Immunity at the Gate of Entrance; Vaccines against Respiratory Viruses such as Influenza and RSV
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Influenza Virus Vaccines".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 4489
Special Issue Editor
Interests: influenza; resident t-cells; universal vaccines; animal models; pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Most vaccines induce systemic immunity through intramuscular administration. This route of vaccination disregards a very potent part of the immune system—local adaptive immunity. There are numerous reports that show that mucosal antibodies (IgA), resident memory T-cells (Trm), and memory B-cells in mucosal associated lymphoid tissue play an important role in protection against respiratory viruses at the gate of entrance. Despite this, a limited amount of locally administered respiratory vaccines are available.
Challenges include adjuvation, formulation, and induction of long-lasting immunity. For influenza in particular, a broadly reactive immunity is a challenge, and Trm and local stem antibodies may be an answer. For both RSV and influenza immunity, longevity is a holy grail. Therefore, research that provides insight into local immune parameters that correlate with protection against respiratory viruses or that are shown to be long-lasting is welcomed. Immune induction may be through vaccination, using adjuvants and formulation techniques to steer the immune response or by immune transfer techniques, etc. when this leads to a better understanding of potent vaccine targets.
Combining insights and strategies developed for different respiratory viruses into one Special Issue encourages cross-pollination of the different research fields and would advance the development of locally administered respiratory vaccines on the whole.
Dr. Jorgen De Jonge
Guest Editor
Manuscript Submission Information
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Keywords
- mucosal immunity
- resident T-cells
- influenza
- RSV
- universal
- vaccines
- protection
- respiratory viruses
