Mucosal Immunity and Vaccine

Dear Colleagues,

Mucosal surfaces are the first line of defense against numerous infectious agents, yet the development of vaccines targeting these sites has historically been challenging. This Special Issue will address the latest advancements and challenges in inducing robust mucosal immune responses through vaccination, with implications for preventing infections such as respiratory, gastrointestinal, and sexually transmitted diseases.

This Special Issue will focus on the critical role of mucosal immunity in vaccine development, exploring how vaccines can be designed to elicit effective immune responses at mucosal surfaces—the primary entry points for many pathogens. In this Special Issue, original research articles, reviews, short communications, and perspectives are welcome.

Topic areas may include (but are not limited to) the following:

• Mechanisms of mucosal immune responses to vaccines.
• Development of mucosal vaccines: oral, nasal, and other routes of administration.
• Comparative efficacy of mucosal versus systemic immunity in infection control.
• Mucosal adjuvants and delivery systems for enhancing vaccine efficacy.
• Role of secretory IgA and other mucosal antibodies in vaccine-induced protection.
• Immune memory and long-term protection conferred by mucosal vaccines.
• Case studies on mucosal vaccines in clinical trials (e.g., for influenza, rotavirus, and HIV).
• Challenges in developing mucosal vaccines for emerging pathogens.
• Computational modeling and bioinformatics in mucosal vaccine design.

We look forward to receiving your contributions.

Dr. Xingmin Sun
Dr. Yongqun He (Oliver)
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.