Research on Botulinum Toxin for Urinary System Diseases and Pelvic Pain
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 3620
Special Issue Editors
Interests: neuro-urology; functional urology
Special Issue Information
Dear Colleagues,
The main medical innovation in recent years in neurogenic detrusor overactivity (NDO) and overactive bladder (OAB) has been the approval of intradetrusor onabotulinum toxin A.
While onabotulinum toxin A has been approved by FDA and EMA in 2011 for NDO and in 2014 for OAB, recent phase 2 RCTs have suggested that intradetrusor injections of botulinum toxin may also be effective in improving bladder pain syndrome/interstitial cystitis (BPS/IC), likely by reducing central and peripheral nerve sensitization, decreasing noxious neurotransmitter release, and targeting neurogenic inflammation. Despite the mainstream use of BonTA worldwide in treating NDO and OAB as well as BPS and/IC, the exact mechanisms of action are not fully understood. Moreover, there is still a lack in definition of failure of botulinum toxin intra-detrusor injections for NDO. There is still also a need to find a universal consensus for the management of NDO refractory to botulinum toxin.
There is also emerging evidence that in some neurogenic populations with NDO, that are non-using or not willing to have intermittent catheterization like multiple sclerosis or Parkinson patients, the ideal applied doses might not be the same as in other neurogenic populations, like SCI patients.
At least there are emerging indications on the use of botulinum toxin in urology-like refractory erectile dysfunction.
The aim of this Special Issue is to present a collection of articles by pioneers in the actual knowledge on the use of botulinum toxin in urology, known and possible mechanisms of action, and to describe their trials and drawbacks. This Special Issue also aims to describe the use of other botulinum toxin A and new developments in the administration route of the urological field.
Topics of interest include (but are not limited to):
- Mechanism of action in OAB, NDO, BPS/IC
- Therapy failure
- New indication
- New route of administration
We look forward to receiving your contributions.
Prof. Brigitte Schurch
Prof. Dr. Pierre Denys
Guest Editors
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Keywords
- onabotulinum toxin
- abobotulinum toxin
- mechanisms of action
- NDO
- OAB
- BPS/IC
- therapy failure
- multiple sclerosis
- Parkinson
- erectile dysfunction
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