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54 Results Found

  • Review
  • Open Access
1,127 Views
33 Pages

Ion Channel-Targeting Toxins: Structural Mechanisms of Activation, Inhibition, and Therapeutic Potential

  • Narumi Aoki-Shioi,
  • Shuhei Nomura,
  • Yasuyoshi Tanaka and
  • Shinichi Hirose

2 December 2025

Toxins as channel probes, small guanidinium alkaloids, such as tetrodotoxin and saxitoxin, canonical pore occlusion in voltage-gated Na+ channels. Cystine-rich peptides from spiders, scorpions, cone snails, and sea anemones, which act as pore blocker...

  • Article
  • Open Access
20 Citations
3,953 Views
17 Pages

Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus

  • Xinjia Li,
  • Wanyi Chen,
  • Dongting Zhangsun and
  • Sulan Luo

14 September 2020

The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this p...

  • Review
  • Open Access
1,360 Views
26 Pages

Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms

  • José Otávio Carvalho Sena de Almeida,
  • Simón Gabriel Comerma-Steffensen,
  • José Roberto de Souza de Almeida Leite,
  • Ulf Simonsen and
  • Daniel Dias Rufino Arcanjo

25 September 2025

Background/Objectives: Bioactive peptides derived from animal venoms, toxins, and secretions demonstrate considerable pharmacological potential for use in the management of diabetes mellitus—a highly prevalent metabolic disorder of substantial...

  • Article
  • Open Access
6 Citations
3,580 Views
16 Pages

19 February 2023

One of the main research questions regarding archaeological molluscan purple pigments and dyes is whether it is possible to determine which malacological species produced these colorants. For this determination of the zoological provenance of the pig...

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