marinedrugs-logo

Journal Browser

Journal Browser

Marine Biotoxins, 4th Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Toxins".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 295

Special Issue Editor


E-Mail Website
Guest Editor
Service d’Ingénierie Moléculaire pour la Santé (SIMoS), EMR CNRS 9004, Département Médicaments et Technologies pour la Santé (DMTS), Institut des Sciences du Vivant Frédéric Joliot, Commissariat à l’énergie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, Point Courrier 24, F-91191 Gif sur Yvette, France
Interests: natural toxins from marine and terrestrial organisms; voltage-gated ion channels; ligand gated channels; nicotinic acetylcholine receptors; cholinesterases; IP3 receptors; cell signaling; synaptic transmission; neuromuscular transmission; transmitter release
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this new Special Issue titled Marine Biotoxins, 4th Edition, we invite the submission of manuscripts that explore the microorganisms responsible for marine biotoxin production—including bacteria, cyanobacteria, dinoflagellates, diatoms, and fungi—as well as the environmental conditions that promote their proliferation and transfer through the marine food web. The accumulation of marine biotoxins in invertebrates, fish, birds, and marine mammals poses a serious threat to wildlife, and several of these toxins also represent significant risks to human health through the consumption of contaminated seafood. As a result, regulatory thresholds must be continually assessed and refined to ensure food safety.

Marine biotoxins comprise various families of organic compounds with complex and diverse chemical structures, with new toxins continuing to be discovered each year. These toxins act on a wide range of cellular targets, including the following:

(i) Voltage-gated ion channels (Na⁺, K⁺, and Ca²⁺);
(ii) Ionotropic or ligand-gated receptors—such as glutamate (AMPA, kainate, and NMDA), nicotinic acetylcholine, 5-HT₃ (serotonin), and GABA-A receptors;
(iii) Metabotropic receptors, particularly G protein-coupled receptors which are linked to adenylate cyclase (Gs, Gi/o) or phospholipase C-β;
(iv) Intracellular cytosolic and nuclear receptors that influence gene transcription;
(v) Second messengers like calcium, inositol trisphosphate (IP₃), and diacylglycerol, which play critical roles in their mechanisms of action

Gaining a deeper understanding of the cellular and molecular targets, signaling pathways, and toxic mechanisms of marine biotoxins will be key to identifying potential antagonists and developing effective countermeasures.

Prof. Dr. Jordi Molgó
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine biotoxins
  • cellular and molecular targets
  • signaling pathways
  • metabolism
  • toxicity
  • risk factors
  • molecular interactions
  • therapeutic potential
  • ion channels
  • Ionotropic receptors
  • ligand-gated receptors
  • metabotropic receptors

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 2583 KB  
Article
High Inter- and Intraspecific Variability in Amphidinol Content and Toxicity of Amphidinium Strains
by Catharina Alves-de-Souza, Jannik Weber, Mathew Schmitt, Robert York, Sarah Karafas, Carmelo Tomas and Bernd Krock
Mar. Drugs 2025, 23(9), 332; https://doi.org/10.3390/md23090332 - 22 Aug 2025
Viewed by 189
Abstract
Amphidinols (AM) are a diverse group of bioactive polyketides produced by dinoflagellates of the genus Amphidinium, known for their hemolytic, antifungal, and cytotoxic activities. This work presents the assessment of AM profiles in a comprehensive number of strains, whose species boundaries were [...] Read more.
Amphidinols (AM) are a diverse group of bioactive polyketides produced by dinoflagellates of the genus Amphidinium, known for their hemolytic, antifungal, and cytotoxic activities. This work presents the assessment of AM profiles in a comprehensive number of strains, whose species boundaries were previously established through detailed taxonomic analysis. Using UHPLC-MS/MS, we characterized the spectrum of AM analogs in 54 Amphidinium strains isolated from diverse geographical locations. In addition, toxicity was assessed using brine shrimp assays, which revealed significant inter- and intraspecific variability. Despite the broad diversity in AM content, no clear correlation was observed between total AM levels and toxicity across all strains. Multivariate analysis grouped the strains into clusters distinguished by distinct AM profiles and toxicity levels, suggesting that AM production alone does not predict toxicity. Our findings highlight the complexity of Amphidinium bioactivity, emphasizing the influence of strain-specific factors and other bioactive compounds. This work highlights the importance of integrating chemical, genetic, and biological assessments to understand better the factors that govern toxicity in this genus, with implications for ecological studies and the monitoring of harmful dinoflagellates. Full article
(This article belongs to the Special Issue Marine Biotoxins, 4th Edition)
Show Figures

Figure 1

Back to TopTop