Oral and Nucleic Acid Vaccines for Zoonotic and Animal Infectious Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 578

Special Issue Editor


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Guest Editor
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
Interests: zoonotic diseases; vaccine development; immunological mechanism

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the latest developments in oral and nucleic acid vaccines for the prevention and control of zoonotic and animal infectious diseases. It will encompass a range of topics, including vaccine design and process development, safety and efficacy evaluation, scale production and manufacturing process optimization, and the elucidation of the immunological mechanisms in various animal targets. The Issue aims to highlight the importance of these vaccines in reducing the infection and transmission of diseases between animals and humans, thereby improving public health and animal welfare. By featuring cutting-edge research, the Special Issue will provide a platform for scientists and health professionals to share knowledge and foster collaboration in the field of vaccine science.

Dr. Lei Shuai
Guest Editor

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Keywords

  • oral vaccines
  • nucleic acid vaccines
  • zoonotic diseases
  • animal infectious diseases
  • vaccine development
  • vaccine safety
  • vaccine efficacy
  • immunological mechanism

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Published Papers (1 paper)

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Research

15 pages, 5946 KiB  
Article
Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs
by Hong Huo, Han Wang, Shulin Liang, Zilong Wang, Jinming Wang, Qingzhu Wang, Chan Li, Yuting Tao, Jinying Ge, Zhiyuan Wen, Jinliang Wang, Weiye Chen, Xijun Wang, Lei Shuai and Zhigao Bu
Vaccines 2025, 13(6), 614; https://doi.org/10.3390/vaccines13060614 - 6 Jun 2025
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Abstract
Background: canine distemper (CD) is a highly contagious and fatal disease caused by canine distemper virus (CDV), posing a significant threat to carnivores. New CDV strain circulation and multi-species infection may lead to the potential dilemma of safety concern and insufficient efficacy of [...] Read more.
Background: canine distemper (CD) is a highly contagious and fatal disease caused by canine distemper virus (CDV), posing a significant threat to carnivores. New CDV strain circulation and multi-species infection may lead to the potential dilemma of safety concern and insufficient efficacy of the commercial modified live vaccines. Safe and effective vaccines for canine and wildlife prevention of CD need to be continuously updated and developed. Methods: we developed two DNA vaccines, p17F-LNP and p17H-LNP, encoding the fusion protein (F) or hemagglutinin protein (H) of a field CDV strain (HLJ17) and encapsulated in lipid nanoparticles (LNPs). Serum neutralizing antibody (NAb) was evaluated via neutralization tests, and mouse serum cytokine detection were evaluated via ELISA. Results: immunization of p17F-LNP and p17H-LNP monovalent or bivalent were safe, and induced robust CDV NAb and cytokine responses in mice. LNP encapsulation improved immune responses compared to naked DNA formulation, and the bivalent formulation of p17F-LNP and p17H-LNP (p17F/H-LNP) exhibited synergistic effects with a high level of immune responses. Moreover, two doses of p17F/H-LNP induced long-lasting CDV NAb for over 300 days in dogs, and prime and boost NAb responses in foxes and raccoon dogs. Conclusions: the preliminary findings provided here warrant further development of the p17F/H-LNP vaccine for animal targets against CDV infection. Full article
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