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Vaccines
Special Issues
Rational Vaccine Design against Malaria
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Rational Vaccine Design against Malaria

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Infectious Diseases".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 1754

Special Issue Editors

Dr. Hirdesh Kumar

E-Mail Website
Guest Editor
National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA
Interests: malaria; vaccine; attenuated parasites; antigens; infectious diseases; structural vaccinology
Dr. Peeyush Ranjan

E-Mail Website
Guest Editor
Department of Cell Biology & Molecular Genetics, University of Maryland, College Park, MD 20742, USA
Interests: therapeutic proteins; vaccine targets; infectious diseases
Dr. Vinay Kumar

E-Mail Website
Guest Editor
Max-Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Interests: RNA-based therapeutics; infectious diseases; structural biology
Dr. Sarita Puri Mishra

E-Mail Website
Guest Editor
Department of Bioscience, University of Milan, 20122 Milano, Italy
Interests: therapeutic proteins; protein biochemistry

Special Issue Information

Dear Colleagues,

Malaria remains one of the most devastating and life-threatening diseases worldwide that causes more than half a million deaths annually. The currently available malaria vaccine, RTS,S/AS01, can prevent malaria in young African children noting a 30% reduction in deadly severe anemia. However, higher vaccine efficacy is much needed. Therefore, it is necessary to identify potential vaccine candidates to elicit more robust protective responses against malaria. In light of malaria parasites' available genomic, proteomic, and metabolomic information, it is the most promising time to switch from traditional empirical approaches to advanced, rational designs, and to identify potent malaria vaccine candidates.

We are pleased to invite you to submit your manuscript related to novel strategies for malaria vaccine design. We welcome original research articles describing novel malaria vaccine candidates based on (but not limited to) parasite-focused and reverse vaccinology, structural vaccinology, and/or immunoinformatics.

Dr. Hirdesh Kumar
Dr. Peeyush Ranjan
Dr. Vinay Kumar
Dr. Sarita Puri Mishra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malaria
  • vaccine
  • Plasmodium
  • attenuated parasites
  • antigens
  • adjuvants
  • vaccine design
  • subunit vaccine
  • vaccine efficacy
  • vaccine design

Published Papers (1 paper)

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Research

13 pages, 1773 KiB  
Article
Differential Homing Receptor Profiles of Lymphocytes Induced by Attenuated versus Live Plasmodium falciparum Sporozoites
by Marie Mura, Tanmaya Atre, Tatyana Savransky and Elke S. Bergmann-Leitner
Vaccines 2022, 10(10), 1768; https://doi.org/10.3390/vaccines10101768 - 21 Oct 2022
Cited by 1 | Viewed by 1359
Abstract
The onset of an adaptive immune response provides the signals required for differentiation of antigen-specific lymphocytes into effector cells and imprinting of these cells for re-circulation to the most appropriate anatomical site (i.e., homing). Lymphocyte homing is governed by the expression of tissue-specific [...] Read more.
The onset of an adaptive immune response provides the signals required for differentiation of antigen-specific lymphocytes into effector cells and imprinting of these cells for re-circulation to the most appropriate anatomical site (i.e., homing). Lymphocyte homing is governed by the expression of tissue-specific lymphocyte homing receptors that bind to unique tissue-specific ligands on endothelial cells. In this study, a whole-parasite malaria vaccine (radiation-attenuated sporozoites (RAS)) was used as a model system to establish homing receptor signatures induced by the parasite delivered through mosquito bite to provide a benchmark of desirable homing receptors for malaria vaccine developers. This immunization regimen resulted in the priming of antigen-specific B cells and CD8+ T cells for homing primarily to the skin and T/B cell compartments of secondary lymphoid organs. Infection with live sporozoites, however, triggers the upregulation of homing receptor for the liver and the skin, demonstrating that there is a difference in the signal provided by attenuated vs. live sporozoites. This is the first report on imprinting of homing routes by Plasmodium sporozoites and, surprisingly, it also points to additional, yet to be identified, signals provided by live parasites that prime lymphocytes for homing to the liver. The data also demonstrate the utility of this method for assessing the potential of vaccine formulations to direct antigen-specific lymphocytes to the most relevant anatomical site, thus potentially impacting vaccine efficacy. Full article
(This article belongs to the Special Issue Rational Vaccine Design against Malaria)
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