Molecular Insights into Zoonotic and Animal Pathogens: A One Health Perspective

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1486

Editors


E-Mail Website
Guest Editor
Schreiber School of Veterinary Medicine, Rowan University, Glassboro, NJ 08028, USA
Interests: immunology; clinical microbiology; molecular biology; bioinformatics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Interests: systems approach to antimicrobial resistance; antibiotic alternatives; antimicrobial stewardship; liver abscesses in feedlot cattle; bovine respiratory disease (BRD) in cattle
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The One Health approach recognizes the intricate and dynamic connections among animal, human, and environmental health that are critical in addressing infectious diseases. Our Special Issue seeks to gather contributions that delve into the molecular mechanisms underlying pathogen evolution, virulence, antimicrobial resistance, and cross-species transmission, with an emphasis on research that elucidates the complex interplay at the animal–human–ecosystem interface.

We welcome original research articles, short communications, and comprehensive reviews that employ molecular, genomic, proteomic, or bioinformatic approaches to investigate pathogens affecting domestic, companion, livestock, and wildlife species. Suitable submissions may explore diverse topics, including but not limited to pathogen diversity and evolution, host–pathogen interactions, molecular epidemiology, the development of innovative diagnostics and vaccines, and the identification and characterization of environmental reservoirs of infection.

This Special Issue aims to highlight interdisciplinary advances that bridge the gap between veterinary and human health disciplines. By showcasing cutting-edge research, we seek to strengthen the scientific foundation for One Health initiatives and enhance our collective capacity to detect, monitor, and mitigate infectious threats at the intersection of animal, human, and environmental health.

We invite you to contribute your latest findings and join us in advancing a deeper, molecular-level understanding of zoonotic and animal pathogens within the One Health framework.

Dr. Mohamed Abouelkhair
Dr. Raghavendra Amachawadi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • One Health
  • zoonotic pathogens
  • molecular epidemiology
  • companion animal health
  • wildlife pathogens
  • domestic animals
  • antimicrobial resistance
  • host–pathogen interactions
  • genomics
  • proteomics
  • metagenomics
  • metabolomics
  • virulence factors
  • cross-species transmission
  • molecular diagnostics
  • veterinary microbiology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 12230 KB  
Article
Molecular Characterization and Comparative Genomics of Two Staphylococcus pseudintermedius Strains from Humans in Egypt
by Ola K. Elsakhawy, Haitham Elaadli, Yassien Badr, May Raouf, Stephen A. Kania, Hend Altaib and Mohamed A. Abouelkhair
Vet. Sci. 2026, 13(5), 424; https://doi.org/10.3390/vetsci13050424 - 27 Apr 2026
Viewed by 1125
Abstract
Staphylococcus pseudintermedius is an opportunistic bacterium previously associated with dogs but has recently been found in human infections, raising zoonotic concerns. Genomic characterization of human S. pseudintermedius isolates can provide preliminary information on antibiotic resistance, pathogenicity, and genomic features relevant to host range. [...] Read more.
Staphylococcus pseudintermedius is an opportunistic bacterium previously associated with dogs but has recently been found in human infections, raising zoonotic concerns. Genomic characterization of human S. pseudintermedius isolates can provide preliminary information on antibiotic resistance, pathogenicity, and genomic features relevant to host range. Two S. pseudintermedius isolates (hereafter referred to as S. pseudintermedius EGH1 and S. pseudintermedius EGH2) from human clinical samples in Egypt were sequenced using the Illumina NovaSeq X Plus platform. To assess genetic relatedness to human S. pseudintermedius isolates worldwide, multilocus sequence typing (MLST), pangenome analysis, and antimicrobial resistance gene profiling were performed. The sequencing produced a total of 9,499,989 reads for S. pseudintermedius EGH1 and 9,567,531 reads for S. pseudintermedius EGH2. Sequences were assembled with Geneious Prime® 2025 and annotated using NCBI Prokaryotic Genome Annotation Pipeline v6.10. Pangenome analysis identified 9574 genes, comprising 1681 core genes (17.56%), 180 soft-core genes (1.88%), 837 shell genes (8.74%), and 6876 cloud genes (71.82%). MLST was conducted on human S. pseudintermedius genome assemblies using MLST v2.23.0. The analysis revealed both isolates as novel sequence types: S. pseudintermedius EGH1 was assigned ST-3037 with a new allele (purA-107), and S. pseudintermedius EGH2 was assigned ST-2874. Clonal relationships among S. pseudintermedius isolates were evaluated using the eBURST algorithm. This study presents the first next-generation genome sequencing and comparative genomic analysis of S. pseudintermedius isolates from humans in Egypt. Future studies integrating genomic, epidemiological, and phenotypic data are required. Full article
Show Figures

Figure 1

Back to TopTop