Special Issue "Toxicity of Chemical Mixtures"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 31 January 2019

Special Issue Editor

Guest Editor
Prof. Jennifer L. Freeman

School of Health Sciences, Purdue University, West Lafayette, IN, USA
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Special Issue Information

Dear Colleagues,

In our everyday environment, we are exposed to a number of different chemical agents. However, the majority of toxicity studies involve only a single chemical presenting difficulties in chemical risk assessment. Over the past few decades, there has been a growing emphasis on studies that address various scientific questions in the evaluation of the toxicity of chemicals in a mixture. These studies are clarifying our understanding of potential toxic interactions ocurring when chemicals are present in a mixture and defining non-interactive or interactive mechanisms, including synergistic, potentiative, and antagonist interactions.

This Special Issue will focus on highlighting timely research studies addressing the toxicity of chemical mixtures. Topics are expected to include any chemical agent mixtures covering a broad base of scientific questions related to the toxicity of chemical mixtures. Studies may include, but are not limited to assessments of toxicokinetic, toxicodynamic, or metabolism interactions; molecular or epigenetic mechanisms of toxicity; phenotypic or behavioral outcomes; and/or predictive or computational toxicology approaches. Authors are invited and welcome to submit original research papers, reviews, and short communications. 

Prof. Jennifer L. Freeman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antagonism
  • Endocrine disrupting chemicals
  • Flame retardants
  • Metals
  • Mixtures
  • Pesticides
  • Pharmaceuticals
  • Persistent Organic Pollutants
  • Potentiation
  • Synergism

Published Papers (1 paper)

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Research

Open AccessArticle Evaluating the Joint Toxicity of Two Benzophenone-Type UV Filters on the Green Alga Chlamydomonas reinhardtii with Response Surface Methodology
Received: 24 October 2017 / Revised: 8 January 2018 / Accepted: 9 January 2018 / Published: 10 January 2018
Cited by 1 | PDF Full-text (1808 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The widespread occurrence of benzophenone-type ultraviolet (UV) filter has raised the public concerns over the ecotoxicological effects of these chemicals. The present study assessed the joint toxicity of two representative benzophenones, benzophenone-1 (BP-1) and benzophenone-3 (BP-3), on the green alga Chlamydomonas reinhardtii using
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The widespread occurrence of benzophenone-type ultraviolet (UV) filter has raised the public concerns over the ecotoxicological effects of these chemicals. The present study assessed the joint toxicity of two representative benzophenones, benzophenone-1 (BP-1) and benzophenone-3 (BP-3), on the green alga Chlamydomonas reinhardtii using response surface methodologies (RSM). Specific growth rate and photosynthetic pigments were used as endpoints to evaluate the toxic effects. Generally, exposure to the combined BP-1 and BP-3 negatively affected cell growth and pigments production, with higher inhibitions at higher exposure concentrations. The simultaneous reduction in growth rate and pigments contents indicated that BP-1 and BP-3 regulated the growth of the tested alga by affecting the photosynthesis process. Results also showed that second order polynomial regression models fitted well with experimental results for all endpoints. The obtained regression models further indicated that the effects of the combination stemmed significantly from the linear concentration of BP-1 and BP-3. The overall results demonstrated that RSM could be a useful tool in ecotoxicological studies. Full article
(This article belongs to the Special Issue Toxicity of Chemical Mixtures)
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