Role of Gut Microbiota in Immune Tolerance and Vaccine Development

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 170

Special Issue Editor

E-Mail Website
Guest Editor
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Interests: gut microbiota; immune regulation; microbiome therapeutics; immune tolerance; autoimmunity; allergy; cancer

Special Issue Information

Dear Colleagues,

Immune tolerance, also known as immunological tolerance, refers to a state of active and highly regulated unresponsiveness of the immune system to self-antigens or a specific antigen that can induce an immune response in the body. It plays a crucial role in normal physiology, and deficiencies in tolerance can lead to autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes.

In recent years, considerable progress has been made in immune tolerance research, particularly in the fields of immunotherapy, immunomodulation, and immune system regulation. However, challenges persist due to incomplete knowledge of the exact mechanisms, a lack of suitable research models, and limited access to clinical data, making it difficult to develop effective treatments for diverse immune tolerance-related disorders.

This Special Issue will specifically address (but is not limited to) the following two topics:

  1. Cellular Aspects of Immune Tolerance in Health and Diseases: The Role of Immune Cell Subtypes and Their Crosstalk.

Immune tolerance involves interactions among various immune cell subtypes, such as T cells, B cells, macrophages, and dendritic cells. Crosstalk between these immune cell subtypes regulates the development of immune tolerance, enabling the body to recognize and accept self-antigens without triggering an immune response.

  1. The Role of Commensal Microbiota in Immune Tolerance and Vaccines.

Microorganisms, including beneficial bacteria in and on the body, play a vital role. Diseases like inflammatory bowel disease, allergies, asthma, and diabetes are linked to changes in microbiome composition. Commensal bacteria can reduce inflammation, downregulate pro-inflammatory responses, and enhance vaccine efficacy. Furthermore, they stimulate the production of protective antibodies, increasing vaccine effectiveness.

We welcome all types of articles, including original research, comprehensive and systematic reviews, brief reports, etc., for this Special Issue. We eagerly anticipate receiving your contributions.

Prof. Dr. Sin-Hyeog Im
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • immune tolerance
  • subtype of immune cells
  • microbiome
  • probiotics
  • T cells
  • B cells
  • dendritic cells
  • antigen-presenting cells

Published Papers

This special issue is now open for submission.
Back to TopTop