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15,456 Results Found

  • Article
  • Open Access
2 Citations
4,424 Views
23 Pages

28 February 2021

Healing is the basis of belief in San Lázaro, a popular saint among Cubans, Cuban-Americans, and other Latinx peoples. Stories about healing, received through faith in San Lázaro, are typically passed on through family members, rendering them genealo...

  • Article
  • Open Access
4,450 Views
12 Pages

Treatment of Wounds That Are Difficult to Heal with Photobiomodulation: A Pilot Study

  • Sara De Angelis,
  • Alessio Conti,
  • Antonella Di Nunzio,
  • Patrizia Stoppa,
  • Fabiano Zanchi and
  • Valerio Dimonte

Background/Objectives: Hard-to-heal wounds are resistant to standard treatments and significantly impact patients’ quality of life and healthcare costs. Photobiomodulation with blue light has shown potential in wound healing, but evidence in wo...

  • Review
  • Open Access
8 Citations
3,665 Views
23 Pages

A Host-Directed Approach to the Detection of Infection in Hard-to-Heal Wounds

  • Michael Burnet,
  • Daniel G. Metcalf,
  • Scarlet Milo,
  • Clemens Gamerith,
  • Andrea Heinzle,
  • Eva Sigl,
  • Kornelia Eitel,
  • Marieke Haalboom and
  • Philip G. Bowler

4 October 2022

Wound infection is traditionally defined primarily by visual clinical signs, and secondarily by microbiological analysis of wound samples. However, these approaches have serious limitations in determining wound infection status, particularly in early...

  • Article
  • Open Access
19 Citations
4,133 Views
12 Pages

Thermal Effects of Topical Hyperbaric Oxygen Therapy in Hard-to-Heal Wounds—A Pilot Study

  • Teresa Kasprzyk-Kucewicz,
  • Armand Cholewka,
  • Beata Englisz-Jurgielewicz,
  • Romualda Mucha,
  • Michał Relich,
  • Marek Kawecki,
  • Karolina Sieroń,
  • Patrycja Onak and
  • Agata Stanek

Clinical studies have been performed to evaluate the thermal response of topical hyperbaric oxygen therapy (THBOT) in patients suffering from hard-to-heal wounds diagnosed as venous leg ulcers located on their lower extremities. It was found that thi...

  • Article
  • Open Access
16 Citations
3,392 Views
16 Pages

Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds

  • Patrik Stenlund,
  • Linnea Enstedt,
  • Karin Margaretha Gilljam,
  • Simon Standoft,
  • Astrid Ahlinder,
  • Maria Lundin Johnson,
  • Henrik Lund,
  • Anna Millqvist Fureby and
  • Mattias Berglin

9 June 2023

Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topic...

  • Article
  • Open Access
7 Citations
3,475 Views
14 Pages

Hard-to-Heal Wound Healing: Superiority of Hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a Standard Hydrogel. A Randomized Controlled Trial

  • José Verdú-Soriano,
  • Antonio Casado-Díaz,
  • Marisol de Cristino-Espinar,
  • Silvia Luna-Morales,
  • Caridad Dios-Guerra,
  • Paloma Moreno-Moreno,
  • Gabriel Dorado,
  • José Manuel Quesada-Gómez,
  • Leocadio Rodríguez-Mañas and
  • José Luis Lázaro-Martínez

8 December 2023

Chronic wounds, especially those that are hard-to-heal, constitute a serious public-health problem. Although progress has been made in the development of wound dressings for healing, there is little high-quality evidence of their efficacy, with no ev...

  • Communication
  • Open Access
11 Citations
3,698 Views
12 Pages

20 May 2021

As stiff polymers are difficult to self-heal, the balance between polymers’ self-healing ability and mechanical properties is always a big challenge. Herein, we have developed a novel healable stiff polymer based on the Si-OR and Si-OSi dynamic coval...

  • Article
  • Open Access
16 Citations
5,266 Views
16 Pages

Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

  • Renan Aparecido Fernandes Scappaticci,
  • Andresa Aparecida Berretta,
  • Elina Cassia Torres,
  • Andrei Felipe Moreira Buszinski,
  • Gabriela Lopes Fernandes,
  • Thaila Fernanda dos Reis,
  • Francisco Nunes de Souza-Neto,
  • Luiz Fernando Gorup,
  • Emerson Rodrigues de Camargo and
  • Debora Barros Barbosa

3 November 2021

Infected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After w...

  • Article
  • Open Access
903 Views
18 Pages

Injectable Hyaluronic Acid and Amino Acids Complex for Pediatric Hard-to-Heal Wounds: A Prospective Case Series and Therapeutic Protocol

  • Guido Ciprandi,
  • Biagio Nicolosi,
  • Gabriele Storti,
  • Simone F. Marino,
  • Carlotta Scarpa and
  • Franco Bassetto

17 November 2025

Background: Pediatric hard-to-heal wounds are rare but clinically demanding due to skin immaturity, comorbidities, and infection risk. Methods: This prospective case series evaluated the feasibility, safety, and clinical outcomes of an injectable hya...

  • Article
  • Open Access
3 Citations
1,057 Views
13 Pages

26 September 2025

Background/Objectives: Treatment of hard-to-heal wounds remains a challenge in clinical practice. This study aimed to assess the real-world efficacy of a novel porcine placental extracellular matrix (PPECM; InnovaMatrix® AC, Convatec, Memphis, TN...

  • Article
  • Open Access
1 Citations
2,360 Views
13 Pages

The Vascularized Fibula as Salvage Procedure in Extremity Reconstruction: A Retrospective Analysis of Time to Heal and Possible Confounders

  • Christian Smolle,
  • Judith C. J. Holzer-Geissler,
  • Patrick Mandal,
  • Jessica Schwaller,
  • Gert Petje,
  • Johannes Rois,
  • Lars-Peter Kamolz and
  • Werner Girsch

28 February 2024

The vascularized fibula transfer is a well-established technique for extremity reconstruction, but operative planning and patient selection remains crucial. Although recently developed techniques for bone reconstruction, such as bone segment transfer...

  • Communication
  • Open Access
6 Citations
3,456 Views
10 Pages

The fields of polymer science, conductive composites, materials engineering, robotics, and human perception intersect at the development and application of synthetic human skin. To be accepted by human users, artificial human skin must meet several r...

  • Article
  • Open Access
2 Citations
1,586 Views
27 Pages

Accurate AI-Based Characterization of Wound Size and Tissue Composition in Hard-to-Heal Wounds

  • Karl Lindborg,
  • Matilda Karlsson,
  • Ana Kotorri,
  • Folke Sjöberg,
  • Mats Fredrikson,
  • Axel Haglind,
  • Zacharias Sjöberg and
  • Moustafa Elmasry

18 August 2025

Background: Detailed assessments, documentation, and evaluation of the wound characteristics in hard-to-heal wounds are essential for optimizing and individualizing wound care. However, the remaining challenge in clinical care includes the lack of hi...

  • Article
  • Open Access
24 Citations
4,818 Views
18 Pages

Effect of Healing Agents on Crack Healing of Asphalt and Asphalt Mortar

  • Changluan Pan,
  • Ping Tang,
  • Martin Riara,
  • Liantong Mo,
  • Mingliang Li and
  • Meng Guo

7 August 2018

This study investigated the effect of seven healing agents on crack healing ability of long-term aged asphalt and its mortar. Different healing agents including sunflower oil, aromatic oil, bitumen emulsion, and maltene-based emulsions were used. The...

  • Article
  • Open Access
2 Citations
1,858 Views
21 Pages

Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal?

  • Jéssica Leite-Silva,
  • Carla Oliveira-Ribeiro,
  • Fernanda Nazaré Morgado,
  • Maria Inês Fernandes Pimentel,
  • Marcelo Rosandiski Lyra,
  • Aline Fagundes,
  • Luciana Freitas Campos Miranda,
  • Claudia Maria Valete-Rosalino,
  • Armando Oliveira Schubach and
  • Fátima Conceição-Silva

Localized cutaneous leishmaniasis caused by Leishmania braziliensis can either respond well or poorly to the treatment or heal spontaneously; It seems to be dependent on the parasite and/or host factors, but the mechanisms are not fully understood. W...

  • Article
  • Open Access
32 Citations
4,953 Views
16 Pages

Prediction of Healing Performance of Autogenous Healing Concrete Using Machine Learning

  • Xu Huang,
  • Mirna Wasouf,
  • Jessada Sresakoolchai and
  • Sakdirat Kaewunruen

21 July 2021

Cracks typically develop in concrete due to shrinkage, loading actions, and weather conditions; and may occur anytime in its life span. Autogenous healing concrete is a type of self-healing concrete that can automatically heal cracks based on physica...

  • Article
  • Open Access
9 Citations
3,223 Views
15 Pages

Evaluation of Cyclic Healing Potential of Bacteria-Based Self-Healing Cementitious Composites

  • Ismael Justo-Reinoso,
  • Bianca J. Reeksting,
  • Andrew Heath,
  • Susanne Gebhard and
  • Kevin Paine

3 June 2022

At present, little evidence exists regarding the capability of bacteria-based self-healing (BBSH) cementitious materials to successfully re-heal previously healed cracks. This paper investigates the repeatability of the self-healing of BBSH mortars w...

  • Article
  • Open Access
28 Citations
4,844 Views
16 Pages

25 July 2021

The amounts of the components in a microcapsule self-healing system significantly impact the basic performance and self-healing performance of concrete. In this paper, an orthogonal experimental design is used to investigate the healing performance o...

  • Review
  • Open Access
24 Citations
7,228 Views
34 Pages

22 November 2018

Over the last several years, self-healing materials have become more and more popular in terms of damage reparation. Moreover, a recent theoretical investigation of super healing materials that aims at repairing and strengthening itself was also deve...

  • Article
  • Open Access
2 Citations
2,009 Views
18 Pages

Choice of Healing Agent for Self-Healing Asphalt Concrete

  • Sergei Sergeevich Inozemtcev,
  • Evgeniy Valerievich Korolev and
  • Trong Toan Do

7 December 2023

The choice of a substance as a healing agent for asphalt concrete is determined by the scientific experience of researchers and the results of exploratory studies. There are no standard approaches for selecting healing agents or assessing their compa...

  • Review
  • Open Access
3 Citations
1,498 Views
14 Pages

8 October 2025

Self-healing hydrogels, a novel class of “smart” hydrogels, possess the ability to autonomously restore their network structure and mechanical properties following damage through the reconnection of a fractured three-dimensional network v...

  • Article
  • Open Access
1 Citations
2,103 Views
15 Pages

Performance of Self-Healing Cementitious Composites Using Aligned Tubular Healing Fiber

  • Ru Mu,
  • Dogniman Landry Soro,
  • Xiaowei Wang,
  • Longbang Qing,
  • Guorui Cao,
  • Shaolin Mei and
  • Yongshuai Liu

18 October 2021

From the perspective of improving the self-healing method in construction, a tubular healing fiber was adopted as a container to improve the encapsulation capacity, which was available using a micro-capsule as a container. Knowing the direction of th...

  • Review
  • Open Access
1,485 Views
18 Pages

31 August 2025

Superhydrophilic surfaces have important applications in fields such as energy, military, and medicine due to their unique wettability. However, the micro-/nano-structures of superhydrophilic surfaces are fragile and prone to damage, which can cause...

  • Article
  • Open Access
30 Citations
3,991 Views
21 Pages

An Investigation of Suitable Healing Agents for Vascular-Based Self-Healing in Cementitious Materials

  • Yasmina Shields,
  • Tim Van Mullem,
  • Nele De Belie and
  • Kim Van Tittelboom

23 November 2021

Self-healing cementitious materials can extend the service life of structures, improve safety during repair activities and reduce costs with minimal human intervention. Recent advances in self-healing research have shown promise for capsule-based and...

  • Article
  • Open Access
31 Citations
5,753 Views
8 Pages

Dual Monitoring of Cracking and Healing in Self-healing Coatings Using Microcapsules Loaded with Two Fluorescent Dyes

  • Young Kyu Song,
  • Tae Hee Lee,
  • Jin Chul Kim,
  • Kyu Cheol Lee,
  • Sang-Ho Lee,
  • Seung Man Noh and
  • Young Il Park

30 April 2019

We report the development of an extrinsic, self-healing coating system that shows no fluorescence from intact coating, yellowish fluorescence in cracked regions, and greenish fluorescence in healed regions, thus allowing separate monitoring of cracki...

  • Article
  • Open Access
8 Citations
2,770 Views
16 Pages

30 April 2023

A new device and procedure for the in situ quantification of the extent of the self-healing and the kinetics of self-healing of polymeric materials were proposed. The device consisted of flowing an inert gas below the sample placed in a hermetically...

  • Review
  • Open Access
56 Citations
16,072 Views
40 Pages

Self-Healing Materials for Electronics Applications

  • Fouzia Mashkoor,
  • Sun Jin Lee,
  • Hoon Yi,
  • Seung Man Noh and
  • Changyoon Jeong

Self-healing materials have been attracting the attention of the scientists over the past few decades because of their effectiveness in detecting damage and their autonomic healing response. Self-healing materials are an evolving and intriguing field...

  • Article
  • Open Access
6 Citations
2,072 Views
19 Pages

6 May 2023

The self-healing ability of asphalt–aggregate bonding interfaces can maintain the mechanical properties of asphalt mixtures. However, the interface’s healing ability will also be affected by moisture and aging. In order to clarify the inf...

  • Article
  • Open Access
2 Citations
2,185 Views
12 Pages

Background: Demand for urban forest programs for the healing of cancer survivors is increasing. To develop a forest healing program for the integrated care of cancer patients, it is necessary to analyze the experiences of forest healing instructors w...

  • Article
  • Open Access
7 Citations
2,634 Views
12 Pages

Microcapsule-Type Self-Healing Protective Coating That Can Maintain Its Healed State upon Crack Expansion

  • Ji-Sun Lee,
  • Hyun-Woo Kim,
  • Jun-Seo Lee,
  • Hyun-Soo An and
  • Chan-Moon Chung

19 October 2021

The purpose of this study was to develop a microcapsule-type self-healing coating system that could self-heal cracks and then maintain the healed state even upon crack expansion. Mixtures consisting of a photoinitiator and two methacrylate components...

  • Article
  • Open Access
107 Citations
7,664 Views
23 Pages

A Novel Design of Autonomously Healed Concrete: Towards a Vascular Healing Network

  • Pieter Minnebo,
  • Glenn Thierens,
  • Glenn De Valck,
  • Kim Van Tittelboom,
  • Nele De Belie,
  • Danny Van Hemelrijck and
  • Eleni Tsangouri

8 January 2017

Concrete is prone to crack formation in the tensile zone, which is why steel reinforcement is introduced in these zones. However, small cracks could still arise, which give liquids and gasses access to the reinforcement causing it to corrode. Self-he...

  • Article
  • Open Access
15 Citations
3,062 Views
18 Pages

12 August 2022

Calcium alginate capsules encapsulating rejuvenator are a promising self-healing technology for asphalt pavement, but the effects of different healing agents on the self-healing performance of asphalt concrete has not been considered. In view of this...

  • Article
  • Open Access
2 Citations
1,503 Views
16 Pages

The Use of Virtual Reality as a Non-Pharmacological Approach for Pain Reduction During the Debridement and Dressing of Hard-to-Heal Wounds

  • Dariusz Bazaliński,
  • Anna Wójcik,
  • Kamila Pytlak,
  • Julia Bryła,
  • Ewa Kąkol,
  • Dawid Majka and
  • Julia Dzień

13 June 2025

Background/Objectives: Pain management during minor surgical procedures in wound care across various etiologies is often underestimated in daily clinical practice. Pharmacotherapy remains the most effective and efficient method for pain reduction. Ho...

  • Review
  • Open Access
16 Citations
4,613 Views
22 Pages

28 October 2022

Cementitious composites often crack because of their low tensile strength. The ability of self-healing cementitious composite to automatically repair cracks has attracted widespread attention. Lightweight aggregate (LWA) has a low density and a high...

  • Article
  • Open Access
4 Citations
2,791 Views
18 Pages

Healing patterns are a critical issue that influence the fracture mechanism of self-healing concrete (SHC) structures. Partial healing cracks could happen even during the normal operating conditions of the structure, such as sustainable applied loads...

  • Review
  • Open Access
71 Citations
14,527 Views
39 Pages

Self-Healing of Polymers and Polymer Composites

  • Vadim I. Irzhak,
  • Igor E. Uflyand and
  • Gulzhian I. Dzhardimalieva

9 December 2022

This review is devoted to the description of methods for the self-healing of polymers, polymer composites, and coatings. The self-healing of damages that occur during the operation of the corresponding structures makes it possible to extend the servi...

  • Article
  • Open Access
16 Citations
4,640 Views
11 Pages

Healing Performance of a Self-Healing Protective Coating According to Damage Width

  • Dong-Min Kim,
  • Junseo Lee,
  • Ju-Young Choi,
  • Seung-Won Jin,
  • Kyeong-Nam Nam,
  • Hyeong-Ju Park,
  • Seung-Hyun Lee and
  • Chan-Moon Chung

Although self-healing protective coatings have been widely studied, systematic research on healing performance of the coating according to damage width has been rare. In addition, there has been rare reports of self-healing of the protective coating...

  • Article
  • Open Access
4 Citations
3,818 Views
12 Pages

Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds

  • Jana Pecová,
  • Vladimíra Rohlíková,
  • Markéta Šmoldasová and
  • Jan Marek

Hard-to-heal wounds do not heal spontaneously and need long-term care provided by specialists. That burdens the patients as well as the healthcare systems. Such wounds arise from several pathologies, which result in venous leg ulcers (VLU), diabetic...

  • Review
  • Open Access
139 Citations
27,154 Views
46 Pages

Self-Healing Concrete as a Prospective Construction Material: A Review

  • Mugahed Amran,
  • Ali M. Onaizi,
  • Roman Fediuk,
  • Nikolai Ivanovicn Vatin,
  • Raizal Saifulnaz Muhammad Rashid,
  • Hakim Abdelgader and
  • Togay Ozbakkaloglu

29 April 2022

Concrete is a material that is widely used in the construction market due to its availability and cost, although it is prone to fracture formation. Therefore, there has been a surge in interest in self-healing materials, particularly self-healing cap...

  • Review
  • Open Access
5 Citations
4,448 Views
41 Pages

Self-Healing, Electroconductive Hydrogels for Wound Healing Applications

  • Duarte Almeida,
  • Diogo Dias,
  • Frederico Castelo Ferreira and
  • Teresa Esteves

8 August 2025

Electroconductive, self-healing hydrogels have surfaced as a versatile tool for advanced wound care applications, since they combine classic hydrogels’ moist and biomimetic environment with the dynamic electrical responsiveness that can functio...

  • Article
  • Open Access
9 Citations
2,770 Views
15 Pages

5 April 2022

Conductive alginate capsules encapsulating a bitumen rejuvenator (HealRoad capsules) has demonstrated good healing abilities in pure bitumen and mortar mixes. HealRoad capsules can efficiently heal damage via induction heating. They also release the...

  • Review
  • Open Access
27 Citations
6,208 Views
21 Pages

Advances and Challenges of Self-Healing Elastomers: A Mini Review

  • Jun Xu,
  • Lei Zhu,
  • Yongjia Nie,
  • Yuan Li,
  • Shicheng Wei,
  • Xu Chen,
  • Wenpeng Zhao and
  • Shouke Yan

30 August 2022

In the last few decades, self-healing polymeric materials have been widely investigated because they can heal the damages spontaneously and thereby prolong their service lifetime. Many ingenious synthetic procedures have been developed for fabricatin...

  • Article
  • Open Access
5 Citations
15,527 Views
30 Pages

Prayer and Healing: A Study of 83 Healing Reports in the Netherlands

  • Dirk Kruijthoff,
  • Elena Bendien,
  • Kees van der Kooi,
  • Gerrit Glas and
  • Tineke Abma

3 November 2022

The setting: 83 reports of healing related to prayer (HP) were evaluated between 2015 and 2020 in the Netherlands. Research questions: What are the medical and experiential findings? Do we find medically remarkable and/or medically unexplained healin...

  • Review
  • Open Access
26 Citations
13,293 Views
26 Pages

Recent Advances of Self-Healing Materials for Civil Engineering: Models and Simulations

  • Cen-Ying Liao,
  • Lin Zhang,
  • Si-Yu Hu,
  • Shuai-Jie Xia and
  • D. M. Li

Empowering materials with self-healing capabilities is an attractive approach for sustainable development. This strategy involves using different methods to automatically heal microcracks and damages that occur during the service life of materials or...

  • Article
  • Open Access
4 Citations
3,844 Views
29 Pages

19 June 2022

In this study, based upon the investigation of its effect on workability and the mechanical property of cementitious materials, the Box–Behnken design was adopted to establish models describing self-healing performance on mechanical properties...

  • Article
  • Open Access
4 Citations
2,980 Views
12 Pages

30 December 2022

The aging and damage of artificial skin materials for artificial intelligence robots are technical problems that need to be solved urgently in their application. In this work, poly (vinylidene fluoride) (PVDF) fibers containing a liquid agent were fa...

  • Article
  • Open Access
5 Citations
2,799 Views
13 Pages

17 July 2022

The purpose of this study is to investigate the healing performance of solid capsules made of cement as a basis for manufacturing self-healing capsules that can heal cracks in cementitious composites. The solid capsules were mixed with 5%, 10%, and 1...

  • Article
  • Open Access
37 Citations
4,474 Views
15 Pages

Crack-Resistance Behavior of an Encapsulated, Healing Agent Embedded Buffer Layer on Self-Healing Thermal Barrier Coatings

  • Dowon Song,
  • Taeseup Song,
  • Ungyu Paik,
  • Guanlin Lyu,
  • Yeon-Gil Jung,
  • Baig-Gyu Choi,
  • In-Soo Kim and
  • Jing Zhang

In this work, a novel thermal barrier coating (TBC) system is proposed that embeds silicon particles in coating as a crack-healing agent. The healing agent is encapsulated to avoid unintended reactions and premature oxidation. Thermal durability of t...

  • Article
  • Open Access
1 Citations
2,246 Views
10 Pages

19 June 2024

A self-healing gel with self-healing kinetics that can be regulated by heat is developed. The gel is composed of a polymer having benzophenone (BP) substituents, which are cross-linked with a main alkyl chain via ester bonds, titanium chloride, and z...

  • Review
  • Open Access
66 Citations
19,745 Views
19 Pages

Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders

  • Elisabeth Hofmann,
  • Julia Fink,
  • Anna-Lisa Pignet,
  • Anna Schwarz,
  • Marlies Schellnegger,
  • Sebastian P. Nischwitz,
  • Judith C. J. Holzer-Geissler,
  • Lars-Peter Kamolz and
  • Petra Kotzbeck

Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has cont...

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