is the most important mechanism of antibiotic resistance in bacteria, as it contributes to reduced concentration and the subsequent inactivity of administered antibiotics. NorA is one of the most studied anti...
In this paper, we discuss the presence of volcanic pozzolans in the structural mortars of the Roman Temple of Nora in Sardinia (3rd c. AD), represented by pyroclastic rocks (pumices and tuffs) employed as coarse and fine aggregates. The provenance of...
Introduction: Percutaneous ultrasound-guided radiofrequency ablation (RFA) is a well-studied treatment option for locally non-advanced hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLMs). Sedation is of crucial interest as it enabl...
The use and misuse of antibiotics has resulted in critical conditions for drug-resistant bacteria emergency, accelerating the development of antimicrobial resistance (AMR). In this context, the co-administration of an antibiotic with a compound able...
2 December 2021
The hypogea of the Punic necropolis of Nora represented a testing ground for the use of photogrammetry as an archaeological survey tool in a highly critical context, both from the point of view of the survey itself and from the point of view of the u...
Background: Uncooperative children require sedative approach for dental treatment. The aim was to assess the effectiveness of Propofol in “Non-Operating Room Anesthesia” (NORA) for paediatric dental treatment; intraoperative side effects; postoperati...
This essay argues that in Ibsen’s A Doll House, both Nora and her husband, Torvald Helmer, exhibit a “religion of Torvald” characterized by their respective devotion to Torvald himself. However, while Torvald’s devotion to him...
Background/Objectives: Hydrazones are organic compounds with the general structure R2C=NNHR1, distinguished by their versatility and modifiability, and are widely used in various applications due to their physicochemical and biological properties. Th...
In this work, a protocol of a partially invasive sampling for the archaeometric characterization of ancient mortars from the little Roman Bath of Nora (Sardinia, Italy) is presented. Optical microscopy and different analytical techniques such as X-ra...
Background: Peripherally inserted central catheters (PICCs) are widely used for medium- and long-term intravenous therapies but remain associated with mechanical and thrombotic complications, particularly during venipuncture and guidewire insertion....
Accurate wind resource assessment is critical for the effective planning of wind farms, as well as for forecasting production values to ensure grid stability, yet it remains a complex challenge. This study evaluates the robustness of the Norwegian re...
NorA is one of the main native MDR efflux pumps of Staphylococcus aureus, contributing to reduced susceptibility towards fluoroquinolones and biocides, but little is known about its variability within S. aureus or its distribution and conservation am...
Realizing autonomic management control loops is pivotal for achieving self-driving networks. Some studies have recently evidence the feasibility of using Automated Planning (AP) to carry out these loops. However, in practice, the use of AP is complic...
This article examines the depiction of multiple forms of marginalization and exclusion in a recent Chinese film, Like a Rolling Stone (2024), through the prism of noise at the interface of politics and aesthetics. It starts with interrogating th...
One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized t...
Introduction: Bacterial infections, especially those caused by multidrug-resistant strains, remain a major health concern. This study investigates 4-chlorobenzyl p-coumarate, assessing its antibacterial mechanism, pharmacokinetic profile, and potenti...
Bacterial resistance to antibiotics has become a public health issue around the world. The present study aimed to evaluate the antibacterial activity of chalcones isolated from flowers of Arrabidaea brachypoda, and their potential as efflux pump inhi...
Coumarins are compounds with scientifically proven antibacterial properties, and modifications to the chemical structure are known to improve their effects. This information is even more relevant with the unbridled advances of antibiotic resistance,...
Rising sea levels are mainly due to increases in environmental temperatures that are causing ice to melt. The weathering of geomaterials is mainly due to the increase in the concentration of greenhouse gases in the atmosphere. This research addresses...
The European Anaphylaxis Registry (NORA) was designed in order to create a comprehensive Anaphylaxis Registry regarding anaphylactic reactions characteristics and management in several European countries, including Greece. This study aims to analyze...
Mortality rates from pulmonary embolism (PE) remain significant, highlighting the need for alternative treatment strategies beyond traditional anticoagulation. Percutaneous interventions, including mechanical thrombectomy and catheter-directed thromb...
Background: Staphylococcus aureus is a highly lethal Gram-positive bacterium that is responsible for over one million deaths annually. As a member of the ESKAPE pathogens, its methicillin-resistant strains (MRSA) are prevalent worldwide and...
Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across th...
7 December 2021
In this work, we will describe the application of the Extended Matrix Framework (EMF) to the 3D reconstruction of the temple on the Roman forum of Nora. EMF represents a specific section of the Extended Matrix (EM) method, developed by the VHLab of t...
Valencene and nootkatone are aromatic sesquiterpenes with known biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor. Given the evidence that encapsulation into nanosystems, such as liposomes, could improve the...
The paper focuses on recent achievements in the search for new chemical compounds able to inhibit multidrug resistance (MDR) mechanisms in Gram-positive pathogens. An analysis of the results of the search for new efflux pump inhibitors (EPIs) for Gra...
Background/Objectives: Nivolumab monotherapy is a standard of care in previously treated advanced renal cell carcinoma (aRCC) and was approved based on the results of the randomized clinical trial Checkmate-025. The non-interventional study (NIS) NOR...
Polymeric composites, where bioactive species are immobilized on inorganic nanostructured matrix, have received considerable attention as surfaces able to reduce bacterial adherence, colonization, and biofilm formation in implanted medical devices. I...
Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. &a...
Background/Objectives: The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in Staphylococcus aureus strains expressing NorA and MepA efflux pumps....
Drosophila melanogaster has one of the best characterized antiviral immune responses among invertebrates. However, relatively few easily transmitted natural virus isolates are available, and so many Drosophila experiments have been performed using ar...
Although radiotherapy is a cornerstone in the management of several pediatric malignancies, its administration in children poses unique anesthetic challenges. Unlike adults, pediatric patients, particularly younger children, often require repeated se...
Bizarre parosteal osteochondromatous proliferation, or Nora's lesion, is a unique bony lesion that generally originates from the small bones of the hands and feet in young adults. We report a case of a bizarre parosteal osteochondromatous proliferati...
The Schiff base hydrazone ligand HL was prepared by the condensation reaction of 7-chloro-4-quinoline with o-hydroxyacetophenone. The ligand behaves either as monobasic bidentate or dibasic tridentate and contain ONN coordination sites. This was acco...
Nora's lesion, or bizarre parosteal osteochondromatous proliferation (BPOP), is a rare benign lesion that is made up of varying degrees of cartilage, bone, and spindle cells. Most notably, calcification of the cartilage or “blue bone,” is a feature o...
Historical hydraulic systems represent a significant part of landscapes and global heritage. However, from the second half of the 20th century onwards, substantial socio-economic as well as technological changes occurring worldwide have put them at r...
Non-operating room anesthesia (NORA) is a rapidly growing domain for anesthesia professionals due to advances in procedural technology and increased emphasis on patient comfort. The majority of these procedures are conducted under monitored anesthesi...
Sentinel-1 Synthetic Aperture Radar (SAR) is a multi-purpose monitoring satellite suite that, among many applications, provides sea surface wind speeds at high spatial resolution. The overall aim of the study is to quantify the accuracy of the SAR wi...
30 September 2022
Background: This study examined employer experience with SARS-CoV-2 (COVID-19) asymptomatic testing through a social marketing lens. Social marketing uses commercial marketing principles to achieve socially beneficial ends including improved health a...
1 January 2020
Neben der Ablehnung der Flüchtlinge, die in Deutschland nicht anders als in anderen Ländern in der verbreiteten Manifestation von Rassismus und Rechtextremismus sichtbar wird, ist die «Willkommenskultur» etwas Besonderes [...]
The high frequency of infectious diseases has spurred research into effective tactics to combat microorganisms that are resistant to several drugs. The overproduction of the transmembrane efflux pump protein NorA, which may export hydrophilic fluoroq...
A subungual exostosis is a benign lesion described as a variant of an osteochondroma. It mostly affects the great toe, and it can be confused with an osteochondroma and a Nora’s lesion. The curative treatment for a subungual exostosis is complete exc...
Background: The use of pediatric non-operating room anesthesia (NORA) has increased substantially, yet information regarding current practices in Saudi Arabia remains limited. This study assessed pediatric NORA practices, resources, and reported comp...
A 19-year-old woman presented with pain at the lateral side of the fifth toe of her left foot, which was separated from the adjacent toe. Initial examination suggested dislocation of the fifth metatarsophalangeal joint due to a past fracture. Radiogr...
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