Porcine Circovirus Type 2: Pathogenicity, Host Response, Vaccine Efficacy, and the Role of Microbiota

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 307

Special Issue Editors


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Guest Editor
College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, OH, USA
Interests: rotavirus; glycans; mucus; bacteria; epitope

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Guest Editor
Department for Farm Animals, Division of Swine Medicine, University of Zurich, Zurich, Switzerland
Interests: transcription; immunology; porcine circovirus; vaccine
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Special Issue Information

Dear Colleagues,

Porcine circovirus 2 (PCV2) has been considered as a causative agent of several disorders, including postweaning multisystemic wasting syndrome (PMWS), enteric pathology, porcine dermatitis and nephropathy syndrome, in addition to respiratory and reproductive disorders. However, PCV2 infection in experimental conditions does not always meet clinical diseases reproduction expectations. More importantly, PCV2 pathogenesis and mechanisms of infection with low-level replication (sublinical form) are poorly understood. While vaccination against PCVAD is abundant and has been considered as a major control tool, the increasing diversity of PCV2 remains a major challenge for PCV2 vaccine efficacy.  Taken together, these data suggest that, along with the role of PCV2 genotype-/strain-specific effect, host factors including microbiota composition may contribute to disease outcome.

The research scope of this Special Issue includes, but is not limited to: (1) the molecular epidemiology of porcine circoviruses (including PCV3 and PCV4); (2) the impact of genetically diverse porcine circoviruses on effectiveness of PCV2 vaccination; (3) the role of host factors such as microbiota composition in PCV2 infection/vaccination; and (4) molecular footprints of the host cells in response to PCV2 infection in vitro and in vivo.

Dr. Sergei Raev
Dr. Enrico Brugnera
Guest Editors

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Keywords

  • vaccine
  • immunogenicity
  • entry
  • replication
  • co-infection
  • microbiota
  • host response

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