Biological and Pharmacological Properties of Botulinum Neurotoxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 414
Special Issue Editor
Interests: movement disorders; Parkinson’s disease; ataxia; botulinum toxin; deep brain stimulation; medical education; clinical neurophysiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In light of the recent approval of a fifth botulinum neurotoxin (BoNT) brand in the United States and the introduction and development of several others around the world, there has been growing interest in furthering the knowledge of toxin serotypes and brand-specific biological and pharmacological properties. This is especially relevant considering the growing momentum of marketing claims of unique biological properties that distinguish brands from one another. Properties such as the precise mechanisms of action, diffusion, spread, and migration of BoNTs are of particular interest.
A little over a decade ago, a seminal review, the first of its kind, addressed the importance of this topic1, and in the decade that followed, it has become clear that more work is needed to address this important area of study. A recent update to the original review2 revealed that a substantial body of work has been carried out since, prompting greater research efforts in this particular field of study. Hence, we decided to update and expand on our previous work, devoting a Special Issue specifically to the biological and pharmacological properties of botulinum neurotoxins.
Submissions on the following topics are welcome:
- The biochemical and physical properties of BoNTs in human applications;
- The presence and future of designed BoNT libraries;
- An update on diffusion, spread, and migration of BoNTs;
- The potential impact of injected tissue on BoNTs’ behavior;
- A review and analysis of clinical evidence;
- Priorities and strategies for future BoNT research efforts;
- Other clinical applications of BoNTs.
References:
- Ramirez-Castaneda J, Jankovic J, Comella C, Dashtipour K, Fernandez HH, Mari Z. Diffusion, spread, and migration of botulinum toxin. Mov Disord. 2013 Nov;28(13):1775-83. doi: 10.1002/mds.25582. Epub 2013 Jul 18. PMID: 23868503
- Mari Z. Diffusion, Spread, and Migration of Botulinum Toxin: An Update. TOXICON Volume 214, Supplement 1, Page S66, ISSN 0041-0101, 2022
Dr. Zoltan Mari
Guest Editor
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Keywords
- botulinum neurotoxins
- biochemical and physical properties
- clinical applications
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