Special Issue "Contribution of Cytolethal Distending Toxin to Diseases Caused by Clinically-important Bacterial Pathogens"
Deadline for manuscript submissions: closed (15 March 2016)
Prof. Dr. Gerald E. Duhamel
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
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Interests: comparative gastrointestinal pathology; development and assessment of animal models of intestinal disease and basic understanding of molecular mechanisms of host-pathogen interactions and their relationship to susceptibility and resistance against enteric diseases; microbial pathogenesis of enteropathogenic Campylobacter and Helicobacter bacterial species and mechanisms of cytolethal distending toxin-induced DNA damage response within the context of intestinal diseases of human and animals.
Cytolethal distending toxin (CDT) is a potent AB type genotoxin produced by more than 30 medically-important Gram-negative bacterial pathogens of the Gamma and Epsilon classes of Proteobacteria. Included amongst these bacteria are several pathotypes of Escherichia coli, certain species of Campylobacter, Helicobacter, and Shigella, and a clad of Salmonella enterica subsp. enterica serotypes that collectively are responsible for the majority of clinically-important food-borne and water-borne zoonotic intestinal illnesses worldwide. Moreover, members of the Haemophilus species associated with chronic genital infections and acute sepsis and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans a major periodontal disease pathogen also produce CDT; however, the contribution of CDT to microbial pathogenesis remains incompletely understood. Experimental studies to date have focused on mechanisms of CDT-induced eukaryotic cell genotoxicity in vitro and ex vivo, while few animal studies suggest a critical role for CDT in direct cell damage and resistance against host innate defense mechanisms. Alterations of host cell homeostasis likely contributes to infection and disease caused by CDT-producing bacterial pathogens, and thus, this Special Issue of Toxins will focus on molecular mechanisms of CDT-induced genotoxicity in the context of disease mechanisms. The goal is to increase our understanding of the contribution of this broadly-conserved genotoxin to mechanisms of infection and disease and provide a basis for development of control strategies for major bacterial pathogens of humans and animals.
Prof. Dr. Joseph M. DiRienzo
Prof. Dr. Gerald E. Duhamel
Manuscript Submission Information
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- cell cycle
- cytolethal distending toxin
- diarrheal disease
- enteric bacteria
- eukaryotic cell
- periodontal disease