Special Issue "Bacterial Exotoxins and Their Impact on Host–Pathogen Interaction in Animals and Humans"
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 13280
Interests: pathogenesis and pathology of bacterial infections; host-pathogen interaction; bacterial exotoxins; pore-forming toxins; clostridium perfringens toxins
Bacterial infections are a threat to human and animal health worldwide. In light of the increasing problem of antibiotic resistance, alternative treatments are needed. Understanding the mechanisms underlying host–pathogen interactions is crucial for the development of such alternative approaches. Many bacterial pathogens manipulate host cells and tissues via secreted toxins. A plethora of toxins targeting different cellular structures and functions has thus evolved. Toxic attacks on host cells come in many different flavors, ranging from an attack of the plasma membrane via a secreted enzyme to the internalization of multifunctional protein complexes that specifically target intracellular structures or pathways. In-depth knowledge about the mechanisms of how such specified toxins manipulate not only cellular, but also organ and body functions is central for our understanding of the pathogenesis of animal and human bacterial infections. Likewise, the host's cellular and systemic reactions to such "toxin attacks" contribute to disease and must be considered for the design of alternative treatments.
This Special Issue will focus on mechanisms of toxicity exploited by bacterial exotoxins, their effects on target cells and whole organisms as well as host reactions and defense mechanisms in response to these toxic effects. Original research articles, communications or reviews focused on these bacterial exotoxin–host interactions in animal and human disease are welcome.
Prof. Horst Posthaus
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bacterial exotoxins
- bacterial pathogens
- host–pathogen interaction
- cellular toxicity
- cell defense mechanisms
- systemic effects