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Special Issue "Role of Myeloid Cells in Viral Infections"
Deadline for manuscript submissions: 29 February 2020.
Interests: macrophages; HIV drug resistance; HIV virology; reservoirs
Interests: macrophages; cell biology; biochemistry
Macrophages are relatively long-lived immune cells that exhibit broad tissue distribution and migration. Their functions are highly diverse and often tissue specific: for example, they are innate immune sentinels, antigen presenters, anti-tumour cells, tissue remodelers, as well as having roles in homeostasis e.g. the placenta, post inflammation resolution.
A number of prokaryotic pathogens are known to parasitize macrophages, including M. Tuberculosis and Leishmanial sp. Even though infection of macrophages has been shown for many viruses, such as dengue, zika, CMV or HIV, viral infection of macrophages is generally less well appreciated and relatively understudied. As an example of the importance of macrophages in HIV disease pathogenesis: it has been documented that some patients experience persistent HIV replication in the brain with clinical consequences. As the primary cell types infected by HIV in brain are myeloid cells such as microglia or perivascular macrophages, macrophages are indeed an important player in HIV infection under such circumstances.
Here we present a range of reviews addressing virus-macrophage interactions and associated implications for disease and therapeutic avenues.
Dr. Ravindra Gupta
Dr. Petra Mlcochova
Manuscript Submission Information
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