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Separations
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Capillary and Microchip Electrophoresis for Bioanalysis
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Capillary and Microchip Electrophoresis for Bioanalysis

A special issue of Separations (ISSN 2297-8739).

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 8019

Special Issue Editor

Dr. Marián Masár

E-Mail Website1 Website2
Guest Editor
Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, SK-84215 Bratislava, Slovakia
Interests: capillary and microchip electrophoresis; lab-on-a-chip; online sample pretreatment; hyphenated electroseparation techniques; green analytical chemistry; pharmaceutical analysis; bioanalysis

Special Issue Information

Dear Colleagues,

The use of capillary electrophoresis (CE) for the analysis of complex biological samples has significantly increased over the past several years. Moreover, a miniaturized version of CE, microchip electrophoresis (MCE), has also found a broad applicability in bioanalysis because of high-speed and high-throughput analysis with high separation efficiency; reduced consumption of solvents; and production of waste, easy automation, and low running costs.

This Special Issue is intended to present the state of the art in CE/MCE techniques performed from preparative to analytical scale and used for analysis of biological samples.

Suggested topics include improvements in bioanalysis in terms of CE/MCE instrumentation, methodological developments, and electrophoretic sample preparation techniques. CE/MCE applications focused on analytes of biological origin, e.g., nucleic acids, proteins, peptides, metabolites, pharmaceuticals, or single cells, are also welcome in this Issue.

Dr. Marián Masár
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Capillary electrophoresis
  • Microchip electrophoresis
  • Bioanalysis
  • Biological samples
  • Sample preparation
  • Metabolites
  • Pharmaceuticals
  • Biomolecules

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Published Papers (2 papers)

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Research

9 pages, 1577 KiB  
Article
Rapid Production of PDMS Microdevices for Electrodriven Separations and Microfluidics by 3D-Printed Scaffold Removal
by Alena Šustková, Klára Konderlová, Ester Drastíková, Stefan Sützl, Lenka Hárendarčíková and Jan Petr
Separations 2021, 8(5), 67; https://doi.org/10.3390/separations8050067 - 14 May 2021
Cited by 1 | Viewed by 3189
Abstract
In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were [...] Read more.
In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were fully inserted in the PDMS and then carefully removed. The bonded devices were produced by forming imprints of the 3D-printed scaffolds in PDMS, followed by bonding the PDMS parts to glass slides. All these microfluidic devices were then successfully employed in three proof-of-concept applications: capture of magnetic microparticles, formation of droplets, and isotachophoresis separation of model organic dyes. Full article
(This article belongs to the Special Issue Capillary and Microchip Electrophoresis for Bioanalysis)
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13 pages, 1013 KiB  
Article
Determination of Carminic Acid in Foodstuffs and Pharmaceuticals by Microchip Electrophoresis with Photometric Detection
by Marián Masár, Jasna Hradski, Eva Vargová, Adriána Miškovčíková, Peter Božek, Juraj Ševčík and Roman Szucs
Separations 2020, 7(4), 72; https://doi.org/10.3390/separations7040072 - 13 Dec 2020
Cited by 13 | Viewed by 4044
Abstract
This paper presents a novel miniaturized analytical method for the determination of carminic acid, a natural red food dye, in complex food and pharmaceutical matrices by microchip electrophoresis (MCE) with photometric detection. MCE has become a very attractive microscale separation technique because it [...] Read more.
This paper presents a novel miniaturized analytical method for the determination of carminic acid, a natural red food dye, in complex food and pharmaceutical matrices by microchip electrophoresis (MCE) with photometric detection. MCE has become a very attractive microscale separation technique because it offers high-speed, high-throughput, small sample injection volume and low reagents consumption. Fast determination of carminic acid in less than 5 min was achieved on a poly(methyl methacrylate) microchip in anionic separation mode at pH 6. Photometric detector based on light-emitting diode technology was set to a wavelength of 490 nm. Using a sample injection volume of 900 nL, a limit of detection of 69 nmol L−1 was achieved. A wide linear dynamic range over four orders of magnitude (from nmol L−1 to mmol L−1) was observed for peak area. Developed method provided favorable intra- and inter-day repeatability of the migration time (up to 2.5% RSD), as well as the repeatability of the peak area (less than 1.9% RSD), regardless of the sample type. The content of carminic acid was determined in various foodstuffs and pharmaceuticals, such as candies, saffron, non-alcoholic drink, and sore throat lozenges with good recoveries (92.5–104.0%). Full article
(This article belongs to the Special Issue Capillary and Microchip Electrophoresis for Bioanalysis)
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