Advances in Streptococcus pneumoniae Research: Host–Pathogen Interactions and Vaccine Development
A Special Issue of Vaccines (ISSN 2076-393X) belonging to the section "Pathogens-Host Immune Boundaries".
Deadline for manuscript submissions: 27 March 2027 | Viewed by 837
Editors
Interests: microbiology; molecualr biology; S. pneumonia; antimicrobila resistant; quorum sensing
Interests: microbiology; molecualr biology; COVID; vaccine targets
Special Issue Information
Dear Colleagues,
Streptococcus pneumoniae remains one of the leading causes of pneumonia, meningitis, sepsis, and otitis media worldwide. It particularly affects young children, older adults, and immunocompromised individuals. Despite the substantial success of pneumococcal conjugate vaccines in reducing disease burden, challenges such as serotype replacement, vaccine escape, and the emergence of non-vaccine strains continue to threaten global public health. A deeper understanding of host–pathogen interactions is essential for elucidating the molecular mechanisms underlying pneumococcal colonization, immune evasion, invasion, and disease progression. Recent advances in immunology, molecular microbiology, genomics, proteomics, and systems biology have provided new insights into the complex interplay between S. pneumoniae and the host immune system. Simultaneously, these discoveries are driving the development of innovative vaccine strategies, including protein-based, serotype-independent, and universal pneumococcal vaccines.
This Special Issue aims to highlight recent advances in pneumococcal pathogenesis, host immune responses, virulence mechanisms, vaccine research, and translational approaches that contribute to the prevention and control of pneumococcal diseases.
Dr. James John
Dr. Krupakar Parthasarathy
Dr. Saqib Hassan
Guest Editors
Manuscript Submission Information
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Keywords
- host immunity
- bacterial colonization
- immune evasion
- virulence mechanisms
- protein-based vaccines
- pneumococcal disease
- translational vaccine research
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