Venom Gene Evolution: Past, Present and Future

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3081

Special Issue Editor


E-Mail Website
Guest Editor
Animal Venomics Group, Justus Leibig University, 35394 Giessen, Germany
Interests: evolution of function; gene evolution; comparative genomics; origin of venom genes

Special Issue Information

Dear Colleagues,

Ongoing advances in sequencing platforms have generated a tremendous wealth of data, and their impact on the research of venom gene evolution has already been documented. A simplistic picture of venom genes emerging via duplication followed by a neofunctionalization is being questioned, with multiple high-profile studies participating in this exciting scientific debate. Many crucial questions remain open: Do venom genes share a common origin pattern? Are there any genomic or protein structure effects that increase the chance of a gene being weaponised into venom? Do venoms evolve repeatedly within the same clade or is it a predominantly singular event within each of the venomous taxa? And many more. Some of these questions can be answered already, some might be ripe for a machine learning approach, yet some might remain forever open. The aim of this Special Issue is to provide a snapshot of the field of venom gene evolution and to serve as a topical roadmap of the field in the future.

Dr. Ivan Koludarov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venom genes evolution
  • current state of venom genetics
  • patterns in venom evolution

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 2540 KiB  
Article
Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus
by Han Zhang, Anwen Liang and Xinghua Pan
Toxins 2022, 14(2), 99; https://doi.org/10.3390/toxins14020099 - 26 Jan 2022
Cited by 1 | Viewed by 2606
Abstract
Conotoxins are tools used by marine Conus snails to hunt and are a significant repository for marine drug research. Conotoxins highly selectively coordinate different subtypes of various ion channels, and a few have been used in pain management. Although more than 8000 conotoxin [...] Read more.
Conotoxins are tools used by marine Conus snails to hunt and are a significant repository for marine drug research. Conotoxins highly selectively coordinate different subtypes of various ion channels, and a few have been used in pain management. Although more than 8000 conotoxin genes have been found, the biological activity and function of most have not yet been examined. In this report, we selected the toxin gene QcMNCL-XIII0.1 from our previous investigation and studied it in vitro. First, we successfully prepared active recombinant QcMNCL-XIII0.1 using a TrxA (Thioredoxin A)-assisted folding expression vector based on genetic engineering technology. Animal experiments showed that the recombinant QcMNCL-XIII0.1 exhibited nerve conduction inhibition similar to that of pethidine hydrochloride. With flow cytometry combined fluorescent probe Fluo-4 AM, we found that 10 ng/μL recombinant QcMNCL-XIII0.1 inhibited the fluorescence intensity by 31.07% in the 293T cell model transfected with Cav3.1, implying an interaction between α1G T-type calcium channel protein and recombinant QcMNCL-XIII0.1. This toxin could be an important drug in biomedical research and medicine for pain control. Full article
(This article belongs to the Special Issue Venom Gene Evolution: Past, Present and Future)
Show Figures

Figure 1

Back to TopTop