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Open AccessArticle

Comparison of the Respiratory Toxicity and Total Cholinesterase Activities in Dimethyl Versus Diethyl Paraoxon-Poisoned Rats

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Laboratoire de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France
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Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), CNRS UMR8258-U1022, Faculté de Pharmacie Paris Descartes, Université Paris Descartes, 75006 Paris, France
3
Département d’Anesthésie–Réanimation-SAMU de Paris, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France
4
EA7323 Evaluation of Therapeutics and Pharmacology in Perinatality and Pediatrics-Hôpitaux Universitaires Cochin–Broca–Hôtel Dieu, Site Tarnier, Université Paris Descartes, 75006 Paris, France
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Université Paris Diderot, 75013 Paris, France
*
Author to whom correspondence should be addressed.
Toxics 2019, 7(2), 23; https://doi.org/10.3390/toxics7020023
Received: 26 February 2019 / Revised: 11 April 2019 / Accepted: 13 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Toxicity of Chemical Mixtures)
The chemical structure of organophosphate compounds (OPs) is a well-known factor which modifies the acute toxicity of these compounds. We compared ventilation at rest and cholinesterase activities in male Sprague-Dawley rats poisoned with dimethyl paraoxon (DMPO) and diethyl paraoxon (DEPO) at a subcutaneous dose corresponding to 50% of the median lethal dose (MLD). Ventilation at rest was recorded by whole body plethysmography. Total cholinesterase activities were determined by radiometric assay. Both organophosphates decreased significantly the respiratory rate, resulting from an increase in expiratory time. Dimethyl-induced respiratory toxicity spontaneously reversed within 120 min post-injection. Diethyl-induced respiratory toxicity was long-lasting, more than 180 min post-injection. Both organophosphates decreased cholinesterase activities from 10 to 180 min post-injection with the same degree of inhibition of total cholinesterase within an onset at the same times after injection. There were no significant differences in residual cholinesterase activities between dimethyl and diethyl paraoxon groups at any time. The structure of the alkoxy-group is a determinant factor of the late phase of poisoning, conditioning duration of toxicity without significant effects on the magnitude of alteration of respiratory parameters. For same duration and magnitude of cholinesterase inhibition, there was a strong discrepancy in the time-course of effects between the two compounds. View Full-Text
Keywords: dimethyl paraoxon; diethyl paraoxon; rats; plethysmography; respiratory toxicity; cholinesterases dimethyl paraoxon; diethyl paraoxon; rats; plethysmography; respiratory toxicity; cholinesterases
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Houzé, P.; Hutin, A.; Lejay, M.; Baud, F.J. Comparison of the Respiratory Toxicity and Total Cholinesterase Activities in Dimethyl Versus Diethyl Paraoxon-Poisoned Rats. Toxics 2019, 7, 23.

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