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Review

11 Citations

3,869 Views

35 Pages

Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea

Mehul Patnam,
Sunil R. Dommaraju,
Faisal Masood,
Paula Herbst,
Jin-Hong Chang,
Wen-Yang Hu,
Mark I. Rosenblatt and
Dimitri T. Azar

Cells2023, 12(2), 319;https://doi.org/10.3390/cells12020319

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14 January 2023

Corneal lymphangiogenesis is one component of the neovascularization observed in several inflammatory pathologies of the cornea including dry eye disease and corneal graft rejection. Following injury, corneal (lymph)angiogenic privilege is impaired,...

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Review

603 Views

27 Pages

Limbal Epithelial Stem Cells in Review: Immune and Lymphangiogenic Privilege and Their Clinical Relevance

Berbang Meshko,
Thomas Volatier,
Claus Cursiefen and
Maria Notara

Cells2026, 15(1), 91;https://doi.org/10.3390/cells15010091

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5 January 2026

The cornea maintains transparency by preserving immune and (lymph)angiogenic privilege through active suppression of inflammation and vascular invasion, a process centrally regulated by limbal epithelial stem cells (LESCs) located at the corneosclera...

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Article

2,832 Views

21 Pages

Characterization of Corneal Defects in ATG7-Deficient Mice

Thomas Volatier,
Andreas Mourier,
Johanna Mann,
Berbang Meshko,
Karina Hadrian,
Claus Cursiefen and
Maria Notara

Int. J. Mol. Sci.2025, 26(20), 9989;https://doi.org/10.3390/ijms26209989

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14 October 2025

Regulated proteolysis via autophagy is essential for cellular homeostasis, yet the specific role of autophagy-related gene 7 (ATG7) in corneal epithelial maintenance remains unclear. Using a conditional knockout mouse model (Atg7^f/f K14Cre^+/−),...

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