Impact of CDT Toxin on Human Diseases
Tiphanie Faïs 1,2,3,*, Julien Delmas 1,2,3
, Arnaud Serres 2, Richard Bonnet 1,2,3 and Guillaume Dalmasso 1,2,3,*
, Arnaud Serres 2, Richard Bonnet 1,2,3 and Guillaume Dalmasso 1,2,3,*
1
Microbes, Inflammation, Intestin et Susceptibilité de l’Hôte (M2iSH), Clermont Université, Université d’Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France
2
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France
3
Institut Universitaire de Technologie, Université d’Auvergne, Aubière 63170, France
*
Authors to whom correspondence should be addressed.
Academic Editors: Joseph M. DiRienzo and Gerald E. Duhamel
Toxins 2016, 8(7), 220; https://doi.org/10.3390/toxins8070220
Received: 10 February 2016 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue Contribution of Cytolethal Distending Toxin to Diseases Caused by Clinically-important Bacterial Pathogens)
Abstract
Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects. View Full-TextKeywords:
CDT toxin; CDT-producing bacteria; DNA damage
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MDPI and ACS Style
Faïs, T.; Delmas, J.; Serres, A.; Bonnet, R.; Dalmasso, G. Impact of CDT Toxin on Human Diseases. Toxins 2016, 8, 220.
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