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Article

6 Citations

2,633 Views

10 Pages

Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery

Kirill K. Geyl,
Svetlana O. Baykova,
Pavel A. Andoskin,
Vladimir V. Sharoyko,
Anastasiya A. Eliseeva,
Sergey V. Baykov,
Konstantin N. Semenov and
Vadim P. Boyarskiy

Inorganics2022, 10(12), 247;https://doi.org/10.3390/inorganics10120247

7 December 2022

Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes. We synthesized two palladium(II) and two platinum(II) cyclometallated species wi...

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9 Citations

3,031 Views

16 Pages

Synthesis of 3-(Pyridin-2-yl)quinazolin-2,4(1H,3H)-diones via Annulation of Anthranilic Esters with N-pyridyl Ureas

Svetlana O. Baykova,
Kirill K. Geyl,
Sergey V. Baykov and
Vadim P. Boyarskiy

Int. J. Mol. Sci.2023, 24(8), 7633;https://doi.org/10.3390/ijms24087633

21 April 2023

A new route for the synthesis of quinazolin-2,4(1H,3H)-diones and thieno [2,3-d]pyrimidine-2,4(1H,3H)-diones substituted by pyridyl/quinolinyl moiety in position 3 has been developed. The proposed method concluded in an annulation of substituted anth...

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Article

36 Citations

6,748 Views

13 Pages

Novel Pyranopyrazoles: Synthesis and Theoretical Studies

Ahmed A. Al-Amiery,
Redah I. Al-Bayati,
Fouad M. Saed,
Wassan B. Ali,
Abdul Amir H. Kadhum and
Abu Bakar Mohamad

Molecules2012, 17(9), 10377-10389;https://doi.org/10.3390/molecules170910377

30 August 2012

A series of pyranopyrazoles, namely, 7-(2-aminoethyl)-3,4-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one (2), (Z)-3,4-dimethyl-1-(4-((4-nitrobenzylidene)amino)phenyl)pyrano[2,3-c]pyrazol-6(1H)-one (5), 1-(4-(3,4-dimethyl-6-oxopyrano[2,3-c]pyra...

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94 Citations

8,757 Views

13 Pages

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

Mohammad Emad Azab,
Mohamed M. Youssef and
Eman A. El-Bordany

Molecules2013, 18(1), 832-844;https://doi.org/10.3390/molecules18010832

11 January 2013

Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of acti...

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2,137 Views

13 Pages

Discovery of Novel Pyridin-2-yl Urea Inhibitors Targeting ASK1 Kinase and Its Binding Mode by Absolute Protein–Ligand Binding Free Energy Calculations

Lingzhi Wang,
Yalei Gao,
Yuying Chen,
Zhenzhou Tang,
Xiao Lin,
Meng Bai,
Pei Cao and
Kai Liu

Int. J. Mol. Sci.2025, 26(4), 1527;https://doi.org/10.3390/ijms26041527

12 February 2025

Apoptosis signal-regulating kinase 1 (ASK1), a key component of the mitogen-activated protein kinase (MAPK) cascades, has been identified as a promising therapeutic target owing to its critical role in signal transduction pathways. In this study, we...

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10 Citations

5,189 Views

13 Pages

Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds

Mohammad M. Al-Sanea,
Mohammed Safwan Ali Khan,
Ahmed Z. Abdelazem,
So Ha Lee,
Pooi Ling Mok,
Mohammed Gamal,
Mohamed E. Shaker,
Muhammad Afzal,
Bahaa G. M. Youssif and
Nesreen Nabil Omar

Molecules2018, 23(2), 297;https://doi.org/10.3390/molecules23020297

31 January 2018

A new series of 1-phenyl-3-(4-(pyridin-3-yl)phenyl)urea derivatives were synthesized and subjected to in vitro antiproliferative screening against National Cancer Institute (NCI)-60 human cancer cell lines of nine different cancer types. Fourteen com...

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