Special Issue "Functional Genomics of Toxigenic Fungi and Regulatory Mechanism in the Biosynthesis of Mycotoxins"
Deadline for manuscript submissions: closed (30 June 2018).
The occurrence of fungal species, able to produce toxic metabolites, in agro-food products has received increasing attention over the last few decades. These metabolites, known as mycotoxins, are generally of low molecular weight, may have toxic activity toward plants, but they principally represent a serious risk for human and animal health. In the 1990s, fungal secondary metabolites (SMs), such as antibiotics and mycotoxins, started to be genetically characterized. In the pre-genomic era, the clustered arrangement of genes involved in the biosynthesis of a single SM was studied by means of cumbersome and traditional molecular methods. The breakthrough of next-generation sequencing (NGS) technologies, and the advent of Bioinformatics and Genomics, have revolutionized research on SM biosynthesis pathways. However, a great deal remains to be clarified in order to completely explain the pathway steps and the regulatory network behind metabolite biosynthesis. More recently, genomic, transcriptomic, proteomic, and metabolomic tools, applied to fungal biology, have provided new data for understanding the ecology of toxigenic fungi in the field and crops, and the process of mycotoxin production and contamination under various environmental conditions. These current technologies of functional genomics have the potential to reveal the molecular mechanisms of response to climate change, as well as abiotic regulation of the secondary metabolites production and influence on the plant–fungus interactions.
This Special Issue of Toxins wishes to present the most recent data on the main aspects of functional genomics of toxigenic fungi and regulatory mechanisms in the biosynthesis of mycotoxins, with the aim of better understanding the eco-physiology of mycotoxin production, and to get a view of predicting changes in fungal infections and toxin production associated with new climate scenarios.
Dr. Giancarlo Perrone
Dr. Antonia Gallo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mycotoxigenic fungi
- secondary metabolites
- fungal genomics
- fungal transcriptomics
- fungal metabolomics
- biosynthesis gene cluster
- regulatory pathway
- transcription factors
- stress induction
- signal transduction