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Tropical Medicine and Infectious Disease, Volume 11, Issue 5

2026 May - 33 articles

Cover Story: Strongyloides stercoralis is a soil transmitted helminth capable of establishing chronic infection through an autoinfective cycle. In immunocompromised individuals, corticosteroid exposure can trigger life-threatening hyperinfection syndrome. We report a 70 year old man from an endemic region in Colombia with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage following corticosteroid therapy for spinal cord compression. Bronchoalveolar lavage confirmed S. stercoralis larvae, establishing the diagnosis. Despite ivermectin therapy, the patient died due to rapid clinical deterioration. This case highlights the critical importance of screening for strongyloidiasis before initiating immunosuppression in endemic settings. View this paper
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Articles (33)

  • Article
  • Open Access
1,297 Views
12 Pages

Evaluating the Usability, Durability, and Effectiveness of Permethrin-Treated Uniforms and Metofluthrin Spatial Repellent in Preventing Mosquito Bites in the Laos Military

  • Parat Boonyarangka,
  • Pheutsapha Sonthilath,
  • Sidhartha Chaudhury,
  • Virasack Banouvong and ,
  • Worachet Kuntawunginn,
  • Siriporn Sornsakrin,
  • Bounor Taobouathong,
  • Thavone Sinhthapaseuth,
  • Utaiwan Srichairatanakul and
  • Krisada Jongsakul
  • + 15 authors+ 10 authors

While vector control methods have successfully reduced malaria rates worldwide, such methods are not always suitable for military use. We evaluated the usability, durability, and effectiveness of permethrin-treated uniforms and metofluthrin spatial r...

(This article belongs to the Special Issue Military Medicine: An Everlasting War against Tropical and Infectious Diseases)
  • Perspective
  • Open Access
1,669 Views
10 Pages

Tafenoquine: A Breakthrough Option for Babesiosis Treatment

  • Dongxue Ma,
  • Mo Zhou,
  • Shinuo Cao,
  • Eloiza May Galon-Bedonia and ,
  • Zhiqiang Xu,
  • Chenghui Li,
  • Xu Gao,
  • Shujiang Xue and
  • Shengwei Ji
  • + 4 authors+ 0 author

Babesiosis is a zoonosis caused by protozoan parasites of the genus Babesia. It has a worldwide distribution and affects many kinds of mammals, principally domestic animals and humans. Because there are no safe and effective vaccines available, the t...

(This article belongs to the Special Issue New Strategies for the Diagnosis, Treatment and Risk Assessment of Parasitic Disease)
  • Article
  • Open Access
2,004 Views
15 Pages

Unveiling Clinical Phenotypes in Chronic Chikungunya Disease: Insights from a Brazilian Observational Study

  • Karen Santos Lima,
  • Adriane Paz Rocha,
  • Alice Lanna Damásio Castro,
  • Anna Carolina Faria Moreira Gomes Tavares and ,
  • Flávia Patrícia Sena Teixeira Santos,
  • Gilda Aparecida Ferrreira,
  • Livia Barbara Cordeiro Alves,
  • Josiane Lino dos Santos Frattari,
  • Juliana Froeseler Fittipaldi and
  • Mauro Martins Teixeira
  • + 11 authors+ 6 authors

Chronic chikungunya disease (CCD) affects approximately 30–50% of infected individuals and is associated with persistent inflammatory arthritis, chronic pain, and long-term functional disability. We conducted a prospective observational cohort...

(This article belongs to the Special Issue Arboviral Infections: Pathogenesis and Immunity)
  • Editorial
  • Open Access
414 Views
4 Pages

Mycobacterial diseases, particularly tuberculosis (TB), continue to impose a substantial global health burden, disproportionately affecting populations in low- and middle-income countries [...]

(This article belongs to the Special Issue Biomarkers, Diagnostic, and Therapeutic Approaches for Mycobacterial Diseases)
  • Case Report
  • Open Access
853 Views
9 Pages

First Usutu Virus Infection in an Asymptomatic Blood Donor in Greece

  • Anna Papa,
  • Katerina Tsioka,
  • Styliani Pappa,
  • Danai Pervanidou and ,
  • Constantina Politis,
  • Kostas Stamoulis and
  • Vassiliki Bakaloudi
  • + 2 authors+ 0 author

Usutu virus (USUV) is a mosquito-borne flavivirus, widely distributed in Central Europe, where it causes avian outbreaks with large-scale mortality. Although most human infections are asymptomatic or mild, the reports of USUV neurologic infections ar...

  • Article
  • Open Access
1,181 Views
21 Pages

Impact of Insecticide-Treated Nets on Plasmodium falciparum Infection Rates: A Meta-Analysis

  • Nevra Karaca Biçakçi,
  • Ayşe Çalmaz,
  • Merve Ayyildiz Akin,
  • Ching Siang Tan and ,
  • Jayanthi Barasarathi,
  • Babatunji E. Oyinloye,
  • Annaev Umidjon,
  • Kuvonchbek Egamberdiyev and
  • Intizor Avazmetova
  • + 4 authors+ 0 author

Insecticide-treated nets (ITNs), particularly long-lasting insecticide-treated nets (LLINs), are important for malaria control; however, the rise of insecticide resistance, behavioral adaptations in mosquito vectors, and diminishing net durability ma...

(This article belongs to the Section Vector-Borne Diseases)
  • Article
  • Open Access
1 Citations
1,512 Views
20 Pages

Rift Valley fever (RVF) is a viral zoonosis endemic in Madagascar, threatening human and animal health as well as the economy. Trade-related livestock movements are a major factor in the spread of RVF virus. While previous RVF research in Madagascar...

(This article belongs to the Section One Health)
  • Article
  • Open Access
3 Citations
1,450 Views
15 Pages

Human Metapneumovirus G Protein Immunogenicity and Safety Explored via Carrier Protein Fusion

  • Tian Ren,
  • Kailun Ma,
  • Xinmiao Lai,
  • Jizheng Chen and
  • Changgui Li

Human metapneumovirus (HPMV) is a significant pathogen that causes lower respiratory tract infections. Given the weak immunogenicity thereof, and the few relevant studies, the utility of the viral membrane protein G as a vaccine remains controversial...

(This article belongs to the Special Issue Immune Responses in Respiratory Infections)
  • Article
  • Open Access
3 Citations
1,070 Views
22 Pages

Oviposition Deterrent and Larvicidal Activity of Salvia munzii Essential Oil Against Susceptible and Insecticide-Resistant Aedes aegypti

  • Selene M. Gutierrez-Rodriguez,
  • Ivan Cordova-Guerreo,
  • Laura Diaz-Rubio,
  • Jesus A. Davila-Barboza and ,
  • Iram P. Rodriguez-Sanchez,
  • Beatriz Lopez-Monroy,
  • Sergio A. Galindo-Rodriguez and
  • Adriana E. Flores
  • + 3 authors+ 0 author

The increasing prevalence of insecticide resistance in Aedes aegypti threatens the effectiveness of chemical vector control and highlights the need for alternative approaches targeting mosquito behavior. This study evaluated the oviposition deterrent...

(This article belongs to the Special Issue Insecticide Resistance and Vector Control, 2nd Edition)
  • Case Report
  • Open Access
3 Citations
1,328 Views
9 Pages

Background: Strongyloides stercoralis is a soil-transmitted helminth capable of establishing chronic infection through an autoinfective cycle, with the potential to progress to life-threatening hyperinfection, particularly in immunocompromised indivi...

(This article belongs to the Special Issue Advances in Strongyloidiasis: Celebrating the Tenth Anniversary of Tropical Medicine and Infectious Disease and a Special Tribute in Memory of Professor Rick Speare (1946–2016))
  • Case Report
  • Open Access
1 Citations
1,017 Views
11 Pages

Clinical Experience of Therapeutic Plasma Exchange (TPE) in Severe Leptospirosis: A Case Series from Sri Lanka

  • Manana Dewage Sankani Vishvara Kularathna and
  • Senanayake Abeysinghe Mudiyanselage Kularatne

Background: Leptospirosis is a globally prevalent zoonosis with significant morbidity and mortality, especially in tropical regions like South Asia. In its severe form, the disease often leads to multiorgan dysfunction, with pulmonary haemorrhage bei...

(This article belongs to the Section Infectious Diseases)
  • Systematic Review
  • Open Access
3 Citations
1,497 Views
15 Pages

Spatiotemporal Patterns and Historical Overview of Aedes Mosquitoes in Iran: A Systematic Review

  • Jalil Nejati,
  • Abedin Saghafipour,
  • Mahsa Sarvi and
  • Rubén Bueno-Marí

Aedes mosquitoes are among the most important vectors of arboviral diseases such as dengue, Zika, and chikungunya. Mapping their geographic and temporal patterns is essential for understanding disease risk and guiding vector control. This systematic...

(This article belongs to the Special Issue Global Perspectives on the Role of Invasive Mosquito Species and Emerging Vector-Borne Diseases)
  • Article
  • Open Access
1 Citations
1,857 Views
18 Pages

Time-Series Analysis and Age-Stratified Forecasting of Diarrheal Disease in Rwanda Using SARIMA Models

  • Theos Dieudonne Benimana,
  • Martin Habimana,
  • Jean de Dieu Harerimana,
  • Eric Mugabo and ,
  • Thierry Sebakunzi,
  • Patrick Niyonshuti,
  • Valens Rwema,
  • Muhammed Semakula and
  • Seung-sik Hwang
  • + 4 authors+ 0 author

Background: Diarrheal disease remains a major and persistent cause of morbidity and mortality in Rwanda, with substantial seasonal surges that strain routine services; however, transparent and operationally interpretable national forecasting has been...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
932 Views
16 Pages

Background: Childhood tuberculosis (TB) is a major but underappreciated threat to human health. Because diagnosis of tuberculosis in children is difficult, there are a lack of accurate global statistics. This study aimed to comprehensively assess the...

(This article belongs to the Special Issue Innovative Tools and Strategies for Tuberculosis (TB) Detection: Advancing Diagnosis Through Technology, Integration, and Equity)
  • Review
  • Open Access
3 Citations
2,339 Views
15 Pages

Dengue NS1 as a Driver of Immune-Mediated Pathogenesis

  • Upeksha S. Wanigarathna,
  • Senaka Rajapakse,
  • Sisira L. Pathirana,
  • Shiroma M. Handunnetti and ,
  • Andreas Nitsche and
  • Narmada Fernando
  • + 1 author+ 0 author

Dengue infection remains a major global health concern, with a subset of patients progressing from self-limited dengue fever to severe disease characterised by plasma leakage, shock, and organ dysfunction. The dengue non-structural protein 1 (NS1), a...

(This article belongs to the Special Issue Arboviral Infections: Pathogenesis and Immunity)
  • Article
  • Open Access
2,499 Views
15 Pages

Sentinel Surveillance of Influenza A in Libya: Subtyping and Genomic Analysis During Recent Seasons (2022–2024)

  • Mahmud Azbida,
  • Sana Ferjani,
  • Omar Elahmer,
  • Rmadhan Osman and ,
  • Salem Shenaisheh,
  • Amal Barakat,
  • Salma Abid,
  • Adem Eljerbi,
  • Abdulwahab Kammon and
  • Ibrahim Eldaghayes
  • + 8 authors+ 3 authors

Influenza sentinel surveillance in Libya was formally established in 2022 by the Libyan National Center for Disease Control (NCDC). Between 2022 and 2024, a total of 1864 nasopharyngeal specimens were collected from patients presenting with influenza...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
1,629 Views
14 Pages

New Data on Ixodid Ticks and Their Infection with Borrelia and Coxiella burnetii in Vietnam

  • Nguyen Van Hiep,
  • Tatiana A. Bondarenko,
  • Le Thi Lan Anh,
  • Olga A. Stukolova and ,
  • Luong Thi Mo,
  • Kseniia A. Sycheva,
  • Vien Chinh Chien,
  • Alex L. Viskontene,
  • Nguyen Thi Dung and
  • Marat T. Makenov
  • + 14 authors+ 9 authors

The distribution of medically significant ticks in Vietnam requires ongoing monitoring. This study presents data on tick distribution and molecular screening for Borrelia spp. and Coxiella burnetii DNA. Ticks were collected from domestic animals and...

(This article belongs to the Section Vector-Borne Diseases)
  • Article
  • Open Access
2 Citations
1,262 Views
11 Pages

Knowledge, Attitudes, and Preparedness Regarding Marburg Virus Disease Among Healthcare Workers in Awi Zone Public Hospitals, Northwest Ethiopia: A Multicenter Cross-Sectional Study

  • Ayenew Genet Kebede,
  • Zewdu Bishaw Aynalem,
  • Aragaw Egziabherfenta Tadele,
  • Belachew Tegegne and ,
  • Asrat Yazew,
  • Betelhem Mekonnen Alem,
  • Lalem Tilahun,
  • Tamene Fetene Terefe,
  • Getachew Amare and
  • Yonas Wondie
  • + 7 authors+ 2 authors

Background: An outbreak of Marburg virus in Jinka Town, Southern Ethiopia, has raised significant concern regarding the potential spreading of disease throughout the country. Healthcare workers play a crucial role in early prevention and control of s...

(This article belongs to the Section Infectious Diseases)
  • Review
  • Open Access
1 Citations
1,562 Views
11 Pages

A decade has elapsed since the first recognized cluster of congenital anomalies associated with Zika virus (ZIKV) was reported in Brazil in 2015, culminating in the formal delineation of Congenital Zika Syndrome (CZS) as a specific pattern of birth d...

(This article belongs to the Special Issue Emerging Vector-Borne Diseases and Public Health Challenges)
  • Article
  • Open Access
1,757 Views
17 Pages

Challenges to ‘Last Mile’ Surveillance: Result of Programmatic Review of Integrated Skin NTDs Surveillance in Three Indonesian Districts

  • Agrin Zauyani Putri,
  • Ajib Diptyanusa,
  • Regina Tiolina Sidjabat,
  • Yatinawati Yatinawati and ,
  • Yety Intarti,
  • Irma Surya Kusuma,
  • Khadijah Qurrata Ayun,
  • Trijoko Yudopuspito,
  • Muhammad Anwar Simanullang and
  • Yullita Evarini Yuzwar
  • + 8 authors+ 3 authors

Indonesia is approaching the ‘last mile’ of elimination for several skin-related neglected tropical diseases (skin NTDs): notably, leprosy, yaws and lymphatic filariasis (LF). However, persistent transmission in selected districts highlig...

(This article belongs to the Special Issue Surveillance of Eliminated and Near-Eliminated Infectious Disease in the Western Pacific Region)
  • Article
  • Open Access
1,343 Views
15 Pages

Plasmodium falciparum Malaria and Arbovirus Co-Exposure in the Boende Health Zone, Northwestern Democratic Republic of the Congo

  • Solange Milolo Tshilumba,
  • Ynke Larivière,
  • Trésor Zola Matuvanga,
  • Armand Mutwadi and ,
  • Danoff Engbu,
  • Germain Kapour,
  • Gwen Lemey,
  • Maha Salloum,
  • Maeliss Champagne and
  • Patrick Mitashi-Mulopo
  • + 12 authors+ 7 authors

Background: Malaria remains hyperendemic in the Democratic Republic of the Congo, while arboviral infections are increasingly reported but remain under-surveilled, particularly in remote regions. Overlapping ecological niches and non-specific clinica...

(This article belongs to the Special Issue Advances in Tools for Battling Malaria)
  • Article
  • Open Access
1 Citations
1,990 Views
18 Pages

Effects of Lactococcus lactis Strain Plasma (LC-Plasma) Intake on Infection-Related Symptoms Among Healthcare Workers: A Randomized, Double-Blind, Placebo-Controlled Study

  • Zhao Xuan Low,
  • Nghiem Nguyet Thu,
  • Truong Tuyet Mai,
  • Tran Thanh Duong and ,
  • Pouya Hassandarvish,
  • Vunjia Tiong,
  • Nguyen Thi Thu Thuy,
  • Nguyen Thi Tham,
  • Cap Minh Duc and
  • Sazaly Abubakar
  • + 6 authors+ 1 author

The rising health threat to healthcare workers (HCWs) demands innovative preventive solutions that are affordable, scalable, and easy to deploy, especially in resource-limited settings. This present study investigated the effects of Lactococcus lacti...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
662 Views
13 Pages

Rural Residence and One-Person Households Are Associated with Diagnostic Delay in Pulmonary Tuberculosis in a Low-Incidence European Setting

  • Tatjana Munko,
  • Vesna Vukičević Lazarević,
  • Jelena Barišić,
  • Marina Perković and
  • Tanja Vignjević

Objectives: Diagnostic delay in pulmonary tuberculosis remains a significant barrier to effective disease control, even in low-incidence settings. This study aimed to identify factors associated with total delay and its components among adults with p...

(This article belongs to the Special Issue Tuberculosis Diagnosis: Current, Ongoing and Future Approaches)
  • Brief Report
  • Open Access
1,531 Views
8 Pages

Diagnostic Performance of Two Commercial qPCR Kits for Leptospira spp. Detection

  • Andrés Esteban Barragán-Peña,
  • Darwin Paredes-Núñez,
  • Fabiola Jimenez Valenzuela,
  • Solon Alberto Orlando and ,
  • Elsy Carvajal,
  • Angel Sebastian Rodriguez-Pazmiño and
  • Miguel Angel Garcia-Bereguiain
  • + 2 authors+ 0 author

Early confirmation of leptospirosis is essential for prompt antimicrobial treatment, and PCR-based diagnosis has been reported as a highly sensitive method during the acute phase in the first week since the symptom’s onset. We evaluated the dia...

(This article belongs to the Special Issue Molecular Diagnostics for Tropical Infectious Diseases)
  • Article
  • Open Access
1,494 Views
9 Pages

Evaluation of Parasite Concentrator Kit and Kato–Katz Method for Detection of Intestinal Parasites in Stool Samples

  • Penchom Janwan,
  • Lakkhana Sadaow,
  • Patcharaporn Boonroumkaew,
  • Rutchanee Rodpai and ,
  • Oranuch Sanpool,
  • Tongjit Thanchomnang,
  • Pokkamol Laoraksawong,
  • Pewpan Maleewong Intapan and
  • Wanchai Maleewong
  • + 4 authors+ 0 author

Background: To address the significant burden of helminthiases in Thailand, this cross-sectional study compared the performance of a fecal parasite concentrator kit (FPCK) against the Kato–Katz (KK) method for diagnosing intestinal parasites in...

  • Brief Report
  • Open Access
1,245 Views
9 Pages

Meningovascular syphilis, a type of neurosyphilis, causes stroke and various types of myelopathy. In recent years, there has been an increase in the incidence of neurosyphilis. However, diagnosing neurosyphilis remains challenging due to the reliance...

(This article belongs to the Special Issue Molecular Diagnostics for Tropical Infectious Diseases)
  • Article
  • Open Access
1,154 Views
15 Pages

Hospital Cost Components and Predictors in Escherichia coli Bacteremia

  • Tri Pudy Asmarawati,
  • Fikri Sasongko Widyatama,
  • Hari Basuki Notobroto,
  • Erwin Astha Triyono and ,
  • Nasronudin Nasronudin,
  • Motoyuki Sugai and
  • Kuntaman Kuntaman
  • + 2 authors+ 0 author

Background/Objectives: Escherichia coli bacteremia is a major cause of morbidity, mortality, and healthcare expenditure. The increasing prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) complicates manage...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
842 Views
14 Pages

Hearing Assessment in HIV-Exposed-Uninfected Infants

  • Amanda Zanatta Berticcelli,
  • Andréa Lúcia Corso,
  • Pâmela Panassol,
  • Leticia Petersen Schmidt Rosito and ,
  • Roberta Rahal de Albuquerque,
  • Letícia de Paula e Souza,
  • Milena Lessa da Silva,
  • Sady Selaimen da Costa and
  • Luciana Friedrich
  • + 4 authors+ 0 author

Background: Among the complications caused directly or indirectly by the Human Immunodeficiency Virus (HIV) are alterations in the auditory system. Children who are HIV-exposed but uninfected (HEU) appear to have a higher risk of hearing loss (HL) co...

(This article belongs to the Special Issue HIV Elimination: Addressing Challenges in Vulnerable Populations and Reducing Discrimination)
  • Review
  • Open Access
2,335 Views
24 Pages

Despite prolonged viral inhibition with combination antiretroviral therapy (ART), HIV-1 survives as genetically intact, replication-capable proviruses within durable CD4+ T-cell fractions, involving central memory, transitional memory, and stem cell-...

(This article belongs to the Special Issue HIV Elimination: Addressing Challenges in Vulnerable Populations and Reducing Discrimination)
  • Review
  • Open Access
804 Views
15 Pages

Malaria is one of the major global public health issues. An estimated 282 million malaria cases occurred worldwide in 2024, and the overall prevention and control progress has stagnated or even reversed in some regions. Mass drug administration (MDA)...

(This article belongs to the Special Issue Advances in Tools for Battling Malaria)
  • Article
  • Open Access
1,589 Views
20 Pages

Brucella abortus Infection Promotes Mesenchymal Stem Cell Differentiation Toward Adipogenesis, Enhancing the Proinflammatory Profile

  • Rosa Nicole Freiberger,
  • Cynthia Alicia Marcela López,
  • María Belén Palma,
  • Cintia Cevallos and ,
  • Franco Agustin Sviercz,
  • Patricio Jarmoluk,
  • Marcela Nilda García,
  • Jorge Quarleri and
  • M. Victoria Delpino
  • + 4 authors+ 0 author

The most common complication of active brucellosis in humans is osteoarticular injury. In the bone marrow microenvironment, mesenchymal stem cells (MSCs) can differentiate into either adipocytes or osteoblasts, and this balance is tightly regulated b...

(This article belongs to the Special Issue Advances in Brucella Infections)
  • Brief Report
  • Open Access
1,385 Views
13 Pages

Effectiveness and Sustainability of Water Chlorination in Public Healthcare Services in Guatemala

  • Paulina Garzaro,
  • Carmen Castillo,
  • Natalie Fahsen,
  • Lucas Santos and ,
  • Joyce Lu,
  • Christiana Hug,
  • Matthew Lozier,
  • Douglas R. Call,
  • Celia Cordón-Rosales and
  • Brooke M. Ramay
  • + 5 authors+ 0 author

Introduction: Healthcare-associated infections are a significant public health challenge, particularly in resource-limited settings. While hand hygiene is critical for infection prevention, contaminated water from hand hygiene stations (HHSs) in heal...

(This article belongs to the Special Issue Epidemiology and Public Health in Tropical Regions of Central America)
  • Review
  • Open Access
1,926 Views
14 Pages

Furuncular myiasis is rarely reported in Southeast/Eastern Europe and may be underrecognized or misdiagnosed in non-endemic settings. We described two imported furuncular myiasis cases diagnosed in Romania following travel to Peru and confirmed the e...

(This article belongs to the Section Travel Medicine)
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Trop. Med. Infect. Dis. - ISSN 2414-6366