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Article

4 Citations

2,529 Views

15 Pages

Stepwise Reduction of Mycophenolate Mofetil with Conversion to Everolimus for the Treatment of Active BKV in Kidney Transplant Recipients: A Single-Center Experience in Vietnam

Truong Quy Kien,
Nguyen Xuan Kien,
Le Viet Thang,
Phan Ba Nghia,
Diem Thi Van,
Nguyen Van Duc,
Do Manh Ha,
Nguyen Thi Thuy Dung,
Nguyen Thi Thu Ha and
Vu Thi Loan
+ 6 authors

J. Clin. Med.2022, 11(24), 7297;https://doi.org/10.3390/jcm11247297

8 December 2022

Background: No specific antiviral drug can effectively treat BKV reactivation after kidney transplantation. Thus, we evaluated stepwise-reduced immunosuppression to treat BKV reactivation. Methods: 341 kidney-transplant recipients were monitored for...

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Article

2 Citations

3,366 Views

20 Pages

CC Genotype of GNAS c.393C>T (rs7121) Polymorphism Has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant

Tobias Peitz,
Birte Möhlendick,
Ute Eisenberger,
Winfried Siffert,
Falko Markus Heinemann,
Andreas Kribben and
Justa Friebus-Kardash

Pathogens2022, 11(10), 1138;https://doi.org/10.3390/pathogens11101138

1 October 2022

The GNAS gene encodes the alpha-subunit of the stimulatory G-protein (Gαs) in humans and mice. The single-nucleotide polymorphism of GNAS, c.393C>T, is associated with an elevated production of Gαs and an increased formation of cyclic...

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Article

3 Citations

3,397 Views

13 Pages

Genomic Mutations of BK Polyomavirus in Patients after Kidney Transplantation: A Cross-Sectional Study in Vietnam

Truong Quy Kien,
Pham Quoc Toan,
Phan Ba Nghia,
Diem Thi Van,
Nguyen Van Duc,
Do Manh Ha,
Nguyen Thi Thuy Dung,
Nguyen Thi Thu Ha,
Le Thi Bao Quyen and
Hoang Trung Vinh
+ 5 authors

J. Clin. Med.2022, 11(9), 2544;https://doi.org/10.3390/jcm11092544

1 May 2022

Objectives: The purpose of this study was to identify the SNP sites and determine the BKV genotype circulating in kidney-transplant Vietnamese recipients based on the VP1 gene region. Methods: 344 samples were collected from post-kidney-transplant re...

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Abstract

1,523 Views

1 Page

BKTyper—Web Application for VP1 and NCCR Polyoma BK Typing

Joan Martí-Carreras and
Piet Maes

Proceedings2020, 50(1), 25;https://doi.org/10.3390/proceedings2020050025

9 June 2020

Human polyoma BK virus (BKV) prevalence has been increasing due to the introduction of more potent immunosuppressive agents, mostly in immunocompromised patients. BKV has been linked mostly to polyomavirus-associated hemorrhagic cystitis, and polyoma...

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Review

20 Citations

4,380 Views

21 Pages

The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation

Marija Burek Kamenaric,
Vanja Ivkovic,
Ivana Kovacevic Vojtusek and
Renata Zunec

Viruses2020, 12(12), 1417;https://doi.org/10.3390/v12121417

9 December 2020

BK virus (BKV) is a polyomavirus with high seroprevalence in the general population with an unremarkable clinical presentation in healthy people, but a potential for causing serious complications in immunosuppressed transplanted patients. Reactivatio...

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Article

4 Citations

3,006 Views

15 Pages

Lessons from Polyomavirus Immunofluorescence Staining of Urinary Decoy Cells

Sahra Pajenda,
Zsofia Hevesi,
Michael Eder,
Daniela Gerges,
Monika Aiad,
Oliver Koldyka,
Wolfgang Winnicki,
Ludwig Wagner,
Farsad Eskandary and
Alice Schmidt

Life2023, 13(7), 1526;https://doi.org/10.3390/life13071526

7 July 2023

Decoy cells that can be detected in the urine sediment of immunosuppressed patients are often caused by the uncontrolled replication of polyomaviruses, such as BK-Virus (BKV) and John Cunningham (JC)-Virus (JCV), within the upper urinary tract. Due t...

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