The Immunotherapy Against Swine Disease

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 331

Special Issue Editors


E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: porcine epidemic diarrhea virus; other swine infectious viruses

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: porcine reproductive and respiratory syndrome virus; other swine infectious viruses; live vector vaccine

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: porcine reproductive and respiratory syndrome virus; other swine infectious viruses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue, entitled "The Immunotherapy Against Swine Disease", aims to explore recent advancements in immunotherapeutic strategies targeting viral and bacterial diseases that significantly affect both the swine industry and overall animal health. Emphasizing the importance of innovative approaches, we invite studies focused on vaccine development, monoclonal antibodies, and host immune modulation as essential components in enhancing swine health outcomes. This Special Issue serves as a platform for researchers to present their findings, examine emerging technologies, and address the challenges inherent in implementing immunotherapy within swine populations. We encourage submissions that encompass both basic and applied research, particularly those investigating immunological responses, the efficacy of various therapeutic modalities, and comparative analyses. Through this initiative, our goal is to stimulate collaboration and deepen our understanding of effective immunotherapeutic interventions in the swine industry.

We look forward to receiving your contributions.

Prof. Dr. Changlong Liu
Prof. Dr. Fei Gao
Prof. Dr. Yanhua Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunotherapy
  • swine infectious diseases
  • vaccines
  • monoclonal antibodies
  • immune modulation
  • viral infections

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

25 pages, 3983 KB  
Article
Expression and Immunological Characterization of African Swine Fever Virus EP153R Protein for Serodiagnosis and Its Delivery via a Recombinant PRRSV Live Vector
by Meng Luo, Wenna Shuai, Ziqiang Guo, Jiale Li, Liwei Li, Yanjun Zhou, Yifeng Jiang, Wu Tong, Yifan Zeng, Jinbin Wang, Li Zhao and Fei Gao
Vaccines 2025, 13(11), 1110; https://doi.org/10.3390/vaccines13111110 - 29 Oct 2025
Abstract
Background/Objectives: African Swine Fever (ASF), caused by the African Swine Fever Virus (ASFV), is a highly contagious and lethal disease in pigs, for which no recognized safe and effective vaccine is currently available. The ASFV EP153R gene, expressed during both early and late [...] Read more.
Background/Objectives: African Swine Fever (ASF), caused by the African Swine Fever Virus (ASFV), is a highly contagious and lethal disease in pigs, for which no recognized safe and effective vaccine is currently available. The ASFV EP153R gene, expressed during both early and late infection stages, exhibits strong protective potential. Utilizing advances in genetic engineering, recombinant PRRSV vector vaccines carrying ASFV exogenous genes were constructed. This study aims to prepare pEP153R-based polyclonal antibodies and an iELISA detection method using the constructed rPRRSV-EP153R as a specific target to verify the iELISA’s specificity and effectiveness. Methods: A prokaryotic plasmid, pCold-TF-EP153R, was constructed to express protein in BL21 (DE3). The purified soluble protein (2 mg/mL) was used to generate a murine polyclonal antibody and establish an indirect ELISA. The EP153R gene was inserted between ORF1b and ORF2a of PRRSV via reverse genetics, yielding recombinant rPRRSV-EP153R. Its biological properties were assessed in vitro and in vivo. Results: The pEP153R was specifically detected by both anti-His antibody and generated polyclonal antibodies. An established iELISA showed high specificity, sensitivity, and 98.18% accuracy. The antibodies specifically recognized pEP153R expressed in recombinant virus and eukaryotic systems. Additionally, the recombinant virus stably maintained EP153R without changes in virological characteristics relative to vHuN4-F112. In vaccinated piglets, the rPRRSV-EP153R induced a specific, consistent, and detectable immune response. Conclusions: The established iELISA, characterized by high specificity, sensitivity, and accuracy, furnishes reliable technical support for the serological diagnosis of ASFV. Meanwhile, the recombinant virus rPRRSV-EP153R demonstrates potential as a novel live vectored vaccine candidate, with the capability to induce specific immunity against both ASFV and PRRSV. Full article
(This article belongs to the Special Issue The Immunotherapy Against Swine Disease)
Show Figures

Figure 1

Back to TopTop