Vaccination and Alternative Immunotherapeutic Approaches against Emerging and (Re)emerging Neglected Tropical Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1069

Special Issue Editors


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Guest Editor
Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA
Interests: drug and vaccine development for Chagas disease and leishmaniasis; ecology of disease; biomarkers for diagnostics; treatment follow-up

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Guest Editor
Head of the Cell–Cell Interactions Laboratory, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil
Interests: immunoregulation of neglected tropical diseases, in particular Chagas disease, leishmaniasis and rheumatic heart disease; biomarkers of disease progression and severity and new immunotherapeutic approaches
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Special Issue Information

Dear Colleagues,

This Special Issue aims to compile the latest advancements in the realm of innovative and enhanced vaccine formulations targeting tropical neglected pathogens. Cutting-edge immunotherapeutic approaches and mechanisms underlying the intricate host–pathogen interactions fall under the scope of this Special Issue. In addition, we encourage submissions addressing the mechanisms of action that exert influences upon the viability of the pathogens within both intermediary (invertebrate) and mammalian (comprising animal models and humans) hosts. Contributions encompassing clinical trial investigations are also invited.

Prof. Dr. Rosa A. Maldonado
Prof. Dr. Walderez Ornelas Dutra
Guest Editors

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Keywords

  • antiviral vaccines
  • antiparasitic vaccines
  • antibacterial vaccines
  • immunotherapy of infectious diseases
  • adjuvants
  • immunological mechanisms
  • immunopathogenesis, innate and adaptive responses

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Published Papers (1 paper)

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Research

18 pages, 2445 KiB  
Article
Immunogenicity and Neutralization of Recombinant Vaccine Candidates Expressing F and G Glycoproteins against Nipah Virus
by Seo Young Moon, Rochelle A. Flores, Min Su Yim, Heeji Lim, Seungyeon Kim, Seung Yun Lee, Yoo-kyoung Lee, Jae-Ouk Kim, Hyejin Park, Seong Eun Bae, In-Ohk Ouh and Woo H. Kim
Vaccines 2024, 12(9), 999; https://doi.org/10.3390/vaccines12090999 - 31 Aug 2024
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Abstract
Nipah virus (NiV), of the Paramyxoviridae family, causes highly fatal infections in humans and is associated with severe neurological and respiratory diseases. Currently, no commercial vaccine is available for human use. Here, eight structure-based mammalian-expressed recombinant proteins harboring the NiV surface proteins, fusion [...] Read more.
Nipah virus (NiV), of the Paramyxoviridae family, causes highly fatal infections in humans and is associated with severe neurological and respiratory diseases. Currently, no commercial vaccine is available for human use. Here, eight structure-based mammalian-expressed recombinant proteins harboring the NiV surface proteins, fusion glycoprotein (F), and the major attachment glycoprotein (G) were produced. Specifically, prefusion NiV-F and/or NiV-G glycoproteins expressed in monomeric, multimeric (trimeric F and tetra G), or chimeric forms were evaluated for their properties as sub-unit vaccine candidates. The antigenicity of the recombinant NiV glycoproteins was evaluated in intramuscularly immunized mice, and the antibodies in serum were assessed. Predictably, all homologous immunizations exhibited immunogenicity, and neutralizing antibodies to VSV-luciferase-based pseudovirus expressing NiV-GF glycoproteins were found in all groups. Comparatively, neutralizing antibodies were highest in vaccines designed in their multimeric structures and administered as bivalent (GMYtet + GBDtet) and trivalent (Ftri + GMYtet + GBDtet). Additionally, while all adjuvants were able to elicit an immunogenic response in vaccinated groups, bivalent (GMYtet + GBDtet) and trivalent (Ftri + GMYtet + GBDtet) induced more potent neutralizing antibodies when administered with oil-in-water nano-emulsion adjuvant, AddaS03. For all experiments, the bivalent GMYtet + GBDtet was the most immunogenic vaccine candidate. Results from this study highlight the potential use of these mammalian-expressed recombinant NiV as vaccine candidates, deserving further exploration. Full article
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