Special Issue "Role of Myeloid Cells in Viral Infections"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editors

Dr. Ravindra Gupta
Guest Editor
University of Cambridge, Cambridge, UK
Interests: macrophages; HIV drug resistance; HIV virology; reservoirs
Dr. Petra Mlcochova
Guest Editor
University of Cambridge, Cambridge, UK
Interests: macrophages; cell biology; biochemistry

Special Issue Information

Dear Colleagues,

Macrophages are relatively long-lived immune cells that exhibit broad tissue distribution and migration. Their functions are highly diverse and often tissue specific: for example, they are innate immune sentinels, antigen presenters, anti-tumour cells, tissue remodelers, as well as having roles in homeostasis e.g. the placenta, post inflammation resolution.

A number of prokaryotic pathogens are known to parasitize macrophages, including M. Tuberculosis and Leishmanial sp. Even though infection of macrophages has been shown for many viruses, such as dengue, zika, CMV or HIV, viral infection of macrophages is generally less well appreciated and relatively understudied. As an example of the importance of macrophages in HIV disease pathogenesis: it has been documented that some patients experience persistent HIV replication in the brain with clinical consequences. As the primary cell types infected by HIV in brain are myeloid cells such as microglia or perivascular macrophages, macrophages are indeed an important player in HIV infection under such circumstances.

Here we present a range of reviews addressing virus-macrophage interactions and associated implications for disease and therapeutic avenues.

Dr. Ravindra Gupta
Dr. Petra Mlcochova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • macrophage
  • reservoir
  • SAMHD1
  • virus
  • HIV
  • replication
  • persistence

Published Papers

This special issue is now open for submission.
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