Special Issue "Chemical and Biological Threats, Hazard Potential and Countermeasures"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Dr. Ondrej Soukup
E-Mail Website
Guest Editor
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic
Interests: organophosphate poisoning; nerve agents; oxime reactivators; toxicology; military pharmacy; drug delivery Alzheimer’s disease; acetylcholinesterase; butyrylcholinesterase; cholinesterase; drug development;; in vitro testing; in vivo; toxicokinetics
Special Issues and Collections in MDPI journals
Dr. Jan Korabecny
E-Mail Website
Guest Editor
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic
Interests: Alzheimer’s disease; acetylcholinesterase; butyrylcholinesterase; cholinesterase; drug development; organic synthesis; medicinal chemistry; organophosphate poisoning; nerve agents; oxime reactivators; toxicology; military pharmacy; in silico methods
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

We have issued the Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures.

We would like to encourage our colleagues from this field for the submission of review or original research articles that encompasses this field at different levels including chemical, biological, medical and epidemiological approaches.

 

Dr. Ondrej Soukup
Dr. Jan Korabecny
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical warfare agent
  • organophosphorus compound
  • biological agent
  • nerve agents
  • novichoks
  • safety and health
  • intoxication
  • protection
  • decontamination
  • hazard potential
  • antidote
  • countermeasure

Published Papers (1 paper)

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Research

Article
Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
Toxics 2021, 9(9), 222; https://doi.org/10.3390/toxics9090222 - 15 Sep 2021
Viewed by 395
Abstract
Benzoxonium chloride belongs to the group of quaternary ammonium salts, which have been widely used for decades as disinfectants because of their high efficacy, low toxicity, and thermal stability. In this study, we have prepared the C10-C18 set of benzoxonium-like [...] Read more.
Benzoxonium chloride belongs to the group of quaternary ammonium salts, which have been widely used for decades as disinfectants because of their high efficacy, low toxicity, and thermal stability. In this study, we have prepared the C10-C18 set of benzoxonium-like salts to evaluate the effect of their chemical and biological decontamination capabilities. In particular, biocidal activity against a panel of bacterial strains including Staphylococcus aureus in biofilm form was screened. In addition, the most promising compounds were successfully tested against Francisella tularensis as a representative of potential biological warfare agents. From a point of view of chemical warfare protection, the efficiency of BOC-like compounds to degrade the organophosphate simulant fenitrothion was examined. Notwithstanding that no single compound with universal effectiveness was identified, a mixture of only two compounds from this group would be able to satisfactorily cover the proposed decontamination spectrum. In addition, the compounds were evaluated for their cytotoxicity as a basic safety parameter for potential use in practice. In summary, the dual effect on chemical and biological agents of benzoxonium-like salts offer attractive potential as active components of decontamination mixtures in the case of a terrorist threat or chemical or biological accidents. Full article
(This article belongs to the Special Issue Chemical and Biological Threats, Hazard Potential and Countermeasures)
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