Special Issue "Toxins and Ion Channels"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (30 April 2018)
Dr. Evelyne BENOIT
Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des Sciences du Vivant Frédéric Joliot, Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay, bâtiment 152, F-91191 Gif-sur-Yvette, France & Institut des Neurosciences Paris-Saclay, UMR 9197 CNRS/Université Paris-Sud, CNRS, F-91190 Gif-sur-Yvette, France
Phone: +33 1 6908 5685
Fax: +33 1 6908 9071
Interests: toxins; voltage-gated sodium channels; voltage-gated potassium channels; voltage-gated calcium channels; nicotinic acetylcholine receptors; venom toxins; marine toxins; bacterial toxins
Dr. Jordi Molgó
1 Institut des Neurosciences Paris-Saclay, UMR 9197 CNRS/Université Paris-Sud, CNRS, F-91190 Gif-sur-Yvette, France
2 CEA, Institut des Sciences du Vivant Frédéric Joliot, Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay, bâtiment 152, F-91191 Gif-sur-Yvette, France
Website | E-Mail
Phone: +33 1 6908 5158
Fax: +33 1 6908 9071
Interests: natural toxins from marine and terrestrial organisms; voltage-gated ion channels; nicotinic acetylcholine receptors; cholinesterases; IP3 receptors; cell signaling; synaptic transmission
Toxins are usually potent and selective for a given molecular target, and have been frequently used as probes of the structure and function of voltage-gated and ligand-gated ion channels. For these reasons, toxins are of substantial interest, as both pharmacological tools and therapeutic leads. They are, thus, particularly interesting for the pharmaceutical industry. Numerous ion channels constitute important targets for the treatment of neurological or cardiovascular diseases. In addition, the ligand-gated ion channels including nicotinic acetylcholine (nAChR), serotonin type 3 (5-HT3R), γ-aminobutyric acid (GABAAR), and glycine (GlyR) receptors are of great physiological relevance in many neurological disease pathways. In this Special Issue we welcome papers dealing with new toxins and/or new targets from natural sources or from engineering (chemical or recombinant synthesis). Emphasis on toxin-induced biophysical and pharmacological channel modulation, as well as modeling of toxin-target interactions, will be highly appreciated. Additionally, the selection of toxins with well-characterized mode and mechanism of action is relevant, since these toxins may provide scaffolds for drug design studies and will advance our knowledge and understanding of ion channels in common or neglected diseases.
Dr. Evelyne BENOIT
Dr. Jordi MOLGO
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Toxins and voltage-gated ion channels
- Toxins and ligand-gated channels
- New toxins
- New toxin target(s)
- Natural and synthetic toxins
- Toxin engineering
- Toxin high-throughput screening
- Toxins and channel modulation
- Modeling of toxin-target interactions
- Toxins and drug discovery