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Article

Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain

by
Juan David Puyana Ortiz
1,†,
Andrea Carolina Garcés Rodríguez
2,†,
María Luisa Aznar
3,4,5,*,
Juan Espinosa Pereiro
3,4,5,
Adrián Sánchez-Montalvá
3,4,5,
Joan Martínez-Campreciós
3,4,
Nuria Saborit
3,
José Ángel Rodrigo-Pendás
6,
Guadalupe García Salgado
3,
Claudia Broto Cortes
3,
Nuria Serre Delcor
3,4,
Inés Oliveira
3,4,
Begoña Treviño Maruri
3,4,
Diana Pou Ciruelo
3,4,
Fernando Salvador
3,4,
Pau Bosch-Nicolau
3,4,
Irene Torrecilla-Martínez
6,
Ricardo Zules-Oña
6,
María Teresa Tórtola Fernández
4,7 and
Israel Molina
3,4
1
International Health and Cooperation UAB, 08193 Barcelona, Spain
2
Morales Meseguer University Hospital, 30008 Murcia, Spain
3
International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, Vall d’Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain
4
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
5
Grupo de Estudio de Micobacterias (GEIM), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC), 28003 Madrid, Spain
6
Preventive Medicine and Epidemiology Department, Vall d’Hebron University Hospital, 08035 Barcelona, Spain
7
Microbiology Department, Vall d’Hebron University Hospital, 08035 Barcelona, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Trop. Med. Infect. Dis. 2023, 8(7), 373; https://doi.org/10.3390/tropicalmed8070373
Submission received: 18 May 2023 / Revised: 12 July 2023 / Accepted: 13 July 2023 / Published: 19 July 2023
(This article belongs to the Special Issue Tuberculosis: Novel Insights and Approaches to Tackle an Ancient Disease)
Review Reports Versions Notes

Abstract

The screening and treatment of latent tuberculosis infection (LTBI) in countries with a low incidence of TB is a key strategy for the elimination of tuberculosis (TB). However, treatment can result in adverse events (AEs) and have poor adherence. This study aimed to describe treatment outcomes and AEs for LTBI patients at two departments in Vall d’Hebron University Hospital in Barcelona, Spain. A retrospective study was conducted on all persons treated for LTBI between January 2018 and December 2020. Variables collected included demographics, the reason for LTBI screening and treatment initiation, AEs related to treatment, and treatment outcome. Out of 261 persons who initiated LTBI treatment, 145 (55.6%) were men, with a median age of 42.1 years. The indications for LTBI screening were household contact of a TB case in 96 (36.8%) persons, immunosuppressive treatment in 84 (32.2%), and recently arrived migrants from a country with high TB incidence in 81 (31.0%). Sixty-three (24.1%) persons presented at least one AE during treatment, and seven (2.7%) required definitive discontinuation of treatment. In the multivariate analysis, AE development was more frequent in those who started LTBI treatment due to immunosuppression. Overall, 226 (86.6%) completed treatment successfully. We concluded that LTBI screening and treatment groups had different risks for adverse events and treatment outcomes. Persons receiving immunosuppressive treatment were at higher risk of developing AEs, and recently arrived immigrants from countries with a high incidence of TB had greater LTFU. A person-centered adherence and AE management plan is recommended.
Keywords: Mycobacterium tuberculosis; tuberculosis screening; latent tuberculosis infection; adverse events; toxicity; adherence Mycobacterium tuberculosis; tuberculosis screening; latent tuberculosis infection; adverse events; toxicity; adherence

Share and Cite

MDPI and ACS Style

Puyana Ortiz, J.D.; Garcés Rodríguez, A.C.; Aznar, M.L.; Espinosa Pereiro, J.; Sánchez-Montalvá, A.; Martínez-Campreciós, J.; Saborit, N.; Rodrigo-Pendás, J.Á.; García Salgado, G.; Broto Cortes, C.; et al. Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain. Trop. Med. Infect. Dis. 2023, 8, 373. https://doi.org/10.3390/tropicalmed8070373

AMA Style

Puyana Ortiz JD, Garcés Rodríguez AC, Aznar ML, Espinosa Pereiro J, Sánchez-Montalvá A, Martínez-Campreciós J, Saborit N, Rodrigo-Pendás JÁ, García Salgado G, Broto Cortes C, et al. Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain. Tropical Medicine and Infectious Disease. 2023; 8(7):373. https://doi.org/10.3390/tropicalmed8070373

Chicago/Turabian Style

Puyana Ortiz, Juan David, Andrea Carolina Garcés Rodríguez, María Luisa Aznar, Juan Espinosa Pereiro, Adrián Sánchez-Montalvá, Joan Martínez-Campreciós, Nuria Saborit, José Ángel Rodrigo-Pendás, Guadalupe García Salgado, Claudia Broto Cortes, and et al. 2023. "Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain" Tropical Medicine and Infectious Disease 8, no. 7: 373. https://doi.org/10.3390/tropicalmed8070373

APA Style

Puyana Ortiz, J. D., Garcés Rodríguez, A. C., Aznar, M. L., Espinosa Pereiro, J., Sánchez-Montalvá, A., Martínez-Campreciós, J., Saborit, N., Rodrigo-Pendás, J. Á., García Salgado, G., Broto Cortes, C., Delcor, N. S., Oliveira, I., Treviño Maruri, B., Ciruelo, D. P., Salvador, F., Bosch-Nicolau, P., Torrecilla-Martínez, I., Zules-Oña, R., Tórtola Fernández, M. T., & Molina, I. (2023). Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain. Tropical Medicine and Infectious Disease, 8(7), 373. https://doi.org/10.3390/tropicalmed8070373

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