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Dynamic Duo—The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin

Impact of CDT Toxin on Human Diseases

Microbes, Inflammation, Intestin et Susceptibilité de l’Hôte (M2iSH), Clermont Université, Université d’Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France
Institut Universitaire de Technologie, Université d’Auvergne, Aubière 63170, France
Authors to whom correspondence should be addressed.
Academic Editors: Joseph M. DiRienzo and Gerald E. Duhamel
Toxins 2016, 8(7), 220;
Received: 10 February 2016 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects. View Full-Text
Keywords: CDT toxin; CDT-producing bacteria; DNA damage CDT toxin; CDT-producing bacteria; DNA damage
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MDPI and ACS Style

Faïs, T.; Delmas, J.; Serres, A.; Bonnet, R.; Dalmasso, G. Impact of CDT Toxin on Human Diseases. Toxins 2016, 8, 220.

AMA Style

Faïs T, Delmas J, Serres A, Bonnet R, Dalmasso G. Impact of CDT Toxin on Human Diseases. Toxins. 2016; 8(7):220.

Chicago/Turabian Style

Faïs, Tiphanie, Julien Delmas, Arnaud Serres, Richard Bonnet, and Guillaume Dalmasso. 2016. "Impact of CDT Toxin on Human Diseases" Toxins 8, no. 7: 220.

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