Advances in Immunotherapy for T Cells and Tumors

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cellular/Molecular Immunology".

Deadline for manuscript submissions: closed (15 March 2025) | Viewed by 1648

Special Issue Editor


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Guest Editor
UT Southwest Medical Center, Dallas, TX, USA
Interests: cancer Immunotherapy; nanomedicine; virus infection

Special Issue Information

Dear Colleagues,

Cancer is a devastating disease which has been and continues to be one of the main threats to human health. Traditional cancer treatments, including surgery, chemotherapy, and radiation therapy, have demonstrated very limited efficacy for patients with late-stage disease. In addition, chemotherapy and radiotherapy often cause considerable side effects. Therefore, innovative and effective cancer treatments are urgently needed for cancer patients with late-stage and refractory disease. Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies.

This Special Issue welcomes reviews, as well as original articles related to research on a broad range of immunotherapy treatments, including cellular therapies, vaccines, and ICB; the identification of new predictive biomarkers and therapeutic targets; novel therapeutic approaches; and the use of immune modulators to overcome immune resistance, among others.

Dr. Zhichen Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer immunotherapy
  • immunotherapy
  • tumors
  • T cell
  • vaccines
  • immune resistance

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Published Papers (1 paper)

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Review

36 pages, 2117 KiB  
Review
HDAC3: A Multifaceted Modulator in Immunotherapy Sensitization
by Rui Han, Yujun Luo, Jingdong Gao, Huiling Zhou, Yuqian Wang, Jiaojiao Chen, Guoyin Zheng and Changquan Ling
Vaccines 2025, 13(2), 182; https://doi.org/10.3390/vaccines13020182 - 13 Feb 2025
Viewed by 1241
Abstract
Histone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it as a promising target for enhancing cancer immunotherapy. This work comprehensively explores HDAC3’s multifaceted roles, focusing on its regulation of key immune-modulatory pathways such [...] Read more.
Histone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it as a promising target for enhancing cancer immunotherapy. This work comprehensively explores HDAC3’s multifaceted roles, focusing on its regulation of key immune-modulatory pathways such as cGAS-STING, ferroptosis, and the Nrf2/HO-1 axis. These pathways are central to tumor immune evasion, antigen presentation, and immune cell activation. Additionally, the distinct effects of HDAC3 on various immune cell types—including its role in enhancing T cell activation, restoring NK cell cytotoxicity, promoting dendritic cell maturation, and modulating macrophage polarization—are thoroughly examined. These findings underscore HDAC3’s capacity to reshape the tumor immune microenvironment, converting immunologically “cold tumors” into “hot tumors” and thereby increasing their responsiveness to immunotherapy. The therapeutic potential of HDAC3 inhibitors is highlighted, both as standalone agents and in combination with immune checkpoint inhibitors, to overcome resistance and improve treatment efficacy. Innovative strategies, such as the development of selective HDAC3 inhibitors, advanced nano-delivery systems, and integration with photodynamic or photothermal therapies, are proposed to enhance treatment precision and minimize toxicity. By addressing challenges such as toxicity, patient heterogeneity, and resistance mechanisms, this study provides a forward-looking perspective on the clinical application of HDAC3 inhibitors. It highlights its significant potential in personalized cancer immunotherapy, paving the way for more effective treatments and improved outcomes for cancer patients. Full article
(This article belongs to the Special Issue Advances in Immunotherapy for T Cells and Tumors)
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