Vaccines Against Enteric Bacterial Pathogens in Poultry

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2484

Special Issue Editors


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Guest Editor
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
Interests: vaccine development; avian immunology; antibiotic alternatives; probiotics as feed additives; immunomodulators; poultry health; poultry products safety
Special Issues, Collections and Topics in MDPI journals
Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
Interests: poultry diseases; avian Immunology; vaccine development

Special Issue Information

Dear Colleagues,

As the poultry industry transitions into the "no antibiotic era," it becomes critically imperative to advance the development of vaccines able to target emerging bacterial diseases that pose a significant economic threat to the poultry industry, with necrotic enteritis caused by Clostridium perfringens being a notable example. Additionally, there is a need to control foodborne bacterial pathogens that pose threats to public health, such as Salmonella spp., Campylobacter spp., Escherichia. coli, and Listeria monocytogenes.

This Special Issue is dedicated to showcasing recent scientific and technical advancements in vaccines that are designed to combat enteric bacterial pathogens in poultry. We extend an invitation for contributions in the form of original research or review articles, focusing on innovative vaccination strategies. This includes exploring the use of recombinant technology and nanotechnology in vaccine development and delivery, as well as investigating new immunomodulators and adjuvants like Toll-like receptor ligands, cytokines, nanoparticles, probiotics, and other novel agents to enhance vaccine immunogenicity and protective efficacy against the aforementioned bacterial pathogens.

Dr. Khaled Abdelaziz
Dr. Ahmed Ali
Guest Editors

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Keywords

  • vaccine
  • immunomodulators
  • adjuvants
  • chicken
  • poultry
  • bacteria
  • necrotic enteritis
  • Clostridium perfringens
  • Salmonella
  • Campylobacter
  • E. coli
  • Listeria

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Published Papers (1 paper)

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Research

19 pages, 3925 KiB  
Article
Comparative Effectiveness of Various Multi-Antigen Vaccines in Controlling Campylobacter jejuni in Broiler Chickens
by Mostafa Naguib, Shreeya Sharma, Abigail Schneider, Sarah Wehmueller and Khaled Abdelaziz
Vaccines 2024, 12(8), 908; https://doi.org/10.3390/vaccines12080908 - 10 Aug 2024
Cited by 1 | Viewed by 1477
Abstract
This study was undertaken to evaluate and compare the efficacy of different multi-antigen vaccines, including heat-inactivated, whole lysate, and subunit (outer membrane proteins [OMPs]) C. jejuni vaccines along with the immunostimulant CpG ODN in controlling Campylobacter colonization in chickens. In the first trial, [...] Read more.
This study was undertaken to evaluate and compare the efficacy of different multi-antigen vaccines, including heat-inactivated, whole lysate, and subunit (outer membrane proteins [OMPs]) C. jejuni vaccines along with the immunostimulant CpG ODN in controlling Campylobacter colonization in chickens. In the first trial, 125 μg of C. jejuni OMPs and 50 μg of CpG ODN were administered individually or in combination, either in ovo to chick embryos or subcutaneously (SC) to one-day-old chicks. In the second trial, different concentrations of C. jejuni antigens (heat-killed, whole lysate, and OMPs) were administered SC to one-day-old chicks. The results of the first trial revealed that SC immunization with the combination of CpG ODN and C. jejuni OMPs elevated interferon (IFN)-γ, interleukin (IL)-1β, and IL-13 gene expression in the spleen, significantly increased serum IgM and IgY antibody levels, and reduced cecal C. jejuni counts by approximately 1.2 log10. In contrast, in ovo immunization did not elicit immune responses or confer protection against Campylobacter. The results of the second trial showed that SC immunization with C. jejuni whole lysate or 200 μg OMPs reduced C. jejuni counts by approximately 1.4 and 1.1 log10, respectively. In conclusion, C. jejuni lysate and OMPs are promising vaccine antigens for reducing Campylobacter colonization in chickens. Full article
(This article belongs to the Special Issue Vaccines Against Enteric Bacterial Pathogens in Poultry)
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