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Special Issue "Sensors and NanoSensors for Biomedical, Environmental and Food Monitoring Applications"

A special issue of Sensors (ISSN 1424-8220).

Deadline for manuscript submissions: 31 December 2018

Special Issue Editor

Guest Editor
Prof. Dr. Monica Florescu

Transilvania University of Brasov, Faculty of Medicine, Brasov, Romania
Website | E-Mail
Interests: biophysics; electrochemical and optical nanosensors/nanobiosensors for medical applications; biomolecular interactions

Special Issue Information

Dear Colleagues,

Sensors and biosensors based on different detection methods (electric, electrochemical, optical, piezoelectric, thermal or even atomic and nuclear) have earned considerable interest in recent years, and they show great promise for a wide range of applications in biological research, medical analysis and diagnostics, environmental and food industry monitoring. Making use of the synergetic effects between nanotechnology, biomolecules, and different detection methods has enabled nano(bio)sensors development for faster detection and its reproducibility in a much better way.

We invite, for this “Sensors and NanoSensors for Biomedical, Environmental and Food Monitoring Applications” Special Issue, manuscripts dealing with different detection method-based sensors for the application fields mentioned above, while not being limited to these presented in the frame of the International Conference IC-ANMBES 2018, held in Brasov, Romania (https://sciforum.net/conference/icanmbes2018). Both original research and review articles are welcome.

Original research papers that describe the development, characterization/evaluation, simulations and utilization of different architecture (sensor, fixed, mobile) platforms for the detection of both (bio)physical signals and biological active or toxic compounds in complex samples with potential applications in medical analysis and diagnosis, environmental and food industry monitoring are of interest. The manuscripts can deal with the following topics (but are not limited to) with potential relevance to sensory detection:

  • physical detectors for (bio)signals,
  • microfluidics and point-of-care microdevices,
  • optical fibers,
  • mass-sensitive chips,
  • novel materials electrodes and surface functionalization strategies applications or
  • new concepts and fundamental studies.

Reviews should provide an up-to-date and critical overview of state-of-the-art of platforms and detection mechanisms, especially those used for (bio)sensing and nano(bio)sensing.

Please feel free to contact us and send us your suggestions that you would like to discuss beforehand. We look forward to and welcome your participation in this Special Issue.

Prof. Dr. Monica Florescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Sensors
  • Nanosensors
  • Microfluidics
  • Point-of-care microdevices
  • Novel materials
  • Surface functionalization
  • Medical physics

Published Papers (3 papers)

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Research

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Open AccessArticle Designing Efficient Low-Cost Paper-Based Sensing Plasmonic Nanoplatforms
Sensors 2018, 18(9), 3035; https://doi.org/10.3390/s18093035
Received: 12 August 2018 / Revised: 6 September 2018 / Accepted: 8 September 2018 / Published: 11 September 2018
PDF Full-text (2343 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Paper-based platforms can be a promising choice as portable sensors due to their low-cost and facile fabrication, ease of use, high sensitivity, specificity and flexibility. By combining the qualities of these 3D platforms with the optical properties of gold nanoparticles, it is possible
[...] Read more.
Paper-based platforms can be a promising choice as portable sensors due to their low-cost and facile fabrication, ease of use, high sensitivity, specificity and flexibility. By combining the qualities of these 3D platforms with the optical properties of gold nanoparticles, it is possible to create efficient nanodevices with desired biosensing functionalities. In this work, we propose a new plasmonic paper-based dual localized surface plasmon resonance–surface-enhanced Raman scattering (LSPR-SERS) nanoplatform with improved detection abilities in terms of high sensitivity, uniformity and reproducibility. Specifically, colloidal gold nanorods (GNRs) with a well-controlled plasmonic response were firstly synthesized and validated as efficient dual LSPR-SERS nanosensors in solution using the p-aminothiophenol (p-ATP) analyte. GNRs were then efficiently immobilized onto the paper via the immersion approach, thus obtaining plasmonic nanoplatforms with a modulated LSPR response. The successful deposition of the nanoparticles onto the cellulose fibers was confirmed by LSPR measurements, which demonstrate the preserved plasmonic response after immobilization, as well as by dark-field microscopy and scanning electron microscopy investigations, which confirm their uniform distribution. Finally, a limit of detection for p-ATP as low as 10−12 M has been achieved by our developed SERS-based paper nanoplatform, proving that our optimized plasmonic paper-based biosensing design could be further considered as an excellent candidate for miniaturized biomedical applications. Full article
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Graphical abstract

Open AccessArticle Immunogold Nanoparticles for Rapid Plasmonic Detection of C. sakazakii
Sensors 2018, 18(7), 2028; https://doi.org/10.3390/s18072028
Received: 28 April 2018 / Revised: 12 June 2018 / Accepted: 19 June 2018 / Published: 25 June 2018
PDF Full-text (1316 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Cronobacter sakazakii is a foodborne pathogen that can cause a rare, septicemia, life-threatening meningitis, and necrotizing enterocolitis in infants. In general, standard methods for pathogen detection rely on culture, plating, colony counting and polymerase chain reaction DNA-sequencing for identification, which are time, equipment
[...] Read more.
Cronobacter sakazakii is a foodborne pathogen that can cause a rare, septicemia, life-threatening meningitis, and necrotizing enterocolitis in infants. In general, standard methods for pathogen detection rely on culture, plating, colony counting and polymerase chain reaction DNA-sequencing for identification, which are time, equipment and skill demanding. Recently, nanoparticle- and surface-based immunoassays have increasingly been explored for pathogen detection. We investigate the functionalization of gold nanoparticles optimized for irreversible and specific binding to C. sakazakii and their use for spectroscopic detection of the pathogen. We demonstrate how 40-nm gold nanoparticles grafted with a poly(ethylene glycol) brush and functionalized with polyclonal antibodies raised against C. sakazakii can be used to specifically target C. sakazakii. The strong extinction peak of the Au nanoparticle plasmon polariton resonance in the optical range is used as a label for detection of the pathogens. Individual binding of the nanoparticles to the C. sakazakii surface is also verified by transmission electron microscopy. We show that a high degree of surface functionalization with anti-C. sakazakii optimizes the detection and leads to a detection limit as low as 10 CFU/mL within 2 h using a simple cuvette-based UV-Vis spectrometric readout that has great potential for further optimization. Full article
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Graphical abstract

Review

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Open AccessReview Recent Developments in Enzyme, DNA and Immuno-Based Biosensors
Sensors 2018, 18(6), 1924; https://doi.org/10.3390/s18061924
Received: 4 May 2018 / Revised: 31 May 2018 / Accepted: 9 June 2018 / Published: 13 June 2018
Cited by 1 | PDF Full-text (1504 KB) | HTML Full-text | XML Full-text
Abstract
Novel sensitive, rapid and economical biosensors are being developed in a wide range of medical environmental and food applications. In this paper, we review some of the main advances in the field over the past few years by discussing recent studies from literature.
[...] Read more.
Novel sensitive, rapid and economical biosensors are being developed in a wide range of medical environmental and food applications. In this paper, we review some of the main advances in the field over the past few years by discussing recent studies from literature. A biosensor, which is defined as an analytical device consisting of a biomolecule, a transducer and an output system, can be categorized according to the type of the incorporated biomolecule. The biomolecules can be enzymes, antibodies, ssDNA, organelles, cells etc. The main biosensor categories classified according to the biomolecules are enzymatic biosensors, immunosensors and DNA-based biosensors. These sensors can measure analytes produced or reduced during reactions at lower costs compared to the conventional detection techniques. Numerous types of biosensor studies conducted over the last decade have been explored here to reveal their key applications in medical, environmental and food industries which provide comprehensive perspective to the readers. Overviews of the working principles and applications of the reviewed sensors are also summarized. Full article
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