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Polymeric Materials in Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2330

Editor


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Guest Editor
Instituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de las Américas, Santiago, Chile
Interests: polymer materials; polymer nanocomposites; bioactive materials; tissue engineering; wound healing; polymer biomaterials

Special Issue Information

Dear Colleagues,

Tissue engineering is a cutting-edge multidisciplinary field that seeks to restore, maintain, or improve damaged biological tissues and organs. In this context, polymeric materials have emerged as crucial components, serving as cellular scaffolds that mimic the natural extracellular matrix and provide the mechanical and biological support necessary for tissue regeneration.

This Special Issue aims to highlight advances in the development of polymeric materials for tissue engineering applications. We invite submissions addressing the synthesis, characterization, and functionality of novel polymers, biomaterials, and innovative nanocomposites. The focus ranges from the preparation of bioactive and biodegradable scaffolds using cutting-edge processing techniques such as electrospinning, 3D printing, and other novel methods, to the study of material–cell interactions. We also seek to include the incorporation of biologically active compounds and the evaluation of mechanical and biological responses in vitro and in vivo. This Special Issue seeks to contribute to progress in the application of polymers in soft and hard tissue regeneration.

Dr. Daniel Canales
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • polymeric materials
  • biomaterials
  • polymer nanocomposites
  • electrospinning
  • 3D printing
  • regenerative medicine
  • biodegradable scaffolds
  • bioactive compounds
  • surface functionalization

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Published Papers (2 papers)

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Research

27 pages, 7846 KB  
Article
Engineering Porous PET-RAFT Scaffolds with PLGA–Insulin Nanoparticles: Advancing Bone Tissue Regeneration Through Additive Manufacturing
by Fernando E. Rodríguez-Umanzor, Mauricio A. Sarabia-Vallejos, Nicolás F. Acuña-Ruiz, Scarleth A. Romero-De la Fuente, Nicolás A. Cohn-Inostroza, David Ortiz Puerta, Enrique Martínez-Campos, Juan Rodríguez-Hernández, Claudio A. Terraza Inostroza and Carmen M. González-Henríquez
Polymers 2026, 18(10), 1184; https://doi.org/10.3390/polym18101184 - 12 May 2026
Cited by 1 | Viewed by 924
Abstract
Multifunctional scaffolds that combine structural support with the controlled delivery of bioactive agents remain a major challenge in tissue engineering. To extend the use of these devices in biomedicine, 3D printing is presented as an alternative that enables the manufacture of complex devices [...] Read more.
Multifunctional scaffolds that combine structural support with the controlled delivery of bioactive agents remain a major challenge in tissue engineering. To extend the use of these devices in biomedicine, 3D printing is presented as an alternative that enables the manufacture of complex devices tailored to each patient, thereby solving specific problems in a timely and efficient manner. In this study, porous 3D scaffolds were fabricated via digital light processing (DLP) using a PET-RAFT resin composed of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and poly(ethylene glycol) diacrylate (PEGDA575). Sodium chloride (NaCl) was incorporated as a porogen, while insulin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were embedded as osteoinductive agents. The printed constructs exhibited high-resolution, reproducible trabecular-like architectures, as confirmed by micro-computed tomography (micro-CT), with interconnected pores averaging 70.7 ± 24.7 μm and a total porosity of 57.0 ± 6.98%. Thermal and chemical analyses confirmed scaffold stability and controlled degradability. Cytocompatibility assays using MC3T3-E1, C2C12, hGMSCs, and C166-GFP cells showed viability above 80% after 7 days (ISO 10993-5). Insulin-loaded nanoparticles enabled sustained release, characterized by an initial burst followed by gradual release up to 72 h. Dynamic bioreactor culture enhanced cell adhesion and RUNX2 expression, confirming the osteoinductive potential of the hybrid scaffold for advanced BTE applications. This study introduces an innovative PET-RAFT-derived resin that combines structural reinforcement with spatiotemporal regulation of insulin release, offering a potential strategy for enhanced biomaterial tissue engineering and tailored therapeutic interventions. Full article
(This article belongs to the Special Issue Polymeric Materials in Tissue Engineering)
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25 pages, 3439 KB  
Article
Electrospun Multilayer Scaffolds Based on Poly (L-Lactic Acid) and Poly (Acrylonitrile) Reinforced with CaO Nanoparticles for Enhanced Skin Regeneration and Wound Healing
by Eugenio Rivera, Lissette Montoille, Fabián Guajardo, Fabian Álvarez-Carrasco, Sebastián Romero, Mauricio Gómez-Barrena, Esmeralda Lopez, Carlos Loyo, Claudio García-Herrera, Paula A. Zapata, Diana Zárate-Triviño, Juan José Martinez and Daniel A. Canales
Polymers 2026, 18(8), 960; https://doi.org/10.3390/polym18080960 - 15 Apr 2026
Viewed by 971
Abstract
This study reports the development and characterization of hierarchical electrospun scaffolds based on poly (L-lactic acid) (PLA) and polyacrylonitrile (PAN) reinforced with calcium oxide (CaO) nanoparticles (18.5 ± 4.7 nm) for skin regeneration. Six configurations, including two five-layer multilayer systems (PLA/PAN/CaO and PAN/PLA/CaO), [...] Read more.
This study reports the development and characterization of hierarchical electrospun scaffolds based on poly (L-lactic acid) (PLA) and polyacrylonitrile (PAN) reinforced with calcium oxide (CaO) nanoparticles (18.5 ± 4.7 nm) for skin regeneration. Six configurations, including two five-layer multilayer systems (PLA/PAN/CaO and PAN/PLA/CaO), were evaluated to determine how composition and deposition sequence influence physicochemical, mechanical, and biological performance. FT-IR, XRD and DSC confirmed the successful integration of CaO, while thermal analysis evidenced an effect of chain mobility and interfacial interactions within multilayer systems. Cross-sectional SEM revealed the presence of both fibers with continuous interfaces. Nitrogen adsorption showed that CaO significantly increased the specific surface area (e.g., from 4.6 m2/g in neat PLA to 21.65 m2/g in PLA/CaO), with type IV isotherms indicating mesoporosity. Wettability assays demonstrated reduced contact angle in PLA (from 126.3° to 91.8°) and sequence-dependent surface properties in multilayers. Tensile testing confirmed that the multilayer architecture bridged the mechanical gap between compliant PLA and high-strength PAN, yielding intermediate moduli (~10–11 MPa) and balanced toughness. Antibacterial assays against S. aureus and E. coli showed that CaO significantly reduced bacterial viability, with PLA/PAN/CaO achieving the highest inhibition (up to 37.1%). In vitro HaCaT assays and in vivo implantation in BALB/c mice confirmed high cytocompatibility and biocompatibility. These findings demonstrate that multilayer electrospinning of PLA/PAN/CaO enables the design of structurally integrated, bioactive, and mechanically balanced scaffolds for advanced wound healing and dermal repair. Full article
(This article belongs to the Special Issue Polymeric Materials in Tissue Engineering)
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