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Diverse and Unexpected Roles of Human Monocytes/Macrophages in the Immune Response to Influenza Virus

1
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
2
Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Viruses 2020, 12(4), 379; https://doi.org/10.3390/v12040379
Received: 14 February 2020 / Revised: 23 March 2020 / Accepted: 27 March 2020 / Published: 31 March 2020
(This article belongs to the Special Issue Role of Myeloid Cells in Viral Infections)
Human monocytes/macrophages play a central role in the immune response and defense of the host from influenza virus infection. They classically act as antigen-presenting cells for lymphocytes in the context of an immune cell cluster. In that setting, however, monocytes/macrophages exhibit additional, unexpected, roles. They are required for influenza virus infection of the lymphocytes in the cluster, and they are responsible for lymphocyte apoptosis via their synthesis and expression of the viral neuraminidase. Surprisingly, human alveolar macrophages, expected to be among the first cells to encounter the virus, are not susceptible to direct infection by a human influenza virus but can be infected when the virus is complexed with an antibody. Such monocyte/macrophage responses to influenza virus challenge should be considered part of a very complex but quite effective defense, since the common outcome is recovery of the host with development of immunity to the challenging strain of virus. View Full-Text
Keywords: influenza virus; human monocytes; human macrophages; human lymphocytes; immune cell clusters; alveolar macrophages; lymphocyte activation; lymphocyte apoptosis influenza virus; human monocytes; human macrophages; human lymphocytes; immune cell clusters; alveolar macrophages; lymphocyte activation; lymphocyte apoptosis
MDPI and ACS Style

Roberts, N.J., Jr. Diverse and Unexpected Roles of Human Monocytes/Macrophages in the Immune Response to Influenza Virus. Viruses 2020, 12, 379.

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