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Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts

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Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
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Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic
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Department of Epidemiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic
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Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Eduardo Rocha
Toxics 2021, 9(9), 222; https://doi.org/10.3390/toxics9090222
Received: 28 July 2021 / Revised: 2 September 2021 / Accepted: 4 September 2021 / Published: 15 September 2021
(This article belongs to the Special Issue Chemical and Biological Threats, Hazard Potential and Countermeasures)
Benzoxonium chloride belongs to the group of quaternary ammonium salts, which have been widely used for decades as disinfectants because of their high efficacy, low toxicity, and thermal stability. In this study, we have prepared the C10-C18 set of benzoxonium-like salts to evaluate the effect of their chemical and biological decontamination capabilities. In particular, biocidal activity against a panel of bacterial strains including Staphylococcus aureus in biofilm form was screened. In addition, the most promising compounds were successfully tested against Francisella tularensis as a representative of potential biological warfare agents. From a point of view of chemical warfare protection, the efficiency of BOC-like compounds to degrade the organophosphate simulant fenitrothion was examined. Notwithstanding that no single compound with universal effectiveness was identified, a mixture of only two compounds from this group would be able to satisfactorily cover the proposed decontamination spectrum. In addition, the compounds were evaluated for their cytotoxicity as a basic safety parameter for potential use in practice. In summary, the dual effect on chemical and biological agents of benzoxonium-like salts offer attractive potential as active components of decontamination mixtures in the case of a terrorist threat or chemical or biological accidents. View Full-Text
Keywords: quaternary ammonium salts; benzoxonium; decontamination; organophosphates; disinfection; micellar catalysis quaternary ammonium salts; benzoxonium; decontamination; organophosphates; disinfection; micellar catalysis
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MDPI and ACS Style

Markova, A.; Hympanova, M.; Matula, M.; Prchal, L.; Sleha, R.; Benkova, M.; Pulkrabkova, L.; Soukup, O.; Krocova, Z.; Jun, D.; Marek, J. Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts. Toxics 2021, 9, 222. https://doi.org/10.3390/toxics9090222

AMA Style

Markova A, Hympanova M, Matula M, Prchal L, Sleha R, Benkova M, Pulkrabkova L, Soukup O, Krocova Z, Jun D, Marek J. Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts. Toxics. 2021; 9(9):222. https://doi.org/10.3390/toxics9090222

Chicago/Turabian Style

Markova, Aneta, Michaela Hympanova, Marek Matula, Lukas Prchal, Radek Sleha, Marketa Benkova, Lenka Pulkrabkova, Ondrej Soukup, Zuzana Krocova, Daniel Jun, and Jan Marek. 2021. "Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts" Toxics 9, no. 9: 222. https://doi.org/10.3390/toxics9090222

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