Extraction and Characterization of Phenolic Compounds from Foods and Food Byproducts by Targeted and Untargeted LC-MS Methods

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 122

Special Issue Editors

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Guest Editor
Department of Food Science and Technology at the University of West Attica, Athens, Greece
Interests: food byproducts; non-conventional extraction techniques; targeted and untargeted LC-MS methods; phytochemical profile of food samples/extracts; bioanalysis; metabolomic studies
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instrumental Food Analysis, Laboratory of Chemistry, Analysis & Design of Food Processes, Department of Food Science and Technology, Food Sciences School, University of West Attica, 12210 Egaleo, Greece
Interests: instrumental food analysis (chromatography, mass spectrometry, spectroscopy) analytical methods development; natural antioxidants extraction from agricultural side-streams; biomolecular structure identification; organoleptic properties (color and texture) measurement; image analysis of foods; chemometrics and application of statistical analysis for the classification and monitoring of the nutritional value of food products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue delves into the cutting-edge advancements in the application of Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) and non-conventional innovative extraction techniques for the recovery and characterization of phenolic compounds. Phenolic compounds, widely distributed in plants, play a pivotal role in various biological activities and are of significant interest in fields ranging from food processing and agri-food side streams to nutrition and medicine.

The collection of articles within this Special Issue spans diverse topics, including innovative extraction techniques, method development for comprehensive phenolic compound analysis/phenolic profiles of the extracts and the elucidation of the biological roles and health implications of these compounds.

The key themes covered in this Special Issue include:

  1. Methodological Advances: The Special Issue showcases novel methodologies for extracting phenolic compounds from complex matrices, focusing on optimizing sample preparation techniques and instrument parameters to enhance sensitivity and selectivity.
  2. Analytical Techniques: Articles explore the use of LC-MS/MS as a powerful analytical tool, emphasizing its capabilities in separating and detecting phenolic compounds with high precision and accuracy and/or mapping the phenolic fingerprint of the extracts using non-targeted LC-MS methods and multivariate statistical analysis tools. Topics include chromatographic column selection, mass spectrometry parameters, and method validation.
  3. Biological Significance: The Special Issue addresses the biological relevance of phenolic compounds, examining their potential therapeutic applications, antioxidant properties, and impact on human health.

Overall, this Special Issue serves as a comprehensive resource for researchers, analysts, and professionals interested in the latest developments and applications of extraction techniques and LC-MS/MS in the characterization of phenolic compounds, fostering a deeper understanding of their significance in diverse fields.'

Dr. Thalia Tsiaka
Prof. Dr. Vassilia J. Sinanoglou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • phenolic compounds
  • phenolic profile/fingerprint of natural extracts
  • non-conventional extraction techniques
  • food samples/food byproducts
  • phenolic compounds-Human health
  • targeted LC-MS methods
  • untargeted LC-MS methods

Published Papers

This special issue is now open for submission.
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