- Review
Ion Channel-Targeting Toxins: Structural Mechanisms of Activation, Inhibition, and Therapeutic Potential
- Narumi Aoki-Shioi,
- Shuhei Nomura,
- Yasuyoshi Tanaka and
- Shinichi Hirose
Toxins as channel probes, small guanidinium alkaloids, such as tetrodotoxin and saxitoxin, canonical pore occlusion in voltage-gated Na+ channels. Cystine-rich peptides from spiders, scorpions, cone snails, and sea anemones, which act as pore blocker...