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Special Issue "Mycolactone: Lipid-Like Immunosuppressive Toxin of Buruli Ulcer"
Deadline for manuscript submissions: closed (30 June 2019).
Prof. Dr. Gerd Pluschke
Head Molecular Immunology, Swiss Tropical Institute, 4052 Basel, Switzerland
Dr. Rachel Simmonds
Department of Microbial Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
Mycobacterium ulcerans is the causative agent of the neglected tropical skin disease, Buruli ulcer (BU). In BU lesions, extracellular clusters of acid-fast bacilli are found in completely necrotic subcutaneous fat tissue. Mycolactone, a polyketide lactone exotoxin is the major virulence factor of M. ulcerans and causes immunosuppression and apoptosis in mammalian cells. Several mammalian molecular targets for mycolactone have been proposed and their relative contributions to the different effects of mycolactone has remained controversial. However, genetic evidence has proven that the Sec61 translocon is a major molecular target of mycolactone and that Bim-dependent apoptosis is crucial for the chronic necrotizing nature of BU. The Sec61 translocon is a molecular machine at the ER membrane with an essential role in the export of many secretory and membrane proteins. Translocation blockade seems to play a key role in mycolactone-mediated immunosuppression and cell death. Mycolactone specific antibodies have been shown to neutralize the toxic activity of mycolactone and may have potential for diagnostic assay development and immune prophylaxis.
The aim of this Special Issue is to draw together the recent advances in our understanding of mycolactone activity and how this impacts BU pathogenesis. Moreover, this Special Issue wishes to highlight the broader implications of mycolactone’s biological activity, with applications in other areas, such as the understanding of translocation biology, cell death pathways and neuroinflammation. We invite original research papers, reviews, short communications, commentaries, and letters to the editor on any topic related to mycolactone including:
- Discovery of mycolactone
- Buruli ulcer pathogenesis
- Anti-inflammatory and immunosuppressive activity
- Mycolactone and coagulation control/endothelial dysfunction
- Effect on neurons and analgesic properties
- Mechanisms of cell death
- Biochemistry of translocation inhibition
- Potential role of mycolactone in Buruli ulcer transmission
- Enzymology and genetics of mycolactone production by M. ulcerans
- Immunology of mycolactone and implications for tool development
- Mycolactone, BU diagnosis and monitoring of treatment
- Chemistry/synthesis of mycolactones
- Biophysical properties of mycolactone
Prof. Dr. Gerd Pluschke
Dr. Rachel Simmonds
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Mycobacterium ulcerans
- Buruli ulcer
- Protein Translocation
- Molecular mechanisms
- Polyketide synthases