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Special Issue "Molecular Mechanisms of Human Persistent Enterovirus Infections"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (28 May 2022) | Viewed by 3841
Special Issue Editor
Interests: enterovirus; positive single-strand RNA; persistence; molecular mechanisms; virus-cell interaction; inflammation; immunity; escape to immune system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Human enteroviruses (EVs) belong to the Picornaviridae family, a highly diverse group of small, non-enveloped, icosahedral-shaped viruses with single positive-strand RNA genomes. EV species (A to D) are recognized as major causes of human diseases, particularly in neonates and young children where infections can range from acute, self-limited febrile illness to meningitis, myocarditis, hepatitis, and acute flaccid myelitis. As other RNA viruses, EVs have been shown to develop persistent infections of some target tissues resulting in chronic diseases such as myositis, type 1 diabetes, chronic myocarditis and dilated cardiomyopathy. Emergence and maintenance of persistent EV RNA forms during acute infection depend on early host–virus interactions mechanisms and to the virus ability to develop strategies to escape host immune responses. The combination of low-level replication and translation activities of persistent viruses, associated with the capacity of these RNA forms to early modulate inflammatory mechanisms such as type-I IFN response activation pathway, could explain how EVs can establish a persistent infection in human target cells. The present review proposes to dissect cellular and viral molecular mechanisms underlying establishment and maintenance of persistent EV infections. Taken together, our contribution to this special issue is expected to stimulate research and development of further preventive or curative strategies to fight against persistent EV infections driving the development of severe human chronic diseases.
Dr. Laurent Andreoletti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- positive single-strand RNA
- molecular mechanisms
- virus-cell interaction
- escape to immune system