Special Issue "Immunogenic Effects of Electroporation-Based Treatments"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 9616
Special Issue Editors
Interests: oncoimmunology; gene electrotransfer; DNA immunization; electroporation; plasmid DNA; electrochemotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: translational research of electroporation based technology; predominantly electroporation-based gene transfer and drug delivery; cancers; melanoma
Special Issues, Collections and Topics in MDPI journals
Interests: gene electrotransfer; DNA immunization; electroporation
Interests: gene therapy; pattern recognition; electroporation
Interests: DNA vaccines; gene electrotransfer; tumor immunology; drug delivery; device and protocol development; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Studies in the field of immunology are revealing an attractive set of novel and different therapeutic approaches to treat cancer and infectious diseases. Electroporation, also named electropermeabilization (EP), is an efficient and safe technique based on the application of voltage pulses of sufficient strength and duration to generate transient membrane permeabilization/poration, thus allowing the delivery of drugs or genetic material into the target cells via electrotransfer. Past and recent results underline the capability of EP to influence the immune system response: following EP treatments, different innate and adaptive immune cells can be recruited, influencing immune responses at local and distant levels. Due to this property, many studies in the field of immunization by electroporation have been undertaken.
Intramuscular and skin gene electrotransfer (GET) represents a minimal invasive strategy to employ in immunotherapy and/or vaccination against infectious and cancer diseases, and to treat wound healing. Electrochemotherapy (ECT), irreversible electroporation (IRE), nano-pulse stimulation (NPS) and calcium electroporation (CaEP) are becoming more widely used in clinical protocols to treat different kinds of cancer with positive outcomes. Employment of nucleic acids for the development of new vaccines to deliver via electroporation is emerging as a new platform at the front line of the pandemic.
The aim of this Special Issue is to revive the success of a previous one, by pointing out the advancements in the field and eliciting a debate. Induction of immunological effects and enhancement of the immune system response induced by genetic vaccines and/or immunomodulatory molecules, administered alone or in combination with other therapeutic treatments by EP, will be discussed. Presentations of results on the immunological effects of drugs delivered by electric fields in pre-clinical and clinical trials will be very welcome as well.
The peer-reviewed papers (research articles or reviews) will provide a cross-section on the ongoing research in the field of electroporation applied to cancer and infectious diseases.
Prof. Emanuela Signori
Prof. Maja Čemažar
Prof. Mariangela De Robertis
Prof. Loreé C. Heller
Prof. Richard Heller
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- electroporation
- vaccines
- oncoimmunology