Special Issue "Research on Botulinum Toxin for Urinary System Diseases and Pelvic Pain"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Brigitte Schurch
E-Mail Website
Guest Editor
Neuro-urology unit, Department of Neuroscience, University Hospital Lausanne, UNIL, Lausanne Suisse
Interests: neuro-urology; functional urology
Prof. Dr. Pierre Denys
E-Mail Website
Guest Editor
Neuro-Urology and Andrology Unit, Department of Physical Medecine and Rehabilitation, Hôpital Raymond Poincaré, APHP, Université Paris Saclay, Garches, France

Special Issue Information

Dear Colleagues,

The main medical innovation in recent years in neurogenic detrusor overactivity (NDO) and overactive bladder (OAB) has been the approval of intradetrusor onabotulinum toxin A.

While onabotulinum toxin A has been approved by FDA and EMA in 2011 for NDO and in 2014 for OAB, recent phase 2 RCTs have suggested that intradetrusor injections of botulinum toxin may also be effective in improving bladder pain syndrome/interstitial cystitis (BPS/IC), likely by reducing central and peripheral nerve sensitization, decreasing noxious neurotransmitter release, and targeting neurogenic inflammation. Despite the mainstream use of BonTA worldwide in treating NDO and OAB as well as BPS and/IC, the exact mechanisms of action are not fully understood. Moreover, there is still a lack in definition of failure of botulinum toxin intra-detrusor injections for NDO. There is still also a need to find a universal consensus for the management of NDO refractory to botulinum toxin.

There is also emerging evidence that in some neurogenic populations with NDO, that are non-using or not willing to have intermittent catheterization like multiple sclerosis or Parkinson patients, the ideal applied doses might not be the same as in other neurogenic populations, like SCI patients.

At least there are emerging indications on the use of botulinum toxin in urology-like refractory erectile dysfunction.

The aim of this Special Issue is to present a collection of articles by pioneers in the actual knowledge on the use of botulinum toxin in urology, known and possible mechanisms of action, and to describe their trials and drawbacks. This Special Issue also aims to describe the use of other botulinum toxin A and new developments in the administration route of the urological field.

Topics of interest include (but are not limited to):

  • Mechanism of action in OAB, NDO, BPS/IC
  • Therapy failure
  • New indication
  • New route of administration

We look forward to receiving your contributions.

Prof. Brigitte Schurch
Prof. Dr. Pierre Denys
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • onabotulinum toxin
  • abobotulinum toxin
  • mechanisms of action
  • NDO
  • OAB
  • BPS/IC
  • therapy failure
  • multiple sclerosis
  • Parkinson
  • erectile dysfunction

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Botulinum toxin and MS : witch dose for witch patient
Authors: Brigitte Schurch
Affiliation: Neuro-urology unit, Department of Neuroscience, University Hospital Lausanne, UNIL, Lausanne Suisse

Title: Botulinum toxin and OAB
Authors: Victor nitti
Affiliation: Departments of Urology and Obstetrics & Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Title: Botulinum toxin and NDO : is there is any difference from one drug to the other
Authors: Michael J. Kennelly
Affiliation: Carolinas Rehabilitation - Urology, 1100 Blythe Blvd., Charlotte, NC 28203

Title: Botulinum toxin and BPS
Authors: David Castro-Diaz
Affiliation: University Hospital of the Canary Islands (Spain)

Title: Botulinum toxin and refractory erectile dysfunction : effect of Xeomin 100 U
Authors: Pierre Denys; Fran4ois Giulinao
Affiliation: Unité de neuro-urologie, service de médecine physique et de réadaptation, hôpital Raymond-Poincaré, AP–HP, université Versailles – Saint-Quentin, 104, boulevard Raymond-Poincaré, 92380 Garches, France

Title: Systematic review on secondary therapeutic failure
Authors: Charles Joussain
Affiliation: Centre Hospitalier Universitaire de Dijon · Centre de Rééducation et de Convalescence

Title: Botulinum toxin and erectile dysfunction : mode of action in animals
Authors: Francois Giuliano
Affiliation: Universite Paris-Saclay, Saint-Aubin, France

Title: The influence of voiding conditions on the therapeutic efficacy and satisfaction to detrusor botulinum toxin A injections in patients with chronic spinal cord injury and detrusor overactivity
Authors: Hann-Chorng Kuo
Affiliation: Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan

Title: Patient's satisfaction and predictive factors of urethral sphincter botulinum toxin A injections for patients with chronic spinal cord injury and detrusor sphincter dyssynergia.
Authors: Hann-Chorng Kuo
Affiliation: Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University Hualien, Taiwan

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