Treatment and Management of Uremic Toxins in Chronic Kidney Disease Patients
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 240
Special Issue Editors
Interests: chronic kidney disease; endothelial dysfunction; uremic toxins; dialysis; peritoneal dialysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is characterized by the progressive accumulation of uremic toxins, which play a central role in the development of systemic complications, including cardiovascular disease, chronic inflammation, metabolic dysfunction, mineral and bone disorders, and impaired quality of life. In recent years, experimental nephrology, particularly studies using in vitro and ex vivo models, has significantly advanced our understanding of the cellular and molecular mechanisms underlying uremic toxicity. These approaches have elucidated how individual toxins and complex toxin mixtures affect endothelial dysfunction, inflammatory signaling, oxidative stress, and inter-organ communication.
Despite these important mechanistic advances, the translation of experimental findings into effective clinical strategies for uremic toxin management remains a major challenge. Conventional dialysis techniques and currently available pharmacological approaches still fail to adequately remove many clinically relevant uremic toxins, particularly protein-bound and gut-derived solutes. Consequently, increasing attention has been directed toward translational strategies that integrate experimental models with clinical innovation. These include the development of novel extracorporeal and adsorptive techniques, the modulation of toxin generation and transport pathways, targeting the gut–kidney axis, and preventive interventions initiated at early stages of CKD.
In parallel, advanced in vitro models and analytical approaches continue to play a crucial role in identifying novel therapeutic targets and clinically meaningful biomarkers of uremic toxicity. This Special Issue will bring together experimental, translational, and clinical studies, as well as comprehensive review articles, that bridge mechanistic research and clinical practice in the management of uremic toxins.
Prof. Dr. Andréa Emilia Marques Stinghen
Dr. Fellype de Carvalho Barreto
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic kidney disease
- endothelial dysfunction
- uremic toxins
- experimental nephrology
- translational research
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
