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Review

Clinical Applications and Immunological Aspects of Electroporation-Based Therapies

1
Viral Vector Laboratory, Cancer Institute of São Paulo, University of São Paulo, São Paulo 01246-000, Brazil
2
Laboratory of Experimental Oncology, Cancer Institute of São Paulo, University of São Paulo, São Paulo 01246-000, Brazil
3
Institute of Translational Pharmacology, CNR, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Ralph A. Tripp
Vaccines 2021, 9(7), 727; https://doi.org/10.3390/vaccines9070727
Received: 29 April 2021 / Revised: 14 June 2021 / Accepted: 21 June 2021 / Published: 2 July 2021
(This article belongs to the Special Issue Immunogenic Effects of Electroporation-Based Treatments)
Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunological aspects involved in electrochemotherapy and gene electrotransfer, two important EP-based cancer therapies in human and veterinary oncology. View Full-Text
Keywords: bleomycin; electrochemotherapy; electroporation; gene electrotransfer; vaccines bleomycin; electrochemotherapy; electroporation; gene electrotransfer; vaccines
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MDPI and ACS Style

Luz, J.C.d.S.d.; Antunes, F.; Clavijo-Salomon, M.A.; Signori, E.; Tessarollo, N.G.; Strauss, B.E. Clinical Applications and Immunological Aspects of Electroporation-Based Therapies. Vaccines 2021, 9, 727. https://doi.org/10.3390/vaccines9070727

AMA Style

Luz JCdSd, Antunes F, Clavijo-Salomon MA, Signori E, Tessarollo NG, Strauss BE. Clinical Applications and Immunological Aspects of Electroporation-Based Therapies. Vaccines. 2021; 9(7):727. https://doi.org/10.3390/vaccines9070727

Chicago/Turabian Style

Luz, Jean C.d.S.d., Fernanda Antunes, Maria A. Clavijo-Salomon, Emanuela Signori, Nayara G. Tessarollo, and Bryan E. Strauss 2021. "Clinical Applications and Immunological Aspects of Electroporation-Based Therapies" Vaccines 9, no. 7: 727. https://doi.org/10.3390/vaccines9070727

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