Search Results (691)

With the electrification of generator sets, electric locomotives, new energy vehicles, and other industries, AC motors subject bearings to an electric field environment, leading to galvanic corrosion due to the use of variable frequency power supply drives. The phenomenon of bearing discharge breakdown in subway traction motors is a critical issue in understanding the relationship between shaft current strength and the extent of bearing damage. This paper analyzes the mechanism of impulse discharge that leads to galvanic corrosion damage in bearings at a microscopic level and conducts electric thermal coupling simulations of the traction motor bearing discharge breakdown process. It examines the temperature rise associated with lubricant film discharge breakdown during the dynamic operation of the bearing and investigates how breakdown channel parameters and operational conditions affect the temperature rise in the micro-region of bearing lubrication. Ultimately, the results of the electric thermal coupling simulation are validated through experimental tests. This study revealed that in an electric field environment, the load-bearing area of the outer ring experiences significantly more severe corrosion damage than the inner ring, whereas non-bearing areas remain unaffected by electrolytic corrosion. When the inner ring reaches a speed of 4500_rpm, the maximum widths of electrolytic corrosion pits for the outer and inner rings are measured at 89 um and 51 um, respectively. Additionally, the highest recorded temperatures for the breakdown channels in the outer and inner rings are 932 °C and 802 °C, respectively. Furthermore, as the inner ring speed increases, both the width of the electrolytic corrosion pits and the temperature of the breakdown channels rise. Specifically, at inner ring speeds of 2500_rpm, 3500_rpm, and 4500_rpm, the widths of the electrolytic pits in the outer ring raceway load zone were measured at 34 um, 56 um, and 89 um, respectively. The highest temperatures of the lubrication film breakdown channels were recorded as 612 °C, 788 °C, and 932 °C, respectively. This study provides a theoretical basis and data support for the protective and maintenance practices of traction motor bearings. Full article

Background: The candidate therapeutic peptide TnP demonstrates broad, system-level regulatory capacity, revealed through integrated network analysis from transcriptomic data in zebrafish. Our study primarily identifies TnP as a multifaceted modulator of drug metabolism, wound healing, proteolytic activity, and pigmentation pathways. Results: Transcriptomic profiling of TnP-treated larvae following tail fin amputation revealed 558 differentially expressed genes (DEGs), categorized into four functional networks: (1) drug-metabolizing enzymes (cyp3a65, cyp1a) and transporters (SLC/ABC families), where TnP alters xenobiotic processing through Phase I/II modulation; (2) cellular trafficking and immune regulation, with upregulated myosin genes (myhb/mylz3) enhancing wound repair and tlr5-cdc42 signaling fine-tuning inflammation; (3) proteolytic cascades (c6ast4, prss1) coupled to autophagy (ulk1a, atg2a) and metabolic rewiring (g6pca.1-tg axis); and (4) melanogenesis-circadian networks (pmela/dct-fbxl3l) linked to ubiquitin-mediated protein turnover. Key findings highlight TnP’s unique coordination of rapid (protease activation) and sustained (metabolic adaptation) responses, enabled by short network path lengths (1.6–2.1 edges). Hub genes, such as nr1i2 (pxr), ppara, and bcl6aa/b, mediate crosstalk between these systems, while potential risks—including muscle hypercontractility (myhb overexpression) or cardiovascular effects (ace2-ppp3ccb)—underscore the need for targeted delivery. The zebrafish model validated TnP-conserved mechanisms with human relevance, particularly in drug metabolism and tissue repair. TnP’s ability to synchronize extracellular matrix remodeling, immune resolution, and metabolic homeostasis supports its development for the treatment of fibrosis, metabolic disorders, and inflammatory conditions. Conclusions: Future work should focus on optimizing tissue-specific delivery and assessing genetic variability to advance clinical translation. This system-level analysis positions TnP as a model example for next-generation multi-pathway therapeutics. Full article

Due to its lightweight and superior adsorption properties, carbon foam is frequently employed for the removal of heavy metal pollutants from aqueous solutions. In this study, a novel modified carbon foam (M-CF) was successfully synthesized for the effective removal of Pb²⁺ and Cd²⁺ from water. The synthesis involved partially substituting phenol with the liquefaction product of bamboo powder, followed by modification with a silane coupling agent (KH560) and foaming with n-hexane-loaded activated carbon (H/AC). The prepared carbon foam was comprehensively characterized, and its adsorption performance and mechanism for Pb²⁺ and Cd²⁺ in aqueous solution were investigated. The results showed that M-CF possessed a uniform and well-developed spherical pore structure and demonstrated excellent removal capacity for Cd²⁺ and Pb²⁺. The adsorption process conformed to the Sips isotherm model and the pseudo-second-order kinetic equation, with maximum adsorption capacities of 22.15 mg·g⁻¹ and 61.59 mg·g⁻¹ for Cd²⁺ and Pb²⁺, respectively. Mechanistic analysis revealed that the removal of Cd²⁺ and Pb²⁺ was a result of the synergistic effect of physisorption and chemisorption, accompanied by complexation. Furthermore, precipitates formed during the adsorption process were found to be mainly composed of hydroxides, carbonates, and PbS. This research demonstrates the efficacy of carbon foam prepared from bamboo powder waste as a partial phenol substitute for the efficient removal of Pb²⁺ and Cd²⁺ from water, thus expanding the preparation pathways for novel heavy metal adsorption materials. Full article

Spurred by the enormous therapeutic success of glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP1-RAs) against diabetes and obesity, glucagon family receptor pharmacology has garnered a tremendous amount of interest. Glucagon family receptors, e.g., the glucagon receptor itself (GCGR), the GLP-1R, and the glucose-dependent insulinotropic peptide receptor (GIPR), belong to the incretin receptor superfamily, i.e., receptors that increase blood glucose-dependent insulin secretion. All incretin receptors are class B1 G protein-coupled receptors (GPCRs), coupling to the G_s type of heterotrimeric G proteins which activates adenylyl cyclase (AC) to produce cyclic adenosine monophosphate (cAMP). Most GPCRs undergo desensitization, i.e., uncouple from G proteins and internalize, thanks to interactions with the βarrestins (arrestin-2 and -3). Since the βarrestins can also mediate their own G protein-independent signaling, any given GPCR can theoretically signal (predominantly) either via G proteins or βarrestins, i.e., be a G protein- or βarrestin-“biased” receptor, depending on the bound ligand. A plethora of experimental evidence suggests that the GLP-1R does not undergo desensitization in physiologically relevant tissues in vivo, but rather, it produces robust and prolonged cAMP signals. A particular property of constant cycling between the cell membrane and caveolae/lipid rafts of the GLP-1R may underlie its lack of desensitization. In contrast, GIPR signaling is extensively mediated by βarrestins and the GIPR undergoes significant desensitization, internalization, and downregulation, which may explain why both agonists and antagonists of the GIPR exert the same physiological effects. Here, we discuss this evidence and make a case for the GLP-1R being a phenotypically or functionally G_s-selective receptor. We also discuss the implications of this for the development of GLP-1R poly-ligands, which are increasingly pursued for the treatment of obesity and other diseases. Full article

Electrical connectors play a vital role in ensuring reliable signal transmission in high-frequency microsystems. This study explores the impact of microscale scratch-induced surface roughness on the alternating current (AC) contact impedance of RF coaxial connectors. Unlike traditional approaches that assume idealized surface conditions, controlled micro-defects were introduced at the central contact interface to establish a quantitative relationship between surface morphology and signal degradation. An equivalent circuit model was constructed to account for local impedance variations and the cumulative effects of cascaded connector interfaces. The model was validated using S-parameter measurements obtained from vector network analyzer (VNA) testing, showing strong agreement with simulation results. Experimental results reveal that the low-roughness (0.4 μm) contact surfaces lead to degraded signal integrity due to insufficient micro-contact formation. In contrast, scratch-induced moderate roughness (0.8–4.8 μm) improves transmission performance, although signal quality declines as roughness increases within this range. These effects are further amplified in multi-connector configurations due to accumulated impedance mismatches. This work provides new insight into the coupling between microscale surface features and frequency-domain transmission characteristics, offering practical guidance for surface engineering, contact design, and the development of miniaturized, high-reliability radio frequency interconnects for next-generation communication systems. Full article

With the advancement in the “dual carbon” strategy and the integration of high proportions of renewable energy sources, AC/DC ultra-high-power grids are facing new security challenges such as commutation failure and multi-infeed coupling effects. Fault diagnosis, as an important tool for assisting power grid dispatching, is essential for maintaining the grid’s long-term stable operation. Traditional fault diagnosis methods encounter challenges such as limited samples and data quality issues under complex operating conditions. To overcome these problems, this study proposes a fault sample data enhancement method based on the Wasserstein Generative Adversarial Network with Gradient Penalty (WGAN-GP). Firstly, a simulation model of the AC/DC hybrid system is constructed to obtain the original fault sample data. Then, through the adoption of the Wasserstein distance measure and the gradient penalty strategy, an improved WGAN-GP architecture suitable for feature learning of the AC/DC hybrid system is designed. Finally, by comparing the fault diagnosis performance of different data models, the proposed method achieves up to 100% accuracy on certain fault types and improves the average accuracy by 6.3% compared to SMOTE and vanilla GAN, particularly under limited-sample conditions. These results confirm that the proposed approach can effectively extract fault characteristics from complex fault data. Full article

Stray-current and soft-water leaching can induce severe corrosion in reinforced concrete structures and buried metal pipelines within subway environments. The effects of water-to-binder ratio (W/C), modulus of sodium silicate (Ms), and alkali content (AC) on the mechanical properties of fly-ash-based geopolymer (FAG) at various curing ages were investigated. The influence of curing temperature and high-temperature curing duration on the development of mechanical performance were examined, and the optimal curing regime was determined. Furthermore, based on the mix design of FAG resistant to coupled erosion from stray-current and soft-water, the effects of stray-current intensity and erosion duration on the coupled erosion behavior were analyzed. The results indicated that FAG exhibited slow strength development under ambient conditions. However, thermal curing at 80 °C for 24 h markedly improved early-age strength. The compressive strength of FAG exhibited an increase followed by a decrease with increasing W/B, Ms, and AC, with optimal ranges identified as 0.28–0.34, 1.0–1.6, and 4–7%, respectively. Soft-water alone caused limited leaching, while the presence of stray-current significantly accelerated degradation, with corrosion rates increasing by 4.1 and 7.2 times under 20 V and 40 V, respectively. The coupled corrosion effect was found to weaken over time and with increasing current intensity. Under coupled leaching conditions, compressive strength loss of FAG was primarily influenced by AC, with lesser contributions from W/B and Ms. The optimal mix proportion for corrosion resistance was determined to be W/B of 0.30, Ms of 1.2, and AC of 6%, under which the compressive strength after corrosion achieved the highest value, thereby significantly improving the durability of FAG in harsh environments such as stray-current zones in subways. Full article

Due to the coupling of DC and AC components, the ion flow field of HVDC and HVAC transmission lines in the same corridor or even the same tower is complex and time-dependent. In order to effectively analyze the ground-level electric field of hybrid transmission lines, the Krylov subspace methods with pre-conditioning treatment are used to solve the discretization equations. By optimizing the coefficient matrix, the calculation efficiency of the iterative process of the electric field in the time domain is greatly increased. Based on the limit of electric field, radio interference and audible noise applied in China, the main factor influencing the design of hybrid transmission lines is determined in terms of electromagnetic environment. After the ground-level electric field of transmission lines with different configurations is analyzed, the minimum height and corridor width of double-circuit 500 kV HVAC lines and one-circuit ±800 kV HVDC lines in the same corridor are obtained. The research provides valuable practical recommendations for optimal tower configurations, minimum heights, and corridor widths under various electromagnetic constraints. Full article

Triboelectric nanogenerators (TENGs) hold significant potential for decentralized energy harvesting; however, their dependence on rotational mechanical energy often limits their ability to harness ubiquitous horizontal motion in real-world applications. Here, a single horizontal linear-to-rotational triboelectric nanogenerator (SHLR-TENG) is presented, designed to efficiently convert linear motion into rotational energy using a robust gear system, enabling a high voltage and reliable full cycle of alternating current (AC). The device features a radially patterned disk with triboelectric layers composed of polyimide. The SHLR-TENG achieves a peak-to-peak voltage of 1420 V, a short-circuit current of 117 µA, and an average power output of 41.5 mW, with a surface charge density of 110 µC/m². Moreover, it demonstrates a power density per unit volume of 371.2 W·m⁻³·Hz⁻¹. The device retains 80% efficiency after 1.5 million cycles, demonstrating substantial durability under mechanical stress. These properties enable the SHLR-TENG to directly power commercial LEDs and low-power circuits without the need for energy storage. This study presents an innovative approach to sustainable energy generation by integrating horizontal motion harvesting with rotational energy conversion. The compact and scalable design of the SHLR-TENG, coupled with its resilience to humidity (20–90% RH) and temperature fluctuations (10–70 °C), positions it as a promising next-generation energy source for Internet of Things (IoT) devices and autonomous systems. Full article

We present the numerical proof of a new sensor concept, based on the Resistive AC-Coupled Silicon Detectors (RSDs) paradigm and standard CMOS process, which benefits from having a 100% fill factor and embedded front-end electronics. The compatibility between these two technologies has been investigated, and our encouraging results suggest that this target could be reliably achieved, enabling the possibility to considerably boost the performance of current silicon detectors intended for timing and 4D-tracking. Full article

The decarbonization of residential cooling systems requires innovative solutions to overcome the mismatch between the renewable energy availability and demand. Integrating latent thermal energy storage (LTES) with heat pump/air conditioning (HP/AC) units can help balance energy use and enhance efficiency. However, the dynamic behavior of such integrated systems, particularly under low-load conditions, remains underexplored. This study investigates a 5 kW HP/AC unit coupled with an 18 kWh LTES system using a bio-based Phase Change Material (PCM) with a melting temperature of 9 °C. Two configurations were tested: charging the LTES using either a thermostatic bath or the HP/AC unit. Key parameters such as the stored energy, temperature distribution, and cooling capacity were analyzed. The results show that, under identical conditions (2 °C inlet temperature, 16 L/min flow rate), the energy stored using the HP/AC unit was only 6.3% lower than with the thermostatic bath. Nevertheless, significant cooling capacity fluctuations occurred with the HP/AC unit due to compressor modulation and anti-frost cycles. The compressor frequency varied from 75 Hz to 25 Hz, and inefficient on-off cycling appeared in the final phase, when the power demand dropped below 1 kW. These findings highlight the importance of integrated system design and control strategies. A co-optimized HP/AC–LTES setup is essential to avoid performance degradation and to fully exploit the benefits of thermal storage in residential cooling. Full article

This paper presents a study on the optimization of 2,4-Dichlorophenoxyacetic (2,4-D) acid removal from synthetic wastewater by batch Fenton-Ozonation. The aim of this study is to evaluate the potential of the catalytic system Fe-L27 coupled to ozonation in the presence and absence of H₂O₂ as an effective and affordable technique for the treatment of organic pollutants in water. Fenton-like catalysts for the removal of 2,4-D in aqueous solutions were elaborated using catalysts synthesized by the wet impregnation method. The ACs and prepared catalysts were characterized by nitrogen adsorption–desorption isotherms at 77 K, TGA, XPS, SEM, and TEM. Their efficiency as Fenton-like catalysts was studied. In a first step, a response surface modeling method was employed in order to find the optimal parameters of the Fenton process, and then the optimal O₃/H₂O₂ ratio was established at laboratory scale. Finally, the investigated advanced oxidation processes were carried out at pilot scale. The results show that Fenton-like catalysts obtained by the direct impregnation method enhance the degradation rate and mineralization of 2,4-D. Full article

This study explores the identification, characterization, and biological evaluation of angiotensin I-converting enzyme (ACE)-inhibitory peptides derived from enzymatic hydrolysates of crucian carp swim bladders. Following sequential purification by size-exclusion and reversed-phase chromatography, two bioactive peptides—Hyp-Gly-Ala-Arg (Hyp-GAR) and Gly-Ala-Hyp-Gly-Ala-Arg (GA-Hyp-GAR)—were identified using ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap tandem mass spectrometry. The synthetic peptides demonstrated potent ACE-inhibitory activity in vitro, with IC₅₀ values of 12.2 μM (Hyp-GAR) and 4.00 μM (GA-Hyp-GAR). Molecular docking and enzyme kinetics confirmed competitive inhibition through key interactions with ACE active site residues and zinc coordination. In vivo antihypertensive activity was evaluated in spontaneously hypertensive rats, revealing that GA-Hyp-GAR significantly reduced systolic blood pressure in a dose-dependent manner. At a dose of 36 mg/kg, GA-Hyp-GAR reduced systolic blood pressure by 60 mmHg—an effect comparable in magnitude and timing to that of captopril. Mechanistically, GA-Hyp-GAR modulated levels of angiotensin II, bradykinin, endothelial nitric oxide synthase, and nitric oxide. A 90-day subchronic oral toxicity study in mice indicated no significant hematological, biochemical, or histopathological alterations, supporting the peptide’s safety profile. These findings suggest that GA-Hyp-GAR is a promising natural ACE inhibitor with potential application in functional foods or as a nutraceutical for hypertension management. Full article

Aiming at the problems of serious pavement temperature diseases, low efficiency and high loss of ice-breaking methods, high occupancy rate of waste tires and the low utilization rate and insufficient durability of rubber particles, this paper aims to improve the service level of roads and ensure the safety of winter pavements. A pavement material with high efficiency, low carbon and environmental friendliness for active snow melting and ice breaking is developed. Firstly, NaOH, NaClO and KH550 were used to optimize the treatment of rubber particles. The hydrophilic properties, surface morphology and phase composition of rubber particles before and after optimization were studied, and the optimal treatment method of rubber particles was determined. Then, the optimized rubber particles were used to replace the natural aggregate in the polyurethane gel mixture by the volume substitution method, and the optimum polyurethane gel dosages and molding and curing processes were determined. Finally, the influence law of the road performance of RPGM was compared and analyzed by means of an indoor test, and the ice-breaking effect of RPGM was explored. The results showed that the contact angles of rubber particles treated with three solutions were reduced by 22.5%, 30.2% and 36.7%, respectively. The surface energy was improved, the element types on the surface of rubber particles were reduced and the surface impurities were effectively removed. Among them, the improvement effect of the KH550 solution was the most significant. With the increase in rubber particle content from 0% to 15%, the dynamic stability of the mixture gradually increases, with a maximum increase of 23.5%. The maximum bending strain increases with the increase in its content. The residual stability increases first and then decreases with the increase in rubber particle content, and the increase ranges are 1.4%, 3.3% and 0.5%, respectively. The anti-scattering performance increases with the increase in rubber content, and an excessive amount will lead to an increase in the scattering loss rate, but it can still be maintained below 5%. The fatigue life of polyurethane gel mixtures with 0%, 5%, 10% and 15% rubber particles is 2.9 times, 3.8 times, 4.3 times and 4.0 times higher than that of the AC-13 asphalt mixture, respectively, showing excellent anti-fatigue performance. The friction coefficient of the mixture increases with an increase in the rubber particle content, which can be increased by 22.3% compared with the ordinary asphalt mixture. RPGM shows better de-icing performance than traditional asphalt mixtures, and with an increase in rubber particle content, the ice-breaking ability is effectively improved. When the thickness of the ice layer exceeds 9 mm, the ice-breaking ability of the mixture is significantly weakened. Mainly through the synergistic effect of stress coupling, thermal effect and interface failure, the bonding performance of the ice–pavement interface is weakened under the action of driving load cycle, and the ice layer is loosened, broken and peeled off, achieving efficient de-icing. Full article

This report is on Co and Ti substituted M-type barium and strontium hexagonal ferrites that are reported to be single phase multiferroics due to a transition from Neel type ferrimagnetic order to a spiral spin structure that is accompanied by a ferroelectric polarization in an applied magnetic field. The focus here is the nature of magnetoelectric (ME) interactions in the bilayers of ferroelectric PZT and Co and Ti substituted BaM and SrM. The ME coupling in the ferrite-PZT bilayers arise due to the transfer of magnetostriction-induced mechanical deformation in a magnetic field in the ferrite resulting in an induced electric field in PZT. Polycrystalline Co and Ti doped ferrites, Ba (CoTi)_x Fe_12−2xO_19, (BCTx), and Sr (CoTi)_x Fe_12−2xO₁₉ (SCTx) (x = 0–4) were found to be free of impurity phases for all x-values except for SCTx, which had a small amount of α-Fe₂O₃ in the X-ray diffraction patterns for x ≤ 2.0. The magnetostriction for the ferrites increased with applied filed H to a maximum value of around 2 to 6 ppm for H~5 kOe. BCTx/SCTx samples showed ferromagnetic resonance (FMR) for x = 1.5–2.0, and the estimated anisotropy field was on the order of 5 kOe. The magnetization increased with the amount of Co and Ti doping, and it decreased rapidly with x for x > 1.0. Measurements of ME coupling strengths were conducted on the bilayers of BCTx/SCTx platelets bonded to PZT. The bilayer was subjected to an AC and DC magnetic field H, and the magnetoelectric voltage coefficient (MEVC) was measured as a function of H and frequency of the AC field. For BCTx-PZT, the maximum value of MEVC at low frequency was ~5 mV/cm Oe, and a 40-fold increase at electromechanical resonance (EMR). SCTx–PZT composites also showed a similar behavior with the highest MEVC value of ~14 mV/cm Oe at low frequencies and ~200 mV/cm Oe at EMR. All the bilayers showed ME coupling for zero magnetic bias due to the magnetocrystalline anisotropy field in the ferrite that provided a built-in bias field. Full article