Novel Methodologies for the Synthesis of Bioactive Molecules

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 416

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy
Interests: organic synthesis; medicinal chemistry; enzyme inhibitors
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Sciences, Università degli Studi di Milano, via Mangiagalli 25, 20133 Milano, Italy
Interests: medicinal chemistry; drug discovery; enzyme inhibitors
Special Issues, Collections and Topics in MDPI journals
Department of Chemistry, University of Turin, Via P. Giuria 7, 10125 Turin, Italy
Interests: tyrosinase inhibitors; synthesis; organometallic chemistry; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of organic synthesis has witnessed significant advancements in recent years, with a particular focus on the development of novel methodologies for the synthesis of biologically relevant molecules. This Special Issue aims to showcase cutting-edge research manuscripts in the design and implementation of innovative strategies that contribute to the efficient and sustainable production of bioactive compounds.

Researchers are exploring several strategies, including but not limited to green chemistry principles, flow chemistry, and unconventional reaction conditions, to revolutionize the synthesis of biologically active molecules. Green chemistry principles emphasize the use of environmentally friendly solvents, the reduction in waste generation, and the minimization of the environmental impact of chemical processes. Flow chemistry, on the other hand, provides a continuous and controlled environment, enhancing reaction efficiency and selectivity.

Contributions to this Special Issue may cover a range of topics, including:

  1. Green synthesis: investigations into the development of eco-friendly methodologies for the synthesis of bioactive molecules, focusing on sustainable practices and minimizing ecological footprints.
  2. Flow chemistry strategies: exploration of continuous flow systems for the synthesis of bioactive compounds, highlighting the advantages of improved reaction control, scalability, and safety.
  3. Unconventional reaction conditions: research on the application of unconventional reaction conditions, such as microwave-assisted synthesis, photochemistry, and electrochemistry, to assist the production of bioactive molecules.
  4. Catalysis and selective transformations: advancements in the use of catalysis and selective transformations to achieve higher yields, reduced by-products, and improved overall efficiency in the synthesis of bioactive compounds.

In addition to these innovative methodologies, we encourage contributors to discuss the potential therapeutic applications of these synthesized bioactive compounds. Hot topics of interest could include their role as enzymatic inhibitors for anticancer, antimicrobial, and antiviral applications or for the treatment of neurological diseases, showcasing the diverse and impactful use of these synthesized bioactive molecules.

We invite researchers and experts in the field to contribute their innovative methodologies and insights to this Special Issue. Submissions will undergo a rigorous peer-review process to ensure the publication of high-quality and impactful research.

We look forward to receiving your contributions to Processes, making this Special Issue a cornerstone for the advancement of novel methodologies in the synthesis of bioactive molecules.

Dr. Andrea Citarella
Dr. Serena Vittorio
Dr. Laura Ielo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic synthesis
  • organic chemistry
  • green synthesis
  • bioactive molecules
  • enzyme inhibitors

Published Papers (1 paper)

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Review

33 pages, 1225 KiB  
Review
Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches
by Michela Galli, Francesco Migliano, Valerio Fasano, Alessandra Silvani, Daniele Passarella and Andrea Citarella
Processes 2024, 12(6), 1242; https://doi.org/10.3390/pr12061242 - 17 Jun 2024
Viewed by 238
Abstract
The global urgency in response to the COVID-19 pandemic has catalyzed extensive research into discovering efficacious antiviral compounds against SARS-CoV-2. Among these, Nirmatrelvir (PF-07321332) has emerged as a promising candidate, exhibiting potent antiviral activity by targeting the main protease of SARS-CoV-2, and has [...] Read more.
The global urgency in response to the COVID-19 pandemic has catalyzed extensive research into discovering efficacious antiviral compounds against SARS-CoV-2. Among these, Nirmatrelvir (PF-07321332) has emerged as a promising candidate, exhibiting potent antiviral activity by targeting the main protease of SARS-CoV-2, and has been marketed in combination with ritonavir as the first oral treatment for COVID-19 with the name of PaxlovidTM. This review outlines the synthetic approaches to Nirmatrelvir, ranging from Pfizer’s original method to newer, more sustainable strategies, such as flow chemistry strategies and multicomponent reactions. Each approach’s novelty and contributions to yield and purification processes are highlighted. Additionally, the synthesis of key fragments comprising Nirmatrelvir and innovative optimization strategies are discussed. Full article
(This article belongs to the Special Issue Novel Methodologies for the Synthesis of Bioactive Molecules)
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